P68505 (MTA_SALAL) Reviewed, UniProtKB/Swiss-Prot
Last modified
March 6, 2013.
Version 32.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein A Short name=MT-A | ||
| Gene names |
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| Organism | Salvelinus alpinus (Arctic char) (Salmo alpinus) | ||
| Taxonomic identifier | 8036 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salvelinus |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Gene Ontology (GO) | |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein A | PRO_0000197312 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 61 | 33 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 12 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 18 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 23 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 28 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 41 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 44 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 48 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 50 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 55 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 60 | 1 | Divalent metal cation; cluster A | ||||||
Experimental info | |||||||||
| Sequence conflict | 14 | 1 | C → S in AAP31403. Ref.3 | ||||||
Sequences
References
| [1] | "Metallothionein cDNA sequences and gene expression in arctic char (Salvelinus alpinus) following metal and PCB exposure." Gerpe M., Kling P., Olsson P.-E. Mar. Environ. Res. 46:551-554(1998) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver. |
| [2] | "Identical coding sequence of metallothionein-A in salmonid fishes inferred from cDNA sequence of arctic char (Salvelinus alpinus)." Egg M., Sturmbauer C., Dallinger R. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver. |
| [3] | "Discovering single nucleotide polymorphisms in the introns of fish genes." McGowan C., Davidson E.A., Davidson W.S. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF013800 mRNA. Translation: AAB66342.1. AF098071 mRNA. Translation: AAC68704.1. AY267819 Genomic DNA. Translation: AAP31403.1. |
3D structure databases | |
| ProteinModelPortal | P68505. |
| SMR | P68505. Positions 2-29, 32-61. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG095741. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTA_SALAL | ||||||||
| Accession | Primary (citable) accession number: P68505 Secondary accession number(s): P09861, Q7ZZW5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |