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Protein

Protein K7

Gene

K7R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
ORF Names:K7R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Protein K7PRO_0000099608Add
BLAST

Interactioni

Subunit structurei

Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX3XO005716EBI-8022707,EBI-353779From a different organism.
IRAK2O431872EBI-8022707,EBI-447733From a different organism.

Protein-protein interaction databases

IntActiP68467. 3 interactions.
MINTiMINT-6947415.

Structurei

3D structure databases

ProteinModelPortaliP68467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae K7 protein family.Curated

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.

Sequencei

Sequence statusi: Complete.

P68467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC
60 70 80 90 100
GRLYKELMKF DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA
110 120 130 140
TIGICAKITE HWGYKKISES RFQSLGNITD LMTDDNINIL ILFLEKKLN
Length:149
Mass (Da):17,468
Last modified:November 23, 2004 - v1
Checksum:iB3E972A93DF97DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48013.1.
PIRiJS0217. WMVZK7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48013.1.
PIRiJS0217. WMVZK7.

3D structure databases

ProteinModelPortaliP68467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP68467. 3 interactions.
MINTiMINT-6947415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Appendix to 'The complete DNA sequence of vaccinia virus'."
    Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
    Virology 179:517-563(1990)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiK7_VACCC
AccessioniPrimary (citable) accession number: P68467
Secondary accession number(s): P18382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.