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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190Thyroid hormoneBy similarity1
Binding sitei228Thyroid hormoneBy similarity1
Binding sitei239Thyroid hormone; via amide nitrogenBy similarity1
Binding sitei343Thyroid hormoneBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 89Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri15 – 35NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri53 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene namesi
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: AgBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534541 – 369Thyroid hormone receptor betaAdd BLAST369

Proteomic databases

PaxDbiP68306.

Expressioni

Gene expression databases

BgeeiENSGALG00000011294.
ExpressionAtlasiP68306. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASXL1Q8IXJ92EBI-5743841,EBI-1646500From Homo sapiens.

Protein-protein interaction databases

IntActiP68306. 3 interactors.
STRINGi9031.ENSGALP00000018402.

Structurei

3D structure databases

ProteinModelPortaliP68306.
SMRiP68306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 14ModulatingSequence analysisAdd BLAST14
Regioni132 – 369Ligand-bindingAdd BLAST238

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 35NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri53 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00870000136372.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP68306.
KOiK08362.
PhylomeDBiP68306.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P68306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT
60 70 80 90 100
YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI
110 120 130 140 150
EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK
160 170 180 190 200
RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM
210 220 230 240 250
FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK
260 270 280 290 300
NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI
310 320 330 340 350
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM
360
KVECPTELFP PLFLEVFED
Length:369
Mass (Da):42,097
Last modified:October 25, 2004 - v1
Checksum:i36FC16B41383138F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116I → M (PubMed:1707280).Curated1
Sequence conflicti117G → V (PubMed:1707280).Curated1
Sequence conflicti144G → V in AAA49107 (PubMed:1707280).Curated1
Sequence conflicti202C → L in AAA49107 (PubMed:1707280).Curated1
Sequence conflicti215G → V in AAA49107 (PubMed:1707280).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRiS09625. TVCHTB.
RefSeqiNP_990778.2. NM_205447.2.
XP_015136810.1. XM_015281324.1.
XP_015136811.1. XM_015281325.1.
XP_015136812.1. XM_015281326.1.
UniGeneiGga.609.

Genome annotation databases

EnsembliENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
ENSGALT00000087313; ENSGALP00000060050; ENSGALG00000011294.
GeneIDi396431.
KEGGigga:396431.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTHB_CHICK
AccessioniPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: July 5, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families