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P68306

- THB_CHICK

UniProt

P68306 - THB_CHICK

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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901Thyroid hormoneBy similarity
Binding sitei228 – 2281Thyroid hormoneBy similarity
Binding sitei239 – 2391Thyroid hormone; via amide nitrogenBy similarity
Binding sitei343 – 3431Thyroid hormoneBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 8975Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. sequence-specific DNA binding Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. thyroid hormone binding Source: UniProtKB
  5. thyroid hormone receptor activity Source: UniProtKB
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. female courtship behavior Source: Ensembl
  2. intracellular receptor signaling pathway Source: GOC
  3. negative regulation of female receptivity Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. organ morphogenesis Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of heart contraction Source: Ensembl
  8. sensory perception of sound Source: Ensembl
  9. Type I pneumocyte differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene namesi
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Thyroid hormone receptor betaPRO_0000053454Add
BLAST

Proteomic databases

PaxDbiP68306.

Expressioni

Gene expression databases

ExpressionAtlasiP68306. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASXL1Q8IXJ92EBI-5743841,EBI-1646500From a different organism.

Protein-protein interaction databases

IntActiP68306. 3 interactions.
STRINGi9031.ENSGALP00000018402.

Structurei

3D structure databases

ProteinModelPortaliP68306.
SMRiP68306. Positions 12-100, 119-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1414ModulatingSequence AnalysisAdd
BLAST
Regioni132 – 369238Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00760000118837.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP68306.
KOiK08362.
OrthoDBiEOG7TBC2V.
PhylomeDBiP68306.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68306-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT
60 70 80 90 100
YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI
110 120 130 140 150
EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK
160 170 180 190 200
RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM
210 220 230 240 250
FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK
260 270 280 290 300
NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI
310 320 330 340 350
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM
360
KVECPTELFP PLFLEVFED
Length:369
Mass (Da):42,097
Last modified:October 25, 2004 - v1
Checksum:i36FC16B41383138F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161I → M(PubMed:1707280)Curated
Sequence conflicti117 – 1171G → V(PubMed:1707280)Curated
Sequence conflicti144 – 1441G → V in AAA49107. (PubMed:1707280)Curated
Sequence conflicti202 – 2021C → L in AAA49107. (PubMed:1707280)Curated
Sequence conflicti215 – 2151G → V in AAA49107. (PubMed:1707280)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRiS09625. TVCHTB.
RefSeqiNP_990778.2. NM_205447.2.
UniGeneiGga.609.

Genome annotation databases

EnsembliENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
GeneIDi396431.
KEGGigga:396431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17504 mRNA. Translation: CAA35544.1 .
M65207 mRNA. Translation: AAA49107.1 .
Z50188 mRNA. Translation: CAA90566.1 .
PIRi S09625. TVCHTB.
RefSeqi NP_990778.2. NM_205447.2.
UniGenei Gga.609.

3D structure databases

ProteinModelPortali P68306.
SMRi P68306. Positions 12-100, 119-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P68306. 3 interactions.
STRINGi 9031.ENSGALP00000018402.

Proteomic databases

PaxDbi P68306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000018423 ; ENSGALP00000018401 ; ENSGALG00000011294 .
ENSGALT00000031162 ; ENSGALP00000030526 ; ENSGALG00000011294 .
GeneIDi 396431.
KEGGi gga:396431.

Organism-specific databases

CTDi 7068.

Phylogenomic databases

eggNOGi NOG272726.
GeneTreei ENSGT00760000118837.
HOGENOMi HOG000010313.
HOVERGENi HBG005606.
InParanoidi P68306.
KOi K08362.
OrthoDBi EOG7TBC2V.
PhylomeDBi P68306.

Miscellaneous databases

NextBioi 20816472.
PROi P68306.

Gene expression databases

ExpressionAtlasi P68306. baseline.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes."
    Forest D., Sjoeberg M., Vennstroem B.
    EMBO J. 9:1519-1528(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SPAFAS.
    Tissue: Kidney.
  2. "Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor."
    Showers M.O., Darling D.S., Kieffer G.D., Chin W.W.
    DNA Cell Biol. 10:211-221(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling."
    Lachuer J.L., Legras C.L., Ronfort C.R., Barges S.B., Cohen-Adad F.C., Quivet L.Q., Duchamp C.D., Verdier G.V., Barre H.B.
    Biochim. Biophys. Acta 1310:127-130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTHB_CHICK
AccessioniPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3