Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucagon

Gene

GCG

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon
Gene namesi
Name:GCG
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000439191 – 29GlucagonAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.By similarity

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022730.

Structurei

3D structure databases

ProteinModelPortaliP68274.
SMRiP68274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Phylogenomic databases

eggNOGiENOG410IKZ8. Eukaryota.
ENOG4111VKC. LUCA.
HOGENOMiHOG000231876.
HOVERGENiHBG096041.
InParanoidiP68274.

Family and domain databases

InterProiView protein in InterPro
IPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
PANTHERiPTHR11418:SF1. PTHR11418:SF1. 1 hit.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
PRINTSiPR00275. GLUCAGON.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

P68274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT
Length:29
Mass (Da):3,483
Last modified:October 25, 2004 - v1
Checksum:i04C584D35C752B27
GO

Sequence databases

PIRiA91741.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLUC_RABIT
AccessioniPrimary (citable) accession number: P68274
Secondary accession number(s): P25449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 10, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families