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P68390

- IOVO_MELGA

UniProt

P68390 - IOVO_MELGA

Protein

Ovomucoid

Gene
N/A
Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei88 – 892Reactive bond 2 for trypsin
    Sitei147 – 1482Reactive bond 3 for chymotrypsin, elastase, proteases A and B, and subtilisin

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: AgBase

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: GOC

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI01.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovomucoid
    OrganismiMeleagris gallopavo (Common turkey)
    Taxonomic identifieri9103 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
    ProteomesiUP000001645: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2116. Mel g 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185OvomucoidPRO_0000073142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 43
    Disulfide bondi22 ↔ 40
    Disulfide bondi30 ↔ 61
    Disulfide bondi69 ↔ 108
    Disulfide bondi86 ↔ 105
    Disulfide bondi94 ↔ 126
    Disulfide bondi137 ↔ 167
    Disulfide bondi145 ↔ 164
    Disulfide bondi153 ↔ 185
    Glycosylationi174 – 1741N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP68390.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1505027.

    Structurei

    Secondary structure

    1
    185
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi69 – 713
    Beta strandi74 – 763
    Beta strandi82 – 843
    Beta strandi93 – 953
    Beta strandi100 – 1034
    Helixi104 – 11411
    Beta strandi120 – 1245
    Beta strandi132 – 1343
    Helixi137 – 1393
    Beta strandi143 – 1464
    Beta strandi152 – 1543
    Beta strandi159 – 1624
    Helixi163 – 17210
    Turni173 – 1753
    Beta strandi179 – 1835

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CHOX-ray1.80I130-185[»]
    1CSOX-ray1.90I135-185[»]
    1CT0X-ray1.80I135-185[»]
    1CT2X-ray1.65I135-185[»]
    1CT4X-ray1.60I135-185[»]
    1DS2X-ray1.70I135-185[»]
    1DS3X-ray1.65I135-185[»]
    1HJAX-ray2.30I135-185[»]
    1OMTNMR-A130-185[»]
    1OMUNMR-A130-185[»]
    1PPFX-ray1.80I130-185[»]
    1R0RX-ray1.10I135-185[»]
    1SGDX-ray1.80I135-185[»]
    1SGEX-ray1.80I135-185[»]
    1SGNX-ray1.80I135-185[»]
    1SGPX-ray1.40I135-185[»]
    1SGQX-ray1.90I135-185[»]
    1SGRX-ray1.80I135-185[»]
    1SGYX-ray1.80I135-185[»]
    1TURNMR-A130-185[»]
    1TUSNMR-A130-185[»]
    1YU6X-ray1.55C/D1-185[»]
    1Z7KX-ray1.90B65-126[»]
    C12-15[»]
    2GKRX-ray1.16I135-185[»]
    2GKTX-ray1.23I135-185[»]
    2GKVX-ray1.70A/B135-185[»]
    2SGDX-ray1.80I135-185[»]
    2SGEX-ray1.80I135-185[»]
    2SGFX-ray1.75I135-185[»]
    2SGPX-ray1.80I135-185[»]
    2SGQX-ray1.80I135-185[»]
    3SGBX-ray1.80I130-185[»]
    3SGQX-ray1.80I135-185[»]
    ProteinModelPortaliP68390.
    SMRiP68390. Positions 1-61, 65-126, 130-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP68390.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6363Kazal-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini64 – 12865Kazal-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini131 – 18555Kazal-like 3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.

    Sequence similaritiesi

    Contains 3 Kazal-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG006172.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR001239. Prot_inh_Kazal-m.
    [Graphical view]
    PfamiPF00050. Kazal_1. 2 hits.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    PRINTSiPR00290. KAZALINHBTR.
    SMARTiSM00280. KAZAL. 3 hits.
    [Graphical view]
    PROSITEiPS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68390-1 [UniParc]FASTAAdd to Basket

    « Hide

    VEVDCSRFPN TTNEEGKDVL VCTEDLRPIC GTDGVTHSEC LLCAYNIEYG    50
    TNISKEHDGE CREAVPMDCS RYPNTTSEEG KVMILCNKAL NPVCGTDGVT 100
    YDNECVLCAH NLEQGTSVGK KHDGECRKEL AAVSVDCSEY PKPACTLEYR 150
    PLCGSDNKTY GNKCNFCNAV VESNGTLTLS HFGKC 185
    Length:185
    Mass (Da):20,156
    Last modified:July 21, 1986 - v1
    Checksum:i24BB83F5A66A1A76
    GO

    Sequence databases

    PIRiA01238. TITKM.

    Cross-referencesi

    Sequence databases

    PIRi A01238. TITKM.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CHO X-ray 1.80 I 130-185 [» ]
    1CSO X-ray 1.90 I 135-185 [» ]
    1CT0 X-ray 1.80 I 135-185 [» ]
    1CT2 X-ray 1.65 I 135-185 [» ]
    1CT4 X-ray 1.60 I 135-185 [» ]
    1DS2 X-ray 1.70 I 135-185 [» ]
    1DS3 X-ray 1.65 I 135-185 [» ]
    1HJA X-ray 2.30 I 135-185 [» ]
    1OMT NMR - A 130-185 [» ]
    1OMU NMR - A 130-185 [» ]
    1PPF X-ray 1.80 I 130-185 [» ]
    1R0R X-ray 1.10 I 135-185 [» ]
    1SGD X-ray 1.80 I 135-185 [» ]
    1SGE X-ray 1.80 I 135-185 [» ]
    1SGN X-ray 1.80 I 135-185 [» ]
    1SGP X-ray 1.40 I 135-185 [» ]
    1SGQ X-ray 1.90 I 135-185 [» ]
    1SGR X-ray 1.80 I 135-185 [» ]
    1SGY X-ray 1.80 I 135-185 [» ]
    1TUR NMR - A 130-185 [» ]
    1TUS NMR - A 130-185 [» ]
    1YU6 X-ray 1.55 C/D 1-185 [» ]
    1Z7K X-ray 1.90 B 65-126 [» ]
    C 12-15 [» ]
    2GKR X-ray 1.16 I 135-185 [» ]
    2GKT X-ray 1.23 I 135-185 [» ]
    2GKV X-ray 1.70 A/B 135-185 [» ]
    2SGD X-ray 1.80 I 135-185 [» ]
    2SGE X-ray 1.80 I 135-185 [» ]
    2SGF X-ray 1.75 I 135-185 [» ]
    2SGP X-ray 1.80 I 135-185 [» ]
    2SGQ X-ray 1.80 I 135-185 [» ]
    3SGB X-ray 1.80 I 130-185 [» ]
    3SGQ X-ray 1.80 I 135-185 [» ]
    ProteinModelPortali P68390.
    SMRi P68390. Positions 1-61, 65-126, 130-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1505027.

    Protein family/group databases

    Allergomei 2116. Mel g 1.
    MEROPSi I01.001.

    Proteomic databases

    PRIDEi P68390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006172.

    Miscellaneous databases

    EvolutionaryTracei P68390.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR001239. Prot_inh_Kazal-m.
    [Graphical view ]
    Pfami PF00050. Kazal_1. 2 hits.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00290. KAZALINHBTR.
    SMARTi SM00280. KAZAL. 3 hits.
    [Graphical view ]
    PROSITEi PS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of avian ovomucoids."
      Kato I., Kohr W.J., Laskowski M. Jr.
      (In) Magnusson S., Ottesen M., Foltmann B., Dano K., Neurath H. (eds.); Regulatory proteolytic enzymes and their inhibitors, pp.197-206, Pergamon Press, New York (1978)
      Cited for: PROTEIN SEQUENCE.
    2. "Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey."
      Fujinaga M., Read R.J., Sielecki A., Ardelt W., Laskowski M. Jr., James M.N.G.
      Proc. Natl. Acad. Sci. U.S.A. 79:4868-4872(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF THIRD DOMAIN.
    3. Ding J., Qasim M.A., Laskowski M. Jr., James M.N.G.
      Submitted (JUL-1997) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THIRD DOMAIN.
    4. "Conformation of the third domain of turkey ovomucoid in solution. Structural analysis by two-dimensional Overhauser nuclear effect spectroscopy."
      Andrianov A.M.
      Mol. Biol. (Mosk.) 25:1215-1225(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF THIRD DOMAIN.
    5. "Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data."
      Krezel A.M., Darba P., Robertson A.D., Fejzo J., Macura S., Markley J.L.
      J. Mol. Biol. 242:203-214(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF THIRD DOMAIN.

    Entry informationi

    Entry nameiIOVO_MELGA
    AccessioniPrimary (citable) accession number: P68390
    Secondary accession number(s): P01004
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3