Reviewed,
UniProtKB/Swiss-Prot P68506 (MTA_CHIHA)
Last modified
November 24, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein A Short name=MT-A Short name=MT-I | ||
| Gene names |
| ||
| Organism | Chionodraco hamatus (Antarctic teleost icefish) | ||
| Taxonomic identifier | 36188 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chionodraco |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster Zinc |
| Gene Ontology (GO) | |
| Molecular function | zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 60 | 60 | Metallothionein A | PRO_0000197275 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 60 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Cluster B By similarity | ||||||
| Metal binding | 6 | 1 | Cluster B By similarity | ||||||
| Metal binding | 12 | 1 | Cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Cluster B By similarity | ||||||
| Metal binding | 18 | 1 | Cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Cluster B By similarity | ||||||
| Metal binding | 23 | 1 | Cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Cluster B By similarity | ||||||
| Metal binding | 28 | 1 | Cluster B By similarity | ||||||
| Metal binding | 32 | 1 | Cluster A By similarity | ||||||
| Metal binding | 33 | 1 | Cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Cluster A By similarity | ||||||
| Metal binding | 36 | 1 | Cluster A By similarity | ||||||
| Metal binding | 40 | 1 | Cluster A By similarity | ||||||
| Metal binding | 43 | 1 | Cluster A By similarity | ||||||
| Metal binding | 47 | 1 | Cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Cluster A By similarity | ||||||
| Metal binding | 54 | 1 | Cluster A By similarity | ||||||
| Metal binding | 58 | 1 | Cluster A By similarity | ||||||
| Metal binding | 59 | 1 | Cluster A By similarity | ||||||
Sequences
References
| [1] | "Cadmium-induced differential accumulation of metallothionein isoforms in the Antarctic icefish, which exhibits no basal metallothionein protein but high endogenous mRNA levels." Carginale V., Scudiero R., Capasso C., Capasso A., Kille P., di Prisco G., Parisi E. Biochem. J. 332:475-481(1998) [PubMed: 9601077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| Y12580 mRNA. Translation: CAA73159.1. | |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P68506. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTA_CHIHA | ||||||||
| Accession | Primary (citable) accession number: P68506 Secondary accession number(s): O13258 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
