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Protein

Protein G3

Gene

VACWR079

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation) (Probable).Curated

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi1.G.11.1.1. the poxvirus cell entry protein complex (pep-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein G3
Gene namesi
Ordered Locus Names:VACWR079
ORF Names:G3L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Signal-anchorSequence analysisAdd BLAST21
Topological domaini22 – 111Virion surfaceSequence analysisAdd BLAST90

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995281 – 111Protein G3Add BLAST111

Interactioni

Subunit structurei

Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex. Interacts with L5.2 Publications

Structurei

3D structure databases

SMRiP68458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae G3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001E8.

Family and domain databases

InterProiView protein in InterPro
IPR010367. Poxvirus_G3.
PfamiView protein in Pfam
PF06129. Chordopox_G3. 1 hit.

Sequencei

Sequence statusi: Complete.

P68458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLYLILF LLFVCISYYF TYYPTNKLQA AVMETDRENA IIRQRNDEIP
60 70 80 90 100
TRTLDTAIFT DASTVASAQI HLYYNSNIGK IIMSLNGKKH TFNLYDDNDI
110
RTLLPILLLS K
Length:111
Mass (Da):12,803
Last modified:November 23, 2004 - v1
Checksum:i9BCD24ABADC2B07D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03399 Genomic DNA. Translation: AAB59812.1.
AY243312 Genomic DNA. Translation: AAO89358.1.
RefSeqiYP_232961.1. NC_006998.1.

Genome annotation databases

GeneIDi3707535.
KEGGivg:3707535.

Similar proteinsi

Entry informationi

Entry nameiG3_VACCW
AccessioniPrimary (citable) accession number: P68458
Secondary accession number(s): P21024, Q76ZU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families