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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901Thyroid hormoneBy similarity
Binding sitei228 – 2281Thyroid hormoneBy similarity
Binding sitei239 – 2391Thyroid hormone; via amide nitrogenBy similarity
Binding sitei343 – 3431Thyroid hormoneBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 8975Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_347689. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
Gene namesi
Name:THRB
Synonyms:C-ERBA-BETA, NR1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Thyroid hormone receptor betaPRO_0000053454Add
BLAST

Proteomic databases

PaxDbiP68306.

Expressioni

Gene expression databases

ExpressionAtlasiP68306. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASXL1Q8IXJ92EBI-5743841,EBI-1646500From a different organism.

Protein-protein interaction databases

IntActiP68306. 3 interactions.
STRINGi9031.ENSGALP00000018402.

Structurei

3D structure databases

ProteinModelPortaliP68306.
SMRiP68306. Positions 12-100, 119-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1414ModulatingSequence AnalysisAdd
BLAST
Regioni132 – 369238Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 3521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP68306.
OrthoDBiEOG7TBC2V.
PhylomeDBiP68306.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYIPSYLD KDELCVVCGD KATGYHYRCI TCEGCKGFFR RTIQKNLHPT
60 70 80 90 100
YSCKYEGKCV IDKVTRNQCQ ECRFKKCIFV GMATDLVLDD SKRLAKRKLI
110 120 130 140 150
EENREKRRRE ELQKTIGHKP EPTDEEWELI KIVTEAHVAT NAQGSHWKQK
160 170 180 190 200
RKFLPEDIGQ APIVNAPEGG KVDLEAFSQF TKIITPAITR VVDFAKKLPM
210 220 230 240 250
FCELPCEDQI ILLKGCCMEI MSLRAAVRYD PESETLTLNG EMAVTRGQLK
260 270 280 290 300
NGGLGVVSDA IFDLGMSLSS FNLDDTEVAL LQAVLLMSSD RPGLVCVERI
310 320 330 340 350
EKCQEGFLLA FEHYINYRKH HVAHFWPKLL MKVTDLRMIG ACHASRFLHM
360
KVECPTELFP PLFLEVFED
Length:369
Mass (Da):42,097
Last modified:October 25, 2004 - v1
Checksum:i36FC16B41383138F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161I → M (PubMed:1707280).Curated
Sequence conflicti117 – 1171G → V (PubMed:1707280).Curated
Sequence conflicti144 – 1441G → V in AAA49107 (PubMed:1707280).Curated
Sequence conflicti202 – 2021C → L in AAA49107 (PubMed:1707280).Curated
Sequence conflicti215 – 2151G → V in AAA49107 (PubMed:1707280).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRiS09625. TVCHTB.
RefSeqiNP_990778.2. NM_205447.2.
UniGeneiGga.609.

Genome annotation databases

EnsembliENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
GeneIDi396431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17504 mRNA. Translation: CAA35544.1.
M65207 mRNA. Translation: AAA49107.1.
Z50188 mRNA. Translation: CAA90566.1.
PIRiS09625. TVCHTB.
RefSeqiNP_990778.2. NM_205447.2.
UniGeneiGga.609.

3D structure databases

ProteinModelPortaliP68306.
SMRiP68306. Positions 12-100, 119-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP68306. 3 interactions.
STRINGi9031.ENSGALP00000018402.

Proteomic databases

PaxDbiP68306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018423; ENSGALP00000018401; ENSGALG00000011294.
ENSGALT00000031162; ENSGALP00000030526; ENSGALG00000011294.
GeneIDi396431.

Organism-specific databases

CTDi7068.

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP68306.
OrthoDBiEOG7TBC2V.
PhylomeDBiP68306.

Enzyme and pathway databases

ReactomeiREACT_347689. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi20816472.
PROiP68306.

Gene expression databases

ExpressionAtlasiP68306. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes."
    Forest D., Sjoeberg M., Vennstroem B.
    EMBO J. 9:1519-1528(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SPAFAS.
    Tissue: Kidney.
  2. "Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor."
    Showers M.O., Darling D.S., Kieffer G.D., Chin W.W.
    DNA Cell Biol. 10:211-221(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling."
    Lachuer J.L., Legras C.L., Ronfort C.R., Barges S.B., Cohen-Adad F.C., Quivet L.Q., Duchamp C.D., Verdier G.V., Barre H.B.
    Biochim. Biophys. Acta 1310:127-130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTHB_CHICK
AccessioniPrimary (citable) accession number: P68306
Secondary accession number(s): P18112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.