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P68306

- THB_CHICK

UniProt

P68306 - THB_CHICK

Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei190 – 1901Thyroid hormoneBy similarity
    Binding sitei228 – 2281Thyroid hormoneBy similarity
    Binding sitei239 – 2391Thyroid hormone; via amide nitrogenBy similarity
    Binding sitei343 – 3431Thyroid hormoneBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi15 – 8975Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: InterPro
    4. steroid hormone receptor activity Source: InterPro
    5. thyroid hormone binding Source: UniProtKB
    6. thyroid hormone receptor activity Source: UniProtKB
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. female courtship behavior Source: Ensembl
    2. intracellular receptor signaling pathway Source: GOC
    3. negative regulation of female receptivity Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. organ morphogenesis Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. regulation of heart contraction Source: Ensembl
    8. sensory perception of sound Source: Ensembl
    9. Type I pneumocyte differentiation Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyroid hormone receptor beta
    Alternative name(s):
    Nuclear receptor subfamily 1 group A member 2
    Gene namesi
    Name:THRB
    Synonyms:C-ERBA-BETA, NR1A2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Thyroid hormone receptor betaPRO_0000053454Add
    BLAST

    Proteomic databases

    PaxDbiP68306.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASXL1Q8IXJ92EBI-5743841,EBI-1646500From a different organism.

    Protein-protein interaction databases

    IntActiP68306. 3 interactions.
    STRINGi9031.ENSGALP00000018402.

    Structurei

    3D structure databases

    ProteinModelPortaliP68306.
    SMRiP68306. Positions 12-100, 119-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1414ModulatingSequence AnalysisAdd
    BLAST
    Regioni132 – 369238Ligand-bindingAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG272726.
    GeneTreeiENSGT00740000114969.
    HOGENOMiHOG000010313.
    HOVERGENiHBG005606.
    KOiK08362.
    OrthoDBiEOG7TBC2V.
    PhylomeDBiP68306.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT    50
    YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI 100
    EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK 150
    RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM 200
    FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK 250
    NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI 300
    EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM 350
    KVECPTELFP PLFLEVFED 369
    Length:369
    Mass (Da):42,097
    Last modified:October 25, 2004 - v1
    Checksum:i36FC16B41383138F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161I → M(PubMed:1707280)Curated
    Sequence conflicti117 – 1171G → V(PubMed:1707280)Curated
    Sequence conflicti144 – 1441G → V in AAA49107. (PubMed:1707280)Curated
    Sequence conflicti202 – 2021C → L in AAA49107. (PubMed:1707280)Curated
    Sequence conflicti215 – 2151G → V in AAA49107. (PubMed:1707280)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17504 mRNA. Translation: CAA35544.1.
    M65207 mRNA. Translation: AAA49107.1.
    Z50188 mRNA. Translation: CAA90566.1.
    PIRiS09625. TVCHTB.
    RefSeqiNP_990778.2. NM_205447.2.
    UniGeneiGga.609.

    Genome annotation databases

    EnsembliENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
    ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
    GeneIDi396431.
    KEGGigga:396431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17504 mRNA. Translation: CAA35544.1 .
    M65207 mRNA. Translation: AAA49107.1 .
    Z50188 mRNA. Translation: CAA90566.1 .
    PIRi S09625. TVCHTB.
    RefSeqi NP_990778.2. NM_205447.2.
    UniGenei Gga.609.

    3D structure databases

    ProteinModelPortali P68306.
    SMRi P68306. Positions 12-100, 119-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P68306. 3 interactions.
    STRINGi 9031.ENSGALP00000018402.

    Proteomic databases

    PaxDbi P68306.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000018423 ; ENSGALP00000018401 ; ENSGALG00000011294 .
    ENSGALT00000031162 ; ENSGALP00000030526 ; ENSGALG00000011294 .
    GeneIDi 396431.
    KEGGi gga:396431.

    Organism-specific databases

    CTDi 7068.

    Phylogenomic databases

    eggNOGi NOG272726.
    GeneTreei ENSGT00740000114969.
    HOGENOMi HOG000010313.
    HOVERGENi HBG005606.
    KOi K08362.
    OrthoDBi EOG7TBC2V.
    PhylomeDBi P68306.

    Miscellaneous databases

    NextBioi 20816472.
    PROi P68306.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes."
      Forest D., Sjoeberg M., Vennstroem B.
      EMBO J. 9:1519-1528(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: SPAFAS.
      Tissue: Kidney.
    2. "Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor."
      Showers M.O., Darling D.S., Kieffer G.D., Chin W.W.
      DNA Cell Biol. 10:211-221(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling."
      Lachuer J.L., Legras C.L., Ronfort C.R., Barges S.B., Cohen-Adad F.C., Quivet L.Q., Duchamp C.D., Verdier G.V., Barre H.B.
      Biochim. Biophys. Acta 1310:127-130(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiTHB_CHICK
    AccessioniPrimary (citable) accession number: P68306
    Secondary accession number(s): P18112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3