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Protein

Telomere-binding protein I6

Gene

VACWR075

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the hairpin form of the viral telomeric sequence. Might direct genome encapsidation into the virus particle.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere-binding protein I6
Gene namesi
Ordered Locus Names:VACWR075
ORF Names:I6L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Virion

  • Note: Present in the virus core.

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14 – 18KPTKK → APTAA: Reduced plaque size at 32 degrees Celsius. 1 Publication5
Mutagenesisi56 – 60EDVLK → AAVLA: Reduced plaque size at 32 degrees Celsius. 1 Publication5
Mutagenesisi103 – 105DDD → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication3
Mutagenesisi145 – 147EKE → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication3
Mutagenesisi196 – 198KER → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication3
Mutagenesisi305 – 306KR → AA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication2
Mutagenesisi359 – 361KKK → AAA: 100-fold reduction in viral yield at 40 degrees Celsius. Failure in genome encapsidation at 40 degrees Celsius. 1 Publication3
Mutagenesisi364 – 365KK → AA: Reduced plaque size at 32 degrees Celsius. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995791 – 382Telomere-binding protein I6Add BLAST382

Structurei

3D structure databases

SMRiP68462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae I6 family.Curated

Phylogenomic databases

OrthoDBiVOG090000CG.

Family and domain databases

InterProiView protein in InterPro
IPR007674. Poxvirus_36kDa_major_membrane.
IPR022219. Poxvirus_I6_C.
PfamiView protein in Pfam
PF12562. DUF3746. 1 hit.
PF04595. Pox_I6. 1 hit.

Sequencei

Sequence statusi: Complete.

P68462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFVKQVAS KSLKPTKKLS PSDEVISLNE CIISFNLDNF YYCNDGLFTK
60 70 80 90 100
PINTPEDVLK SLLIMESFAY EKMIIKGLIK ILISRAYIND IYFTPFGWLT
110 120 130 140 150
GVDDDPETHV VIKIIFNSSL ISIKSQVIEY LKPYNVNNLS VLTTEKELSI
160 170 180 190 200
NTFNVPDSIP MSIISFFPFD TDFILVILFF GVYNDSYCGI SYISPKERLP
210 220 230 240 250
YIIEILKPLV SEINMLSDEI GRTSSIRIFN STSVKKFPTN TLTSICEIVY
260 270 280 290 300
SFDESSFPTP KTFTPLNASP YIPKKIVSLL DLPSNVEIKA ISRGGVDFIT
310 320 330 340 350
HINNKRLNTI LVIAKDNFLK NSTFSGTFIK ENIIWKGIYT YRIIKSSFPV
360 370 380
PTIKSVTNKK KICKKHCFVN SQYTTRTLSH IL
Length:382
Mass (Da):43,454
Last modified:November 23, 2004 - v1
Checksum:i4D0F72666DEE1307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03399 Genomic DNA. Translation: AAB59808.1.
AY243312 Genomic DNA. Translation: AAO89354.1.
PIRiF29889. WZVZI6.
RefSeqiYP_232957.1. NC_006998.1.

Genome annotation databases

GeneIDi3707608.
KEGGivg:3707608.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiI6_VACCW
AccessioniPrimary (citable) accession number: P68462
Secondary accession number(s): P12925, Q76ZU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 15, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families