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Protein

Metallothionein A

Gene

mta

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi14Divalent metal cation; cluster B1
Metal bindingi18Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi55Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • cadmium ion binding Source: AgBase
  • zinc ion binding Source: AgBase

GO - Biological processi

  • protein oligomerization Source: AgBase
  • response to cadmium ion Source: AgBase
  • response to copper ion Source: AgBase
  • response to mercury ion Source: AgBase
  • response to zinc ion Source: AgBase

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein A
Short name:
MT-A
Gene namesi
Name:mta
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972951 – 61Metallothionein AAdd BLAST61

Structurei

3D structure databases

ProteinModelPortaliP68503.
SMRiP68503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 61AlphaAdd BLAST33

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG095741.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiView protein in Pfam
PF00131. Metallothio. 1 hit.
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiView protein in PROSITE
PS00203. METALLOTHIONEIN_VRT. 1 hit.

Sequencei

Sequence statusi: Complete.

P68503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPCECSKTG SCNCGGSCKC SNCACTSCKK ASCCDCCPSG CSKCASGCVC
60
KGKTCDTSCC Q
Length:61
Mass (Da):6,064
Last modified:November 23, 2004 - v1
Checksum:i901A8E8084A63EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18103 mRNA. Translation: AAA49565.1.
X59395 mRNA. Translation: CAA42038.1.
M81800 Genomic DNA. Translation: AAA49564.1.
PIRiJC1449.
UniGeneiOmy.11956.

Similar proteinsi

Entry informationi

Entry nameiMTA_ONCMY
AccessioniPrimary (citable) accession number: P68503
Secondary accession number(s): P09861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families