Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P68333 (GK_HHV1R) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein K
Alternative name(s):
Syncytial protein
Gene names
Name:gK
ORF Names:UL53
OrganismHuman herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier36345 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes By similarity.

Subunit structure

Interacts (via UL20 interaction region) with protein UL20 (via N-terminus); this interaction probably plays a role in the coordinate transport of protein UL20 and gK to the trans-Golgi network (TGN), and is required for the cell surface expression of gK By similarity.

Subcellular location

Host cell membrane; Multi-pass membrane protein By similarity. Host endosome membrane; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane; Multi-pass membrane protein By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Probably not present in extracellular virions By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the alphaherpesvirinae glycoprotein K family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030
Chain31 – 338308Envelope glycoprotein K
PRO_0000038302

Regions

Topological domain31 – 12191Extracellular Potential
Transmembrane122 – 14019Helical; Potential
Topological domain141 – 21272Cytoplasmic Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 24310Extracellular Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 30137Cytoplasmic Potential
Transmembrane302 – 32221Helical; Potential
Topological domain323 – 33816Extracellular Potential
Region31 – 12191Involved in fusion Potential
Region265 – 30137Interaction with UL20 Potential

Amino acid modifications

Glycosylation481N-linked (GlcNAc...); by host Potential
Glycosylation581N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P68333 [UniParc].

Last modified November 9, 2004. Version 1.
Checksum: DC69FE77084E84A1

FASTA33837,573
        10         20         30         40         50         60 
MLAVRSLQHL STVVLITAYG LVLVWYTVFG ASPLHRCIYA VRPTGTNNDT ALVWMKMNQT 

        70         80         90        100        110        120 
LLFLGAPTHP PNGGWRNHAH ICYANLIAGR VVPFQVPPDA MNRRIMNVHE AVNCLETLWY 

       130        140        150        160        170        180 
TRVRLVVVGW FLYLAFVALH QRRCMFGVVS PAHKMVAPAT YLLNYAGRIV SSVFLQYPYT 

       190        200        210        220        230        240 
KITRLLCELS VQRQNLVQLF ETDPVTFLYH RPAIGVIVGC ELMLRFVAVG LIVGTAFISR 

       250        260        270        280        290        300 
GACAITYPLF LTITTWCFVS TIGLTELYCI LRRGPAPKNA DKAAAPGRSK GLSGVCGRCC 

       310        320        330 
SIILSGIAVR LCYIAVVAGV VLVALHYEQE IQRRLFDV 

« Hide

References

[1]"Mutations in the UL53 gene of HSV-1 abolish virus neurovirulence to mice by the intracerebral route of infection."
Moyal M., Berkowitz C., Rosen-Wolff A., Darai G., Becker Y.
Virus Res. 26:99-112(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S51910 Genomic DNA. Translation: AAB24732.1.
RefSeqNP_044656.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703425.

Phylogenomic databases

ProtClustDBPHA3276.

Family and domain databases

InterProIPR002567. Fusion_gly_K.
[Graphical view]
PfamPF01621. Fusion_gly_K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGK_HHV1R
AccessionPrimary (citable) accession number: P68333
Secondary accession number(s): P10237
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families