VACWR063

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein E7
Gene namesⁱ	Ordered Locus Names:VACWR063 ORF Names:E7R
Organismⁱ	Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifierⁱ	10254 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus
Virus hostⁱ	Bos taurus (Bovine) [TaxID: 9913]
Proteomesⁱ	UP000000344 Componentⁱ: Genome

Subcellular locationⁱ

Host cytoplasm
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.4
  "Identification and analysis of three myristylated vaccinia virus late proteins."
  Martin K.H., Grosenbach D.W., Franke C.A., Hruby D.E.
  J. Virol. 71:5218-5226(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-2.

GO - Cellular componentⁱ

host cell cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	2	G → A: Complete loss of myristoylation. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed; by host
ChainⁱPRO_0000099459	2 – 166	Protein E7Add BLAST		165

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine; by host1 Publication		1

Post-translational modificationⁱ

Myristoylated.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate

PTM databases

iPTMnetⁱ	P68446.

iPTMnetⁱ

P68446.

Interactionⁱ

Protein-protein interaction databases

ELMⁱ	P68446.
IntActⁱ	P68446. 1 interactor.
Molecular INTeraction database More...MINTⁱ	P68446.

Structureⁱ

3D structure databases

SMRⁱ	P68446.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the chordopoxvirinae E7 family.Curated

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000XK.

OrthoDBⁱ

VOG090000XK.

Family and domain databases

InterProⁱ	View protein in InterPro IPR035345. E7R.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17467. E7R. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD027155. PD027155. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P68446-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTAATIQTP TKLMNKENAE MILEKIVDHI VMYISDESSD SENNPEYIDF 
        60         70         80         90        100
RNRYEDYRSL IIKSDHEFVK LCKNHAEKSS PETQQMIIKH IYEQYLIPVS 
       110        120        130        140        150
EVLLKPIMSM GDIITYNGCK DNEWMLEQLS TLNFNNLRTW NSCSIGNVTR 
       160 
LFYTFFSYLM KDKLNI

Length:166

Mass (Da):19,512

Last modified:January 23, 2007 - v3

Checksum:ⁱ0E527693710FD087

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36339 Genomic DNA. Translation: AAB59827.1. M13213 Genomic DNA. Translation: AAA98421.1. AY243312 Genomic DNA. Translation: AAO89342.1.
NCBI Reference Sequences More...RefSeqⁱ	YP_232945.1. NC_006998.1.

Genome annotation databases

GeneIDⁱ	3707596.
KEGGⁱ	vg:3707596.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P68446	P68447 Q76RE3 Q1M1Q6 Q0GP24 V5R0E4 B9U1D5 Q77TM4 A0A2I2MDS9	Vaccinia virus (strain Copenhagen) (VACV) Vaccinia virus (strain Ankara) (VACV) Vaccinia virus Horsepox virus (HSPV) Vaccinia virus WAU86/88-1 Vaccinia virus GLV-1h68 Vaccinia virus (strain Tian Tan) (VACV) Suid alphaherpesvirus 1	166	UniRef100_P68447	Cluster: Protein E7	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P68446	P68447 Q76RE3 Q1M1Q6 Q0GP24 V5R0E4 B9U1D5 Q77TM4 A0A2I2MDS9 Q5IXX0 Q8V525 +40	Vaccinia virus (strain Copenhagen) (VACV) Vaccinia virus (strain Ankara) (VACV) Vaccinia virus Horsepox virus (HSPV) Vaccinia virus WAU86/88-1 Vaccinia virus GLV-1h68 Vaccinia virus (strain Tian Tan) (VACV) Suid alphaherpesvirus 1 Monkeypox virus Monkeypox virus (strain Zaire-96-I-16) (MPX) And more	166	UniRef90_P68447	Cluster: Protein E7	51

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P68446	P68447 Q76RE3 Q1M1Q6 Q0GP24 V5R0E4 B9U1D5 Q77TM4 A0A2I2MDS9 V9NPT1 U5TJZ4 +43	Vaccinia virus (strain Copenhagen) (VACV) Vaccinia virus (strain Ankara) (VACV) Vaccinia virus Horsepox virus (HSPV) Vaccinia virus WAU86/88-1 Vaccinia virus GLV-1h68 Vaccinia virus (strain Tian Tan) (VACV) Suid alphaherpesvirus 1 Monkeypox virus Cowpox virus (CPV) And more	166	UniRef50_P68447	Cluster: Protein E7	54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36339 Genomic DNA. Translation: AAB59827.1. M13213 Genomic DNA. Translation: AAA98421.1. AY243312 Genomic DNA. Translation: AAO89342.1.
NCBI Reference Sequences More...RefSeqⁱ	YP_232945.1. NC_006998.1.

3D structure databases

SMRⁱ	P68446.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	P68446.
IntActⁱ	P68446. 1 interactor.
Molecular INTeraction database More...MINTⁱ	P68446.

PTM databases

iPTMnetⁱ	P68446.

iPTMnetⁱ

P68446.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3707596.
KEGGⁱ	vg:3707596.

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000XK.

OrthoDBⁱ

VOG090000XK.

Family and domain databases

InterProⁱ	View protein in InterPro IPR035345. E7R.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17467. E7R. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD027155. PD027155. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E7_VACCW
Accessionⁱ	P68446Primary (citable) accession number: P68446 Secondary accession number(s): P21048, Q76ZV8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	January 23, 2007
	Last modified:	February 28, 2018
	This is version 46 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P68446 (E7_VACCW)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein E7

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ