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Protein

Metallothionein

Gene
N/A
Organism
Phasianus colchicus colchicus (Black-necked pheasant)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi8Divalent metal cation; cluster B1
Metal bindingi11Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi16Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster A1
Metal bindingi21Divalent metal cation; cluster A1
Metal bindingi23Divalent metal cation; cluster A1
Metal bindingi24Divalent metal cation; cluster A1
Metal bindingi28Divalent metal cation; cluster A1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi45Divalent metal cation; cluster A1
Metal bindingi47Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
OrganismiPhasianus colchicus colchicus (Black-necked pheasant)
Taxonomic identifieri9057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaePhasianus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000197266‹1 – 49MetallothioneinAdd BLAST›49

Structurei

3D structure databases

ProteinModelPortaliP68499.
SMRiP68499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 16BetaAdd BLAST16
Regioni17 – 49AlphaAdd BLAST33

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiView protein in Pfam
PF00131. Metallothio. 1 hit.
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Fragment.

P68499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CAKGCVCKEP ASSKCSCCH
Length:49
Mass (Da):5,063
Last modified:November 23, 2004 - v1
Checksum:iECCA838766753612
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62510 mRNA. Translation: CAA44369.1.

Similar proteinsi

Entry informationi

Entry nameiMT_PHACO
AccessioniPrimary (citable) accession number: P68499
Secondary accession number(s): P09576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families