P68272 (MYC_FLV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Viral myc transforming protein
Short name=v-Myc

Gene names

Name:

MYC

Organism

Feline leukemia virus

Taxonomic identifier

11768 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes By similarity.
Subcellular location	Host nucleus Potential.
Miscellaneous	This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.
Sequence caution	The sequence AAA43059.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of stress-activated MAPK cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB response to drug Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Viral myc transforming protein		PRO_0000127311
Regions
	Domain	368 – 407	40	Helix-loop-helix motif
	Domain	413 – 434	22	Leucine-zipper
	DNA binding	354 – 367	14	Basic motif
	Compositional bias	33 – 37	5	Poly-Gln
	Compositional bias	88 – 91	4	Poly-Gly
	Compositional bias	253 – 261	9	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P68272 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 4B263D36F1A1F36E	FASTA	439	48,520
	10 20 30 40 50 60 MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP 70 80 90 100 110 120 LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD 130 140 150 160 170 180 DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPSPARGPGG CPTSSLYLQD 190 200 210 220 230 240 LTAAASECID PSVVFPYPLN DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPEPLAL 250 260 270 280 290 300 HEETPPTTSS DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC 310 320 330 340 350 360 HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT EENDKRRTHN 370 380 390 400 410 420 VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAGE QKLISEKDLL 430 RKRREQLKHK LEQLRNSCA

References

[1]	"Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus." Braun M.J., Deininger P.L., Casey J.W. J. Virol. 55:177-183(1985) [PubMed: 2989554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10973 Genomic DNA. Translation: AAA43059.1. Different initiation.
3D structure databases
ProteinModelPortal	P68272.
SMR	P68272. Positions 353-434.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. IPR003327. Myc-LZ. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. PF02344. Myc-LZ. 1 hit. PF01056. Myc_N. 1 hit. [Graphical view]
PIRSF	PIRSF001705. Myc_protein. 1 hit.
PRINTS	PR00044. LEUZIPPRMYC.
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYC_FLV

Accession

Primary (citable) accession number: P68272
Secondary accession number(s): P06877, P06878, Q28413

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program