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P68306

- THB_CHICK

UniProt

P68306 - THB_CHICK

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Protein
Thyroid hormone receptor beta
Gene
THRB, C-ERBA-BETA, NR1A2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901Thyroid hormone By similarity
Binding sitei228 – 2281Thyroid hormone By similarity
Binding sitei239 – 2391Thyroid hormone; via amide nitrogen By similarity
Binding sitei343 – 3431Thyroid hormone By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 8975Nuclear receptor
Add
BLAST
Zinc fingeri15 – 3521NR C4-type
Add
BLAST
Zinc fingeri53 – 7725NR C4-type
Add
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: InterPro
  4. steroid hormone receptor activity Source: InterPro
  5. thyroid hormone binding Source: UniProtKB
  6. thyroid hormone receptor activity Source: UniProtKB
  7. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. Type I pneumocyte differentiation Source: Ensembl
  2. female courtship behavior Source: Ensembl
  3. intracellular receptor signaling pathway Source: GOC
  4. negative regulation of female receptivity Source: Ensembl
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. organ morphogenesis Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. regulation of heart contraction Source: Ensembl
  9. sensory perception of sound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene namesi
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Thyroid hormone receptor beta
PRO_0000053454Add
BLAST

Proteomic databases

PaxDbiP68306.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASXL1Q8IXJ92EBI-5743841,EBI-1646500From a different organism.

Protein-protein interaction databases

IntActiP68306. 3 interactions.
STRINGi9031.ENSGALP00000018402.

Structurei

3D structure databases

ProteinModelPortaliP68306.
SMRiP68306. Positions 12-100, 119-368.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1414Modulating Reviewed prediction
Add
BLAST
Regioni132 – 369238Ligand-binding
Add
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00740000114969.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
KOiK08362.
OrthoDBiEOG7TBC2V.
PhylomeDBiP68306.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68306-1 [UniParc]FASTAAdd to Basket

« Hide

MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT    50
YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI 100
EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK 150
RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM 200
FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK 250
NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI 300
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM 350
KVECPTELFP PLFLEVFED 369
Length:369
Mass (Da):42,097
Last modified:October 25, 2004 - v1
Checksum:i36FC16B41383138F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161I → M1 Publication
Sequence conflicti117 – 1171G → V1 Publication
Sequence conflicti144 – 1441G → V in AAA49107. 1 Publication
Sequence conflicti202 – 2021C → L in AAA49107. 1 Publication
Sequence conflicti215 – 2151G → V in AAA49107. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRiS09625. TVCHTB.
RefSeqiNP_990778.2. NM_205447.2.
UniGeneiGga.609.

Genome annotation databases

EnsembliENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
GeneIDi396431.
KEGGigga:396431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17504 mRNA. Translation: CAA35544.1 .
M65207 mRNA. Translation: AAA49107.1 .
Z50188 mRNA. Translation: CAA90566.1 .
PIRi S09625. TVCHTB.
RefSeqi NP_990778.2. NM_205447.2.
UniGenei Gga.609.

3D structure databases

ProteinModelPortali P68306.
SMRi P68306. Positions 12-100, 119-368.
ModBasei Search...

Protein-protein interaction databases

IntActi P68306. 3 interactions.
STRINGi 9031.ENSGALP00000018402.

Proteomic databases

PaxDbi P68306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000018423 ; ENSGALP00000018401 ; ENSGALG00000011294 .
ENSGALT00000031162 ; ENSGALP00000030526 ; ENSGALG00000011294 .
GeneIDi 396431.
KEGGi gga:396431.

Organism-specific databases

CTDi 7068.

Phylogenomic databases

eggNOGi NOG272726.
GeneTreei ENSGT00740000114969.
HOGENOMi HOG000010313.
HOVERGENi HBG005606.
KOi K08362.
OrthoDBi EOG7TBC2V.
PhylomeDBi P68306.

Miscellaneous databases

NextBioi 20816472.
PROi P68306.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes."
    Forest D., Sjoeberg M., Vennstroem B.
    EMBO J. 9:1519-1528(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SPAFAS.
    Tissue: Kidney.
  2. "Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor."
    Showers M.O., Darling D.S., Kieffer G.D., Chin W.W.
    DNA Cell Biol. 10:211-221(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling."
    Lachuer J.L., Legras C.L., Ronfort C.R., Barges S.B., Cohen-Adad F.C., Quivet L.Q., Duchamp C.D., Verdier G.V., Barre H.B.
    Biochim. Biophys. Acta 1310:127-130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTHB_CHICK
AccessioniPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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