P68267 (GLHA_MACRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein hormones alpha chain

Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name=FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name=LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name=TSH-alpha
Thyrotropin alpha chain

Gene names

Name:

CGA

Organism

Macropus rufus (Red kangaroo) (Megaleia rufa)

Taxonomic identifier

9321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Diprotodontia › Macropodidae › Macropus

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the glycoprotein hormones subunit alpha family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 120	96	Glycoprotein hormones alpha chain		PRO_0000011643
Amino acid modifications
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 59		By similarity
	Disulfide bond	38 ↔ 88		By similarity
	Disulfide bond	56 ↔ 110		By similarity
	Disulfide bond	60 ↔ 112		By similarity
	Disulfide bond	87 ↔ 115		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P68267 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 837F323310E280CB	FASTA	120	13,513
	10 20 30 40 50 60 MDYYRKYAAV ILATLSVFLH ILHSFPDGEF IMQGCPECKL KENKYFSKLG APIYQCMGCC 70 80 90 100 110 120 FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG NAKVENHTEC HCSTCYYHKS

References

[1]	"cDNA cloning of luteinizing hormone subunits from brushtail possum and red kangaroo." Harrison G.A., Deane E.M., Cooper D.W. Mamm. Genome 9:638-642(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF017449 mRNA. Translation: AAC96020.1.
3D structure databases
ProteinModelPortal	P68267.
SMR	P68267. Positions 32-120.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000452.
Family and domain databases
InterPro	IPR000476. Glyco_hormone. [Graphical view]
PANTHER	PTHR11509. PTHR11509. 1 hit.
Pfam	PF00236. Hormone_6. 1 hit. [Graphical view]
PRINTS	PR00274. GLYCOHORMONE.
SMART	SM00067. GHA. 1 hit. [Graphical view]
PROSITE	PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit. PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit. PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLHA_MACRU

Accession

Primary (citable) accession number: P68267
Secondary accession number(s): O46687, O77752

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
Last sequence update:	October 25, 2004
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program