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P68333

- GK_HHV1R

UniProt

P68333 - GK_HHV1R

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Protein

Envelope glycoprotein K

Gene

gK

Organism
Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. fusion of viral membrane with host outer nuclear membrane Source: UniProtKB-KW
  3. positive regulation of syncytium formation by virus Source: UniProtKB-KW
  4. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Syncytium formation induced by viral infection, Viral primary envelope fusion with host outer nuclear membrane, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein K
Alternative name(s):
Syncytial protein
Gene namesi
Name:gK
ORF Names:UL53
OrganismiHuman herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri36345 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Host cell membrane By similarity; Multi-pass membrane protein By similarity. Host endosome membrane By similarity; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Probably not present in extracellular virions (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 12191ExtracellularSequence AnalysisAdd
BLAST
Transmembranei122 – 14019HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 21272CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Topological domaini234 – 24310ExtracellularSequence Analysis
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 30137CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST
Topological domaini323 – 33816ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell endosome Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell plasma membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Add
BLAST
Chaini31 – 338308Envelope glycoprotein KPRO_0000038302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts (via UL20 interaction region) with protein UL20 (via N-terminus); this interaction probably plays a role in the coordinate transport of protein UL20 and gK to the trans-Golgi network (TGN), and is required for the cell surface expression of gK.By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 12191Involved in fusionSequence AnalysisAdd
BLAST
Regioni265 – 30137Interaction with UL20Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR002567. Fusion_gly_K.
[Graphical view]
PfamiPF01621. Fusion_gly_K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68333-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLAVRSLQHL STVVLITAYG LVLVWYTVFG ASPLHRCIYA VRPTGTNNDT
60 70 80 90 100
ALVWMKMNQT LLFLGAPTHP PNGGWRNHAH ICYANLIAGR VVPFQVPPDA
110 120 130 140 150
MNRRIMNVHE AVNCLETLWY TRVRLVVVGW FLYLAFVALH QRRCMFGVVS
160 170 180 190 200
PAHKMVAPAT YLLNYAGRIV SSVFLQYPYT KITRLLCELS VQRQNLVQLF
210 220 230 240 250
ETDPVTFLYH RPAIGVIVGC ELMLRFVAVG LIVGTAFISR GACAITYPLF
260 270 280 290 300
LTITTWCFVS TIGLTELYCI LRRGPAPKNA DKAAAPGRSK GLSGVCGRCC
310 320 330
SIILSGIAVR LCYIAVVAGV VLVALHYEQE IQRRLFDV
Length:338
Mass (Da):37,573
Last modified:November 9, 2004 - v1
Checksum:iDC69FE77084E84A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51910 Genomic DNA. Translation: AAB24732.1.
RefSeqiNP_044656.1. NC_001806.1.

Genome annotation databases

GeneIDi2703425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51910 Genomic DNA. Translation: AAB24732.1 .
RefSeqi NP_044656.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703425.

Family and domain databases

InterProi IPR002567. Fusion_gly_K.
[Graphical view ]
Pfami PF01621. Fusion_gly_K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mutations in the UL53 gene of HSV-1 abolish virus neurovirulence to mice by the intracerebral route of infection."
    Moyal M., Berkowitz C., Rosen-Wolff A., Darai G., Becker Y.
    Virus Res. 26:99-112(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGK_HHV1R
AccessioniPrimary (citable) accession number: P68333
Secondary accession number(s): P10237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3