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Protein

Contactin-5

Gene

Cntn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity). Involved in neuronal activity in the auditory system.By similarity1 Publication

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-5
Alternative name(s):
Neural recognition molecule NB-2
Gene namesi
Name:Cntn5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3042287. Cntn5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001471924 – 1071Contactin-5Add BLAST1048
PropeptideiPRO_00000147201072 – 1098Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 172PROSITE-ProRule annotation
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 268PROSITE-ProRule annotation
Disulfide bondi321 ↔ 368PROSITE-ProRule annotation
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi410 ↔ 457PROSITE-ProRule annotation
Glycosylationi448N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi502 ↔ 550PROSITE-ProRule annotation
Glycosylationi539N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi592 ↔ 649PROSITE-ProRule annotation
Glycosylationi778N-linked (GlcNAc...)Sequence analysis1
Glycosylationi815N-linked (GlcNAc...)Sequence analysis1
Glycosylationi930N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1001N-linked (GlcNAc...)Sequence analysis1
Lipidationi1071GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP68500.
PaxDbiP68500.
PRIDEiP68500.

PTM databases

PhosphoSitePlusiP68500.

Expressioni

Tissue specificityi

Expressed in the nervous system. Preferentially expressed in the central auditory pathways.1 Publication

Developmental stagei

Specifically expressed in the postnatal nervous system, reaching a maximum level at 3 weeks postnatal.1 Publication

Gene expression databases

BgeeiENSMUSG00000039488.
CleanExiMM_CNTN5.
ExpressionAtlasiP68500. baseline and differential.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073769.

Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi96 – 102Combined sources7
Beta strandi107 – 109Combined sources3
Beta strandi117 – 120Combined sources4
Beta strandi123 – 128Combined sources6
Beta strandi131 – 136Combined sources6
Helixi143 – 145Combined sources3
Beta strandi149 – 152Combined sources4
Beta strandi155 – 160Combined sources6
Helixi163 – 166Combined sources4
Beta strandi168 – 176Combined sources9
Beta strandi179 – 182Combined sources4
Beta strandi186 – 190Combined sources5
Beta strandi204 – 206Combined sources3
Beta strandi212 – 214Combined sources3
Beta strandi225 – 233Combined sources9
Beta strandi241 – 246Combined sources6
Turni248 – 250Combined sources3
Beta strandi253 – 257Combined sources5
Helixi260 – 262Combined sources3
Beta strandi264 – 272Combined sources9
Turni273 – 275Combined sources3
Beta strandi278 – 280Combined sources3
Beta strandi284 – 288Combined sources5
Beta strandi297 – 303Combined sources7
Beta strandi307 – 312Combined sources6
Beta strandi317 – 320Combined sources4
Beta strandi322 – 327Combined sources6
Beta strandi330 – 335Combined sources6
Beta strandi345 – 347Combined sources3
Turni348 – 351Combined sources4
Beta strandi352 – 355Combined sources4
Helixi360 – 362Combined sources3
Beta strandi364 – 372Combined sources9
Beta strandi375 – 393Combined sources19
Beta strandi398 – 401Combined sources4
Beta strandi406 – 409Combined sources4
Beta strandi411 – 416Combined sources6
Beta strandi419 – 424Combined sources6
Beta strandi431 – 438Combined sources8
Beta strandi441 – 446Combined sources6
Helixi449 – 451Combined sources3
Beta strandi453 – 461Combined sources9
Beta strandi464 – 475Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4IX-ray2.60A96-477[»]
ProteinModelPortaliP68500.
SMRiP68500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 189Ig-like C2-type 1Add BLAST92
Domaini195 – 281Ig-like C2-type 2Add BLAST87
Domaini299 – 384Ig-like C2-type 3Add BLAST86
Domaini389 – 473Ig-like C2-type 4Add BLAST85
Domaini479 – 568Ig-like C2-type 5Add BLAST90
Domaini570 – 659Ig-like C2-type 6Add BLAST90
Domaini672 – 770Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini775 – 872Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini877 – 971Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini976 – 1066Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP68500.
KOiK06763.
OMAiMIHNVNQ.
OrthoDBiEOG091G00X7.
PhylomeDBiP68500.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCWRLILF LSVTRWLSDY SEALSGLSTS YAALLRIKKS STSPFGSKSR
60 70 80 90 100
PRFSSPSLGT ISVSPPSWRG AAQQYHSPGN LYHSSDAFRQ DESVDYGPVF
110 120 130 140 150
VQEPDDVIFP TDSDEKKVAL NCEVRGNPSP SYRWLRNGTE IALESDYRYS
160 170 180 190 200
LIDGTFIISN PSELRDSGLY QCLATNSFGS ILSREATLQF AYLGNFSGRT
210 220 230 240 250
RSAVSVREGQ GVVLMCSPPP HSPEIIYSWV FNEFPSFVAE DSRRFISQET
260 270 280 290 300
GNLYISKVQT SDVGSYICLV KNAVTNARVL SPPTPLTLRN DGVMGEYEPK
310 320 330 340 350
IEVHFPFTVT AAKGTTVKME CFALGNPVPT ITWMKVNGYI PSKSRLRKSQ
360 370 380 390 400
AVLEIPNLQL DDAGIYECTA ENSRGKNSFR GQLQIFTYPH WVQKLNDTQL
410 420 430 440 450
DSGSPLQWEC KATGKPRPTY RWLKNGAPLL PQSRVDTVNG ILAIQSVNQS
460 470 480 490 500
DAGMYQCLAE NKYGAIYASA ELKILASPPS FELNQVKKSI IVTKDRGVLI
510 520 530 540 550
ECEPQGSPKP AISWRKGDKA VRANKRIAIL PDGSLRILNA SKADEGKYIC
560 570 580 590 600
QGVNIFGSAE IIASLSVKEP TRIELTPKRT ELTVGESIVL NCKAIHDASL
610 620 630 640 650
DVTFYWTLKG QPIDFEKEGG HFENIRAQAS SADLMIRNIL LMHAGRYGCR
660 670 680 690 700
VQTTADSVSD EAELLVRGPP GPPGVVIVEE ITESTATLSW SPATDNHSPI
710 720 730 740 750
SSYNLQARSP FSLGWQTVKT VPEVITGDME SAMAVDLNPW VEYEFRVVAT
760 770 780 790 800
NPIGTGDPSI PSRMIRTNEA VPKTAPSNVS GRSGRRHELV IAWEPVSEEF
810 820 830 840 850
QNGEGFGYIV AFRPNGTRGW KEKMVTSSEA SKFIYRDESV PPLTPFEVKV
860 870 880 890 900
GVYNNKGDGP FSQIVVICSA EGEPTAAPTD VTATSVSVSE IFVVWKHVKE
910 920 930 940 950
SLGRPQGFEI SYWKDTEPED SVETVRTRGN ESFVMLTGLE GNTLYHLTVR
960 970 980 990 1000
AYNGAGYGPP SREASTTTKR HPPREPPGNL RWEQQGSQVS LGWEPVRPLA
1010 1020 1030 1040 1050
NESEVMGYKV FYRQEGHSEG QVIETQKPQA VVPLPEAGVY IIEVRAYSEG
1060 1070 1080 1090
GDGTASSQIR VPSYSGGKIT SAQSTLHSLS KWSSVTLLLA LMLPSSSW
Length:1,098
Mass (Da):120,746
Last modified:July 27, 2011 - v2
Checksum:i201929C9C7C5C3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100491 Genomic DNA. No translation available.
AC102350 Genomic DNA. No translation available.
AC107635 Genomic DNA. No translation available.
AC113470 Genomic DNA. No translation available.
AC117684 Genomic DNA. No translation available.
AC118029 Genomic DNA. No translation available.
AC153417 Genomic DNA. No translation available.
AC154645 Genomic DNA. No translation available.
AC154651 Genomic DNA. No translation available.
CT033779 Genomic DNA. No translation available.
CCDSiCCDS52722.1.
RefSeqiNP_001164258.1. NM_001170787.1.
XP_006509935.1. XM_006509872.3.
UniGeneiMm.187021.
Mm.490683.

Genome annotation databases

EnsembliENSMUST00000074133; ENSMUSP00000073769; ENSMUSG00000039488.
ENSMUST00000160216; ENSMUSP00000124327; ENSMUSG00000039488.
GeneIDi244682.
KEGGimmu:244682.
UCSCiuc012goa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100491 Genomic DNA. No translation available.
AC102350 Genomic DNA. No translation available.
AC107635 Genomic DNA. No translation available.
AC113470 Genomic DNA. No translation available.
AC117684 Genomic DNA. No translation available.
AC118029 Genomic DNA. No translation available.
AC153417 Genomic DNA. No translation available.
AC154645 Genomic DNA. No translation available.
AC154651 Genomic DNA. No translation available.
CT033779 Genomic DNA. No translation available.
CCDSiCCDS52722.1.
RefSeqiNP_001164258.1. NM_001170787.1.
XP_006509935.1. XM_006509872.3.
UniGeneiMm.187021.
Mm.490683.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4IX-ray2.60A96-477[»]
ProteinModelPortaliP68500.
SMRiP68500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073769.

PTM databases

PhosphoSitePlusiP68500.

Proteomic databases

MaxQBiP68500.
PaxDbiP68500.
PRIDEiP68500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074133; ENSMUSP00000073769; ENSMUSG00000039488.
ENSMUST00000160216; ENSMUSP00000124327; ENSMUSG00000039488.
GeneIDi244682.
KEGGimmu:244682.
UCSCiuc012goa.1. mouse.

Organism-specific databases

CTDi53942.
MGIiMGI:3042287. Cntn5.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP68500.
KOiK06763.
OMAiMIHNVNQ.
OrthoDBiEOG091G00X7.
PhylomeDBiP68500.
TreeFamiTF351103.

Miscellaneous databases

PROiP68500.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039488.
CleanExiMM_CNTN5.
ExpressionAtlasiP68500. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN5_MOUSE
AccessioniPrimary (citable) accession number: P68500
Secondary accession number(s): E0CYC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.