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P68272 (MYC_FLV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Viral myc transforming protein

Short name=v-Myc
Gene names
Name:MYC
OrganismFeline leukemia virus
Taxonomic identifier11768 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes By similarity.

Subcellular location

Host nucleus Potential.

Miscellaneous

This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence AAA43059.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentHost nucleus
   DiseaseOncogene
   LigandDNA-binding
   Molecular functionActivator
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Viral myc transforming protein
PRO_0000127311

Regions

Domain354 – 40653bHLH
Region413 – 43422Leucine-zipper
Compositional bias33 – 375Poly-Gln
Compositional bias88 – 914Poly-Gly
Compositional bias253 – 2619Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
P68272 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 4B263D36F1A1F36E

FASTA43948,520
        10         20         30         40         50         60 
MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP 

        70         80         90        100        110        120 
LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD 

       130        140        150        160        170        180 
DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPSPARGPGG CPTSSLYLQD 

       190        200        210        220        230        240 
LTAAASECID PSVVFPYPLN DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPEPLAL 

       250        260        270        280        290        300 
HEETPPTTSS DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC 

       310        320        330        340        350        360 
HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT EENDKRRTHN 

       370        380        390        400        410        420 
VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAGE QKLISEKDLL 

       430 
RKRREQLKHK LEQLRNSCA 

« Hide

References

[1]"Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus."
Braun M.J., Deininger P.L., Casey J.W.
J. Virol. 55:177-183(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10973 Genomic DNA. Translation: AAA43059.1. Different initiation.

3D structure databases

ProteinModelPortalP68272.
SMRP68272. Positions 353-434.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFPIRSF001705. Myc_protein. 1 hit.
PRINTSPR00044. LEUZIPPRMYC.
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYC_FLV
AccessionPrimary (citable) accession number: P68272
Secondary accession number(s): P06877, P06878, Q28413
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 25, 2004
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families