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Protein

Apolipoprotein A-I

Gene

APOA1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Gene namesi
Name:APOA1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000042532419 – 267Proapolipoprotein A-IAdd BLAST249
ChainiPRO_000000194225 – 267Apolipoprotein A-IAdd BLAST243
ChainiPRO_000041657425 – 266Truncated apolipoprotein A-IBy similarityAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110Methionine sulfoxideBy similarity1
Modified residuei136Methionine sulfoxideBy similarity1

Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.By similarity
Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP68292

Expressioni

Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons.

Interactioni

Subunit structurei

Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP68292
SMRiP68292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 891Add BLAST22
Repeati90 – 1112Add BLAST22
Repeati112 – 1223; half-lengthAdd BLAST11
Repeati123 – 1444Add BLAST22
Repeati145 – 1665Add BLAST22
Repeati167 – 1886Add BLAST22
Repeati189 – 2107Add BLAST22
Repeati211 – 2328Add BLAST22
Repeati233 – 2439; half-lengthAdd BLAST11
Repeati244 – 26710Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 26710 X approximate tandem repeatsAdd BLAST200

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00530000063081
HOVERGENiHBG105708
KOiK08757

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATVLTLAV LFLTGSQARH FWQQDEPPQT PWDRVKDLVT VYVEALKDSG
60 70 80 90 100
KDYVSQFEGS ALGKQLNLKL LDNWDSVTST VSKLREQLGP VTQEFWDNLE
110 120 130 140 150
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL
160 170 180 190 200
HEGTRQKLHE LHEKLSPLGE EVRDRARAHV DALRTHLAPY SDELRQRLAA
210 220 230 240 250
RLEALKENGG ARLAEYHAKA SEHLSTLSEK AKPALEDLRQ GLLPVLESFK
260
VSFLSALEEY TKKLSTQ
Length:267
Mass (Da):30,735
Last modified:October 25, 2004 - v1
Checksum:i869955C024088E21
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → P in AAA36834 (PubMed:3106152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15411 mRNA Translation: AAA36834.1
M83242 Genomic DNA Translation: AAA36832.1
M69223 Genomic DNA Translation: AAA36831.1
PIRiA26529
RefSeqiNP_001270674.1, NM_001283745.1
XP_015290827.1, XM_015435341.1
UniGeneiMfa.8179

Genome annotation databases

EnsembliENSMFAT00000011499; ENSMFAP00000037249; ENSMFAG00000037868
GeneIDi101925978
KEGGimcf:101925978

Similar proteinsi

Entry informationi

Entry nameiAPOA1_MACFA
AccessioniPrimary (citable) accession number: P68292
Secondary accession number(s): P15568, P17929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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