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Protein

Protein K7

Gene

VACWR039

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
Ordered Locus Names:VACWR039
ORF Names:K7R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Protein K7PRO_0000099609Add
BLAST

Interactioni

Subunit structurei

Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation.2 Publications

Protein-protein interaction databases

DIPiDIP-48288N.
IntActiP68466. 28 interactions.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93Combined sources
Turni13 – 164Combined sources
Helixi23 – 253Combined sources
Helixi26 – 4217Combined sources
Beta strandi47 – 504Combined sources
Helixi52 – 587Combined sources
Helixi60 – 689Combined sources
Helixi70 – 8011Combined sources
Helixi89 – 913Combined sources
Helixi95 – 11420Combined sources
Helixi119 – 1213Combined sources
Helixi128 – 1314Combined sources
Helixi134 – 14815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K36NMR-A1-149[»]
3JRVX-ray1.60A/B1-149[»]
ProteinModelPortaliP68466.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68466.

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae K7 protein family.Curated

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.

Sequencei

Sequence statusi: Complete.

P68466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC
60 70 80 90 100
GRLYKELMKF DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA
110 120 130 140
TIGICAKITE HWGYKKISES RFQSLGNITD LMTDDNINIL ILFLEKKLN
Length:149
Mass (Da):17,468
Last modified:November 23, 2004 - v1
Checksum:iB3E972A93DF97DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00382 Genomic DNA. Translation: BAA00293.1.
AY243312 Genomic DNA. Translation: AAO89318.1.
PIRiJS0217. WMVZK7.
RefSeqiYP_232921.1. NC_006998.1.

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00382 Genomic DNA. Translation: BAA00293.1.
AY243312 Genomic DNA. Translation: AAO89318.1.
PIRiJS0217. WMVZK7.
RefSeqiYP_232921.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K36NMR-A1-149[»]
3JRVX-ray1.60A/B1-149[»]
ProteinModelPortaliP68466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48288N.
IntActiP68466. 28 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Miscellaneous databases

EvolutionaryTraceiP68466.

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Non-essential genes in the vaccinia virus HindIII K fragment: a gene related to serine protease inhibitors and a gene related to the 37K vaccinia virus major envelope antigen."
    Boursnell M.E.G., Foulds I.J., Campbell J.I., Binns M.M.
    J. Gen. Virol. 69:2995-3003(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb."
    Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation."
    Schroder M., Baran M., Bowie A.G.
    EMBO J. 27:2147-2157(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN TRAF6 AND IRAK2.
  4. "Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7."
    Oda S., Schroder M., Khan A.R.
    Structure 17:1528-1537(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN DDX3X, X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiK7_VACCW
AccessioniPrimary (citable) accession number: P68466
Secondary accession number(s): P18382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.