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P68505 (MTA_SALAL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein A

Short name=MT-A
Gene names
Name:mta
OrganismSalvelinus alpinus (Arctic char) (Salmo alpinus)
Taxonomic identifier8036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalvelinus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein A
PRO_0000197312

Regions

Region1 – 2828Beta
Region29 – 6133Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding121Divalent metal cation; cluster B
Metal binding141Divalent metal cation; cluster B
Metal binding181Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding231Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding281Divalent metal cation; cluster B
Metal binding331Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding411Divalent metal cation; cluster A
Metal binding441Divalent metal cation; cluster A
Metal binding481Divalent metal cation; cluster A
Metal binding501Divalent metal cation; cluster A
Metal binding551Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A
Metal binding601Divalent metal cation; cluster A

Experimental info

Sequence conflict141C → S in AAP31403. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P68505 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 901A8E8084A63EFA

FASTA616,064
        10         20         30         40         50         60 
MDPCECSKTG SCNCGGSCKC SNCACTSCKK ASCCDCCPSG CSKCASGCVC KGKTCDTSCC 


Q 

« Hide

References

[1]"Metallothionein cDNA sequences and gene expression in arctic char (Salvelinus alpinus) following metal and PCB exposure."
Gerpe M., Kling P., Olsson P.-E.
Mar. Environ. Res. 46:551-554(1998)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[2]"Identical coding sequence of metallothionein-A in salmonid fishes inferred from cDNA sequence of arctic char (Salvelinus alpinus)."
Egg M., Sturmbauer C., Dallinger R.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[3]"Discovering single nucleotide polymorphisms in the introns of fish genes."
McGowan C., Davidson E.A., Davidson W.S.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013800 mRNA. Translation: AAB66342.1.
AF098071 mRNA. Translation: AAC68704.1.
AY267819 Genomic DNA. Translation: AAP31403.1.

3D structure databases

ProteinModelPortalP68505.
SMRP68505. Positions 2-29, 32-61.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG095741.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTA_SALAL
AccessionPrimary (citable) accession number: P68505
Secondary accession number(s): P09861, Q7ZZW5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 16, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries