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Protein

Interleukin-2

Gene

IL2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001548821 – 154Interleukin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP68291

Expressioni

Gene expression databases

BgeeiENSMMUG00000021093

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000027764

Structurei

3D structure databases

ProteinModelPortaliP68291
SMRiP68291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOGENOMiHOG000048727
HOVERGENiHBG007496
InParanoidiP68291
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ
TreeFamiTF338200

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RDTKDLISNI NVIVLELKGS ETTLMCEYAD ETATIVEFLN RWITFCQSII

STLT
Length:154
Mass (Da):17,685
Last modified:October 25, 2004 - v1
Checksum:i6AEBA480F204BA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19847 mRNA Translation: AAB60400.1
RefSeqiNP_001040595.1, NM_001047130.1
UniGeneiMmu.3415

Genome annotation databases

EnsembliENSMMUT00000029666; ENSMMUP00000027764; ENSMMUG00000021093
GeneIDi708017
KEGGimcc:708017

Similar proteinsi

Entry informationi

Entry nameiIL2_MACMU
AccessioniPrimary (citable) accession number: P68291
Secondary accession number(s): P51498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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