Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P68306 (THB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene names
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Subcellular location

Nucleus.

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processType I pneumocyte differentiation

Inferred from electronic annotation. Source: Ensembl

female courtship behavior

Inferred from electronic annotation. Source: Ensembl

intracellular receptor signaling pathway

Inferred from sequence or structural similarity. Source: GOC

negative regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of heart contraction

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionchromatin DNA binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 16606617. Source: IntAct

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

thyroid hormone binding

Inferred from sequence or structural similarity. Source: UniProtKB

thyroid hormone receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ASXL1Q8IXJ92EBI-5743841,EBI-1646500From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Thyroid hormone receptor beta
PRO_0000053454

Regions

DNA binding15 – 8975Nuclear receptor
Zinc finger15 – 3521NR C4-type
Zinc finger53 – 7725NR C4-type
Region1 – 1414Modulating Potential
Region132 – 369238Ligand-binding

Sites

Binding site1901Thyroid hormone By similarity
Binding site2281Thyroid hormone By similarity
Binding site2391Thyroid hormone; via amide nitrogen By similarity
Binding site3431Thyroid hormone By similarity

Experimental info

Sequence conflict1161I → M Ref.2
Sequence conflict1171G → V Ref.2
Sequence conflict1441G → V in AAA49107. Ref.2
Sequence conflict2021C → L in AAA49107. Ref.2
Sequence conflict2151G → V in AAA49107. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P68306 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 36FC16B41383138F

FASTA36942,097
        10         20         30         40         50         60 
MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT YSCKYEGKCV 

        70         80         90        100        110        120 
IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI EENREKRRRE ELQKTIGHKP 

       130        140        150        160        170        180 
EPTDEEWELI KIVTEAHVAT NAQGSHWKQK RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF 

       190        200        210        220        230        240 
TKIITPAITR VVDFAKKLPM FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG 

       250        260        270        280        290        300 
EMAVTRGQLK NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI 

       310        320        330        340        350        360 
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM KVECPTELFP 


PLFLEVFED 

« Hide

References

[1]"Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes."
Forest D., Sjoeberg M., Vennstroem B.
EMBO J. 9:1519-1528(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SPAFAS.
Tissue: Kidney.
[2]"Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor."
Showers M.O., Darling D.S., Kieffer G.D., Chin W.W.
DNA Cell Biol. 10:211-221(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling."
Lachuer J.L., Legras C.L., Ronfort C.R., Barges S.B., Cohen-Adad F.C., Quivet L.Q., Duchamp C.D., Verdier G.V., Barre H.B.
Biochim. Biophys. Acta 1310:127-130(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRTVCHTB. S09625.
RefSeqNP_990778.2. NM_205447.2.
UniGeneGga.609.

3D structure databases

ProteinModelPortalP68306.
SMRP68306. Positions 12-100, 119-368.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP68306. 3 interactions.
STRING9031.ENSGALP00000018402.

Proteomic databases

PaxDbP68306.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
GeneID396431.
KEGGgga:396431.

Organism-specific databases

CTD7068.

Phylogenomic databases

eggNOGNOG272726.
GeneTreeENSGT00740000114969.
HOGENOMHOG000010313.
HOVERGENHBG005606.
KOK08362.
OrthoDBEOG7TBC2V.
PhylomeDBP68306.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816472.
PROP68306.

Entry information

Entry nameTHB_CHICK
AccessionPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families