P68508 (MTA_PAGBO) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 33.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein A Short name=MT-A Short name=MT-I | ||
| Gene names |
| ||
| Organism | Pagothenia borchgrevinki (Bald rockcod) (Trematomus borchgrevinki) | ||
| Taxonomic identifier | 8213 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Nototheniidae › Pagothenia |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster Zinc |
| Gene Ontology (GO) | |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 60 | 60 | Metallothionein A | PRO_0000197302 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 60 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 12 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 18 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 23 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 28 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 32 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 40 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 43 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 47 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 54 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 58 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A By similarity | ||||||
Sequences
References
| [1] | "Metallothioneins in antarctic fish: evidence for independent duplication and gene conversion." Bargelloni L., Scudiero R., Parisi E., Carginale V., Capasso C., Patarnello T. Mol. Biol. Evol. 16:885-897(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ007562 mRNA. Translation: CAA07557.1. |
3D structure databases | |
| ProteinModelPortal | P68508. |
| SMR | P68508. Positions 2-29, 31-60. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG096111. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTA_PAGBO | ||||||||
| Accession | Primary (citable) accession number: P68508 Secondary accession number(s): O13258 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |