Reviewed,
UniProtKB/Swiss-Prot P68303 (MT2_MACFA)
Last modified
November 24, 2009.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Metallothionein-2 Short name=MT-2 Alternative name(s): Metallothionein-II Short name=MT-II | ||
| Gene names |
| ||
| Organism | Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) | ||
| Taxonomic identifier | 9541 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Miscellaneous | This metallothionein binds zinc. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Cadmium Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Molecular function | cadmium ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein-2 | PRO_0000197246 | |||||
Regions | |||||||||
| Region | 1 – 29 | 29 | Beta | ||||||
| Region | 20 – 25 | 6 | Antigenic epitope | ||||||
| Region | 30 – 61 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Cluster B | ||||||
| Metal binding | 7 | 1 | Cluster B | ||||||
| Metal binding | 13 | 1 | Cluster B | ||||||
| Metal binding | 15 | 1 | Cluster B | ||||||
| Metal binding | 19 | 1 | Cluster B | ||||||
| Metal binding | 21 | 1 | Cluster B | ||||||
| Metal binding | 24 | 1 | Cluster B | ||||||
| Metal binding | 26 | 1 | Cluster B | ||||||
| Metal binding | 29 | 1 | Cluster B | ||||||
| Metal binding | 33 | 1 | Cluster A | ||||||
| Metal binding | 34 | 1 | Cluster A | ||||||
| Metal binding | 36 | 1 | Cluster A | ||||||
| Metal binding | 37 | 1 | Cluster A | ||||||
| Metal binding | 41 | 1 | Cluster A | ||||||
| Metal binding | 44 | 1 | Cluster A | ||||||
| Metal binding | 48 | 1 | Cluster A | ||||||
| Metal binding | 50 | 1 | Cluster A | ||||||
| Metal binding | 57 | 1 | Cluster A | ||||||
| Metal binding | 59 | 1 | Cluster A | ||||||
| Metal binding | 60 | 1 | Cluster A | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
| Modified residue | 51 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
References
| [1] | "Studies on the mechanism of early onset macular degeneration in cynomolgus monkeys. II. Suppression of metallothionein synthesis in the retina in oxidative stress." Nicolas M.G., Fujiki K., Murayama K., Suzuki M.T., Shindo N., Hotta Y., Iwata F., Fujimura T., Yoshikawa Y., Cho F., Kanai A. Exp. Eye Res. 62:399-408(1996) [PubMed: 8795458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Retina. |
Cross-references
3D structure databases | |
|---|---|
| SMR | P68303. Positions 1-61. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P68303. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT2_MACFA | ||||||||
| Accession | Primary (citable) accession number: P68303 Secondary accession number(s): P02796 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
