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P68272

- MYC_FLV

UniProt

P68272 - MYC_FLV

Protein

Viral myc transforming protein

Gene

MYC

Organism
Feline leukemia virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Viral myc transforming protein
    Short name:
    v-Myc
    Gene namesi
    Name:MYC
    OrganismiFeline leukemia virus
    Taxonomic identifieri11768 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiFelidae (cat family) [TaxID: 9681]

    Subcellular locationi

    Host nucleus Curated

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. nucleus Source: InterPro

    Keywords - Cellular componenti

    Host nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Viral myc transforming proteinPRO_0000127311Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP68272.
    SMRiP68272. Positions 353-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini354 – 40653bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni413 – 43422Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 375Poly-Gln
    Compositional biasi88 – 914Poly-Gly
    Compositional biasi253 – 2619Poly-Glu

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003327. Myc-LZ.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF02344. Myc-LZ. 1 hit.
    PF01056. Myc_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001705. Myc_protein. 1 hit.
    PRINTSiPR00044. LEUZIPPRMYC.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68272-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW    50
    KKFELLPTPP LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE 100
    MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA 150
    SYQAARKDSG SPSPARGPGG CPTSSLYLQD LTAAASECID PSVVFPYPLN 200
    DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPEPLAL HEETPPTTSS 250
    DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC 300
    HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT 350
    EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT 400
    AYILSVQAGE QKLISEKDLL RKRREQLKHK LEQLRNSCA 439
    Length:439
    Mass (Da):48,520
    Last modified:October 25, 2004 - v1
    Checksum:i4B263D36F1A1F36E
    GO

    Sequence cautioni

    The sequence AAA43059.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10973 Genomic DNA. Translation: AAA43059.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10973 Genomic DNA. Translation: AAA43059.1 . Different initiation.

    3D structure databases

    ProteinModelPortali P68272.
    SMRi P68272. Positions 353-434.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003327. Myc-LZ.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF02344. Myc-LZ. 1 hit.
    PF01056. Myc_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001705. Myc_protein. 1 hit.
    PRINTSi PR00044. LEUZIPPRMYC.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus."
      Braun M.J., Deininger P.L., Casey J.W.
      J. Virol. 55:177-183(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMYC_FLV
    AccessioniPrimary (citable) accession number: P68272
    Secondary accession number(s): P06877, P06878, Q28413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3