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P68333

- GK_HHV1R

UniProt

P68333 - GK_HHV1R

Protein

Envelope glycoprotein K

Gene

gK

Organism
Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (09 Nov 2004)
      Previous versions | rss
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    Functioni

    Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. fusion of viral membrane with host outer nuclear membrane Source: UniProtKB-KW
    3. positive regulation of syncytium formation by virus Source: UniProtKB-KW
    4. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Syncytium formation induced by viral infection, Viral primary envelope fusion with host outer nuclear membrane, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein K
    Alternative name(s):
    Syncytial protein
    Gene namesi
    Name:gK
    ORF Names:UL53
    OrganismiHuman herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri36345 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Host cell membrane By similarity; Multi-pass membrane protein By similarity. Host endosome membrane By similarity; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
    Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with UL20 to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Cell surface expression of gK is required for virus-induced cell-to-cell fusion. Probably not present in extracellular virions By similarity.By similarity

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. host cell plasma membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. intracellular Source: GOC

    Keywords - Cellular componenti

    Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Add
    BLAST
    Chaini31 – 338308Envelope glycoprotein KPRO_0000038302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi58 – 581N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts (via UL20 interaction region) with protein UL20 (via N-terminus); this interaction probably plays a role in the coordinate transport of protein UL20 and gK to the trans-Golgi network (TGN), and is required for the cell surface expression of gK.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 12191ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 21272CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini234 – 24310ExtracellularSequence Analysis
    Topological domaini265 – 30137CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 33816ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei122 – 14019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni31 – 12191Involved in fusionSequence AnalysisAdd
    BLAST
    Regioni265 – 30137Interaction with UL20Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR002567. Fusion_gly_K.
    [Graphical view]
    PfamiPF01621. Fusion_gly_K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P68333-1 [UniParc]FASTAAdd to Basket

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    MLAVRSLQHL STVVLITAYG LVLVWYTVFG ASPLHRCIYA VRPTGTNNDT    50
    ALVWMKMNQT LLFLGAPTHP PNGGWRNHAH ICYANLIAGR VVPFQVPPDA 100
    MNRRIMNVHE AVNCLETLWY TRVRLVVVGW FLYLAFVALH QRRCMFGVVS 150
    PAHKMVAPAT YLLNYAGRIV SSVFLQYPYT KITRLLCELS VQRQNLVQLF 200
    ETDPVTFLYH RPAIGVIVGC ELMLRFVAVG LIVGTAFISR GACAITYPLF 250
    LTITTWCFVS TIGLTELYCI LRRGPAPKNA DKAAAPGRSK GLSGVCGRCC 300
    SIILSGIAVR LCYIAVVAGV VLVALHYEQE IQRRLFDV 338
    Length:338
    Mass (Da):37,573
    Last modified:November 9, 2004 - v1
    Checksum:iDC69FE77084E84A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S51910 Genomic DNA. Translation: AAB24732.1.
    RefSeqiNP_044656.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S51910 Genomic DNA. Translation: AAB24732.1 .
    RefSeqi NP_044656.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703425.

    Family and domain databases

    InterProi IPR002567. Fusion_gly_K.
    [Graphical view ]
    Pfami PF01621. Fusion_gly_K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in the UL53 gene of HSV-1 abolish virus neurovirulence to mice by the intracerebral route of infection."
      Moyal M., Berkowitz C., Rosen-Wolff A., Darai G., Becker Y.
      Virus Res. 26:99-112(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGK_HHV1R
    AccessioniPrimary (citable) accession number: P68333
    Secondary accession number(s): P10237
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: November 9, 2004
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3