Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190Thyroid hormoneBy similarity1
Binding sitei228Thyroid hormoneBy similarity1
Binding sitei239Thyroid hormone; via amide nitrogenBy similarity1
Binding sitei343Thyroid hormoneBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 89Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri15 – 35NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri53 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene namesi
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534541 – 369Thyroid hormone receptor betaAdd BLAST369

Proteomic databases

PaxDbiP68306

Expressioni

Gene expression databases

BgeeiENSGALG00000011294
ExpressionAtlasiP68306 baseline

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASXL1Q8IXJ92EBI-5743841,EBI-1646500From Homo sapiens.

Protein-protein interaction databases

IntActiP68306, 3 interactors
STRINGi9031.ENSGALP00000018402

Structurei

3D structure databases

ProteinModelPortaliP68306
SMRiP68306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 369NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 14ModulatingSequence analysisAdd BLAST14

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 35NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri53 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP68306
KOiK08362
PhylomeDBiP68306

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P68306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT
60 70 80 90 100
YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI
110 120 130 140 150
EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK
160 170 180 190 200
RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM
210 220 230 240 250
FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK
260 270 280 290 300
NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI
310 320 330 340 350
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM
360
KVECPTELFP PLFLEVFED
Length:369
Mass (Da):42,097
Last modified:October 25, 2004 - v1
Checksum:i36FC16B41383138F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116I → M (PubMed:1707280).Curated1
Sequence conflicti117G → V (PubMed:1707280).Curated1
Sequence conflicti144G → V in AAA49107 (PubMed:1707280).Curated1
Sequence conflicti202C → L in AAA49107 (PubMed:1707280).Curated1
Sequence conflicti215G → V in AAA49107 (PubMed:1707280).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17504 mRNA Translation: CAA35544.1
M65207 mRNA Translation: AAA49107.1
Z50188 mRNA Translation: CAA90566.1
PIRiS09625 TVCHTB
RefSeqiNP_990778.2, NM_205447.2
XP_015136810.1, XM_015281324.1
XP_015136811.1, XM_015281325.1
XP_015136812.1, XM_015281326.1
UniGeneiGga.609

Genome annotation databases

EnsembliENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294
ENSGALT00000087313; ENSGALP00000060050; ENSGALG00000011294
GeneIDi396431
KEGGigga:396431

Similar proteinsi

Entry informationi

Entry nameiTHB_CHICK
AccessioniPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health