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P68390

- IOVO_MELGA

UniProt

P68390 - IOVO_MELGA

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Protein
Ovomucoid
Gene
N/A
Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 892Reactive bond 2 for trypsin
Sitei147 – 1482Reactive bond 3 for chymotrypsin, elastase, proteases A and B, and subtilisin

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: AgBase

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovomucoid
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
ProteomesiUP000001645: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2116. Mel g 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Ovomucoid
PRO_0000073142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 43
Disulfide bondi22 ↔ 40
Disulfide bondi30 ↔ 61
Disulfide bondi69 ↔ 108
Disulfide bondi86 ↔ 105
Disulfide bondi94 ↔ 126
Disulfide bondi137 ↔ 167
Disulfide bondi145 ↔ 164
Disulfide bondi153 ↔ 185
Glycosylationi174 – 1741N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP68390.

Interactioni

Protein-protein interaction databases

MINTiMINT-1505027.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 713
Beta strandi74 – 763
Beta strandi82 – 843
Beta strandi93 – 953
Beta strandi100 – 1034
Helixi104 – 11411
Beta strandi120 – 1245
Beta strandi132 – 1343
Helixi137 – 1393
Beta strandi143 – 1464
Beta strandi152 – 1543
Beta strandi159 – 1624
Helixi163 – 17210
Turni173 – 1753
Beta strandi179 – 1835

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CHOX-ray1.80I130-185[»]
1CSOX-ray1.90I135-185[»]
1CT0X-ray1.80I135-185[»]
1CT2X-ray1.65I135-185[»]
1CT4X-ray1.60I135-185[»]
1DS2X-ray1.70I135-185[»]
1DS3X-ray1.65I135-185[»]
1HJAX-ray2.30I135-185[»]
1OMTNMR-A130-185[»]
1OMUNMR-A130-185[»]
1PPFX-ray1.80I130-185[»]
1R0RX-ray1.10I135-185[»]
1SGDX-ray1.80I135-185[»]
1SGEX-ray1.80I135-185[»]
1SGNX-ray1.80I135-185[»]
1SGPX-ray1.40I135-185[»]
1SGQX-ray1.90I135-185[»]
1SGRX-ray1.80I135-185[»]
1SGYX-ray1.80I135-185[»]
1TURNMR-A130-185[»]
1TUSNMR-A130-185[»]
1YU6X-ray1.55C/D1-185[»]
1Z7KX-ray1.90B65-126[»]
C12-15[»]
2GKRX-ray1.16I135-185[»]
2GKTX-ray1.23I135-185[»]
2GKVX-ray1.70A/B135-185[»]
2SGDX-ray1.80I135-185[»]
2SGEX-ray1.80I135-185[»]
2SGFX-ray1.75I135-185[»]
2SGPX-ray1.80I135-185[»]
2SGQX-ray1.80I135-185[»]
3SGBX-ray1.80I130-185[»]
3SGQX-ray1.80I135-185[»]
ProteinModelPortaliP68390.
SMRiP68390. Positions 1-61, 65-126, 130-185.

Miscellaneous databases

EvolutionaryTraceiP68390.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6363Kazal-like 1
Add
BLAST
Domaini64 – 12865Kazal-like 2
Add
BLAST
Domaini131 – 18555Kazal-like 3
Add
BLAST

Domaini

Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.4 Publications

Sequence similaritiesi

Contains 3 Kazal-like domains.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG006172.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view]
PfamiPF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PRINTSiPR00290. KAZALINHBTR.
SMARTiSM00280. KAZAL. 3 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68390-1 [UniParc]FASTAAdd to Basket

« Hide

VEVDCSRFPN TTNEEGKDVL VCTEDLRPIC GTDGVTHSEC LLCAYNIEYG    50
TNISKEHDGE CREAVPMDCS RYPNTTSEEG KVMILCNKAL NPVCGTDGVT 100
YDNECVLCAH NLEQGTSVGK KHDGECRKEL AAVSVDCSEY PKPACTLEYR 150
PLCGSDNKTY GNKCNFCNAV VESNGTLTLS HFGKC 185
Length:185
Mass (Da):20,156
Last modified:July 21, 1986 - v1
Checksum:i24BB83F5A66A1A76
GO

Sequence databases

PIRiA01238. TITKM.

Cross-referencesi

Sequence databases

PIRi A01238. TITKM.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CHO X-ray 1.80 I 130-185 [» ]
1CSO X-ray 1.90 I 135-185 [» ]
1CT0 X-ray 1.80 I 135-185 [» ]
1CT2 X-ray 1.65 I 135-185 [» ]
1CT4 X-ray 1.60 I 135-185 [» ]
1DS2 X-ray 1.70 I 135-185 [» ]
1DS3 X-ray 1.65 I 135-185 [» ]
1HJA X-ray 2.30 I 135-185 [» ]
1OMT NMR - A 130-185 [» ]
1OMU NMR - A 130-185 [» ]
1PPF X-ray 1.80 I 130-185 [» ]
1R0R X-ray 1.10 I 135-185 [» ]
1SGD X-ray 1.80 I 135-185 [» ]
1SGE X-ray 1.80 I 135-185 [» ]
1SGN X-ray 1.80 I 135-185 [» ]
1SGP X-ray 1.40 I 135-185 [» ]
1SGQ X-ray 1.90 I 135-185 [» ]
1SGR X-ray 1.80 I 135-185 [» ]
1SGY X-ray 1.80 I 135-185 [» ]
1TUR NMR - A 130-185 [» ]
1TUS NMR - A 130-185 [» ]
1YU6 X-ray 1.55 C/D 1-185 [» ]
1Z7K X-ray 1.90 B 65-126 [» ]
C 12-15 [» ]
2GKR X-ray 1.16 I 135-185 [» ]
2GKT X-ray 1.23 I 135-185 [» ]
2GKV X-ray 1.70 A/B 135-185 [» ]
2SGD X-ray 1.80 I 135-185 [» ]
2SGE X-ray 1.80 I 135-185 [» ]
2SGF X-ray 1.75 I 135-185 [» ]
2SGP X-ray 1.80 I 135-185 [» ]
2SGQ X-ray 1.80 I 135-185 [» ]
3SGB X-ray 1.80 I 130-185 [» ]
3SGQ X-ray 1.80 I 135-185 [» ]
ProteinModelPortali P68390.
SMRi P68390. Positions 1-61, 65-126, 130-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1505027.

Protein family/group databases

Allergomei 2116. Mel g 1.
MEROPSi I01.001.

Proteomic databases

PRIDEi P68390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006172.

Miscellaneous databases

EvolutionaryTracei P68390.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR001239. Prot_inh_Kazal-m.
[Graphical view ]
Pfami PF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
PRINTSi PR00290. KAZALINHBTR.
SMARTi SM00280. KAZAL. 3 hits.
[Graphical view ]
PROSITEi PS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of avian ovomucoids."
    Kato I., Kohr W.J., Laskowski M. Jr.
    (In) Magnusson S., Ottesen M., Foltmann B., Dano K., Neurath H. (eds.); Regulatory proteolytic enzymes and their inhibitors, pp.197-206, Pergamon Press, New York (1978)
    Cited for: PROTEIN SEQUENCE.
  2. "Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey."
    Fujinaga M., Read R.J., Sielecki A., Ardelt W., Laskowski M. Jr., James M.N.G.
    Proc. Natl. Acad. Sci. U.S.A. 79:4868-4872(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF THIRD DOMAIN.
  3. Ding J., Qasim M.A., Laskowski M. Jr., James M.N.G.
    Submitted (JUL-1997) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THIRD DOMAIN.
  4. "Conformation of the third domain of turkey ovomucoid in solution. Structural analysis by two-dimensional Overhauser nuclear effect spectroscopy."
    Andrianov A.M.
    Mol. Biol. (Mosk.) 25:1215-1225(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF THIRD DOMAIN.
  5. "Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data."
    Krezel A.M., Darba P., Robertson A.D., Fejzo J., Macura S., Markley J.L.
    J. Mol. Biol. 242:203-214(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF THIRD DOMAIN.

Entry informationi

Entry nameiIOVO_MELGA
AccessioniPrimary (citable) accession number: P68390
Secondary accession number(s): P01004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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