Reviewed,
UniProtKB/Swiss-Prot P68497 (MT_CHICK)
Last modified
November 24, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein Short name=MT |
| Organism | Gallus gallus (Chicken) |
| Taxonomic identifier | 9031 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 63 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster Zinc |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Molecular function | zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 63 | 63 | Metallothionein | PRO_0000197260 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 63 | 33 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Cluster B | ||||||
| Metal binding | 8 | 1 | Cluster B | ||||||
| Metal binding | 14 | 1 | Cluster B | ||||||
| Metal binding | 16 | 1 | Cluster B | ||||||
| Metal binding | 20 | 1 | Cluster B | ||||||
| Metal binding | 22 | 1 | Cluster B | ||||||
| Metal binding | 25 | 1 | Cluster B | ||||||
| Metal binding | 27 | 1 | Cluster B | ||||||
| Metal binding | 30 | 1 | Cluster B | ||||||
| Metal binding | 34 | 1 | Cluster A | ||||||
| Metal binding | 35 | 1 | Cluster A | ||||||
| Metal binding | 37 | 1 | Cluster A | ||||||
| Metal binding | 38 | 1 | Cluster A | ||||||
| Metal binding | 42 | 1 | Cluster A | ||||||
| Metal binding | 45 | 1 | Cluster A | ||||||
| Metal binding | 49 | 1 | Cluster A | ||||||
| Metal binding | 51 | 1 | Cluster A | ||||||
| Metal binding | 59 | 1 | Cluster A | ||||||
| Metal binding | 61 | 1 | Cluster A | ||||||
| Metal binding | 62 | 1 | Cluster A | ||||||
Sequences
References
| [1] | "Amino acid sequence and comparative antigenicity of chicken metallothionein." McCormick C.C., Fullmer C.S., Garvey J.S. Proc. Natl. Acad. Sci. U.S.A. 85:309-313(1988) [PubMed: 2448773] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver. |
| [2] | "Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA." Wei D., Andrews G.K. Nucleic Acids Res. 16:537-553(1988) [PubMed: 3340548] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: White leghorn. |
| [3] | "Structure and expression of chicken metallothionein." Fernando L.P., Wei D., Andrews G.K. J. Nutr. 119:309-318(1989) [PubMed: 2645390] [Abstract] Cited for: PROTEIN SEQUENCE. |
| [4] | "Cloning and expression of an avian metallothionein-encoding gene." Fernando L.P., Andrews G.K. Gene 81:177-183(1989) [PubMed: 2806910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| X06749 mRNA. Translation: CAA29924.1. X13545 Genomic DNA. No translation available. | |
| IPI | IPI00588333. |
| PIR | A34958. |
| RefSeq | NP_990606.1. |
| UniGene | Gga.4210 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 396212. |
| KEGG | gga:396212. |
Organism-specific databases | |
| CTD | 396212. |
Phylogenomic databases | |
| HOVERGEN | P68497. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT_CHICK | ||||||||
| Accession | Primary (citable) accession number: P68497 Secondary accession number(s): P09576 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
