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Protein

Protein K7

Gene

VACWR039

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
Ordered Locus Names:VACWR039
ORF Names:K7R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996091 – 149Protein K7Add BLAST149

Interactioni

Subunit structurei

Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation.2 Publications

Protein-protein interaction databases

DIPiDIP-48288N.
IntActiP68466. 28 interactors.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Turni13 – 16Combined sources4
Helixi23 – 25Combined sources3
Helixi26 – 42Combined sources17
Beta strandi47 – 50Combined sources4
Helixi52 – 58Combined sources7
Helixi60 – 68Combined sources9
Helixi70 – 80Combined sources11
Helixi89 – 91Combined sources3
Helixi95 – 114Combined sources20
Helixi119 – 121Combined sources3
Helixi128 – 131Combined sources4
Helixi134 – 148Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K36NMR-A1-149[»]
3JRVX-ray1.60A/B1-149[»]
ProteinModelPortaliP68466.
SMRiP68466.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68466.

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae K7 protein family.Curated

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.

Sequencei

Sequence statusi: Complete.

P68466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC
60 70 80 90 100
GRLYKELMKF DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA
110 120 130 140
TIGICAKITE HWGYKKISES RFQSLGNITD LMTDDNINIL ILFLEKKLN
Length:149
Mass (Da):17,468
Last modified:November 23, 2004 - v1
Checksum:iB3E972A93DF97DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00382 Genomic DNA. Translation: BAA00293.1.
AY243312 Genomic DNA. Translation: AAO89318.1.
PIRiJS0217. WMVZK7.
RefSeqiYP_232921.1. NC_006998.1.

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00382 Genomic DNA. Translation: BAA00293.1.
AY243312 Genomic DNA. Translation: AAO89318.1.
PIRiJS0217. WMVZK7.
RefSeqiYP_232921.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K36NMR-A1-149[»]
3JRVX-ray1.60A/B1-149[»]
ProteinModelPortaliP68466.
SMRiP68466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48288N.
IntActiP68466. 28 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707496.
KEGGivg:3707496.

Miscellaneous databases

EvolutionaryTraceiP68466.

Family and domain databases

InterProiIPR009174. Orthopox_K7.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003764. VAC_K7R. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiK7_VACCW
AccessioniPrimary (citable) accession number: P68466
Secondary accession number(s): P18382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.