Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Envelope glycoprotein K

Gene

gK

Organism
Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Syncytium formation induced by viral infection, Viral primary envelope fusion with host outer nuclear membrane, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein K
Alternative name(s):
Syncytial protein
Gene namesi
Name:gK
ORF Names:UL53
OrganismiHuman herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri36345 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 121ExtracellularSequence analysisAdd BLAST91
Transmembranei122 – 140HelicalSequence analysisAdd BLAST19
Topological domaini141 – 212CytoplasmicSequence analysisAdd BLAST72
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 243ExtracellularSequence analysis10
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 301CytoplasmicSequence analysisAdd BLAST37
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 338ExtracellularSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Add BLAST30
ChainiPRO_000003830231 – 338Envelope glycoprotein KAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi58N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts (via UL20 interaction region) with protein UL20 (via N-terminus); this interaction probably plays a role in the coordinate transport of protein UL20 and gK to the trans-Golgi network (TGN), and is required for the cell surface expression of gK.By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 121Involved in fusionSequence analysisAdd BLAST91
Regioni265 – 301Interaction with UL20Sequence analysisAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR002567. GK.
[Graphical view]
PfamiPF01621. Fusion_gly_K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVRSLQHL STVVLITAYG LVLVWYTVFG ASPLHRCIYA VRPTGTNNDT
60 70 80 90 100
ALVWMKMNQT LLFLGAPTHP PNGGWRNHAH ICYANLIAGR VVPFQVPPDA
110 120 130 140 150
MNRRIMNVHE AVNCLETLWY TRVRLVVVGW FLYLAFVALH QRRCMFGVVS
160 170 180 190 200
PAHKMVAPAT YLLNYAGRIV SSVFLQYPYT KITRLLCELS VQRQNLVQLF
210 220 230 240 250
ETDPVTFLYH RPAIGVIVGC ELMLRFVAVG LIVGTAFISR GACAITYPLF
260 270 280 290 300
LTITTWCFVS TIGLTELYCI LRRGPAPKNA DKAAAPGRSK GLSGVCGRCC
310 320 330
SIILSGIAVR LCYIAVVAGV VLVALHYEQE IQRRLFDV
Length:338
Mass (Da):37,573
Last modified:November 9, 2004 - v1
Checksum:iDC69FE77084E84A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51910 Genomic DNA. Translation: AAB24732.1.
RefSeqiYP_009137129.1. NC_001806.2.

Genome annotation databases

GeneIDi2703425.
KEGGivg:2703425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51910 Genomic DNA. Translation: AAB24732.1.
RefSeqiYP_009137129.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703425.
KEGGivg:2703425.

Family and domain databases

InterProiIPR002567. GK.
[Graphical view]
PfamiPF01621. Fusion_gly_K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGK_HHV1R
AccessioniPrimary (citable) accession number: P68333
Secondary accession number(s): P10237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.