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P68255 (1433T_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
14-3-3 protein theta
Alternative name(s):
14-3-3 protein tau
Gene names
Name:Ywhaq
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 By similarity.

Subunit structure

Homodimer By similarity. Interacts with CDK16. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with SSH1 By similarity. Interacts with GAB2 By similarity. Interacts with the 'Ser-241' phosphorylated form of PDPK1 By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the 14-3-3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24524514-3-3 protein theta
PRO_0000058640

Sites

Site561Interaction with phosphoserine on interacting protein By similarity
Site1271Interaction with phosphoserine on interacting protein By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue31N6-acetyllysine By similarity
Modified residue491N6-acetyllysine By similarity
Modified residue681N6-acetyllysine By similarity
Modified residue1151N6-acetyllysine By similarity
Modified residue2321Phosphoserine; by CK1 Probable

Sequences

Sequence LengthMass (Da)Tools
P68255 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: E30471260E8B366E

FASTA24527,778
        10         20         30         40         50         60 
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR 

        70         80         90        100        110        120 
VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK 

       130        140        150        160        170        180 
MKGDYFRYLA EVACGDDRKQ TIENSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE 

       190        200        210        220        230        240 
ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA 


EGAEN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain."
Watanabe M., Isobe T., Ichimura T., Kuwano R., Takahashi Y., Kondo H., Inoue Y.
Brain Res. Mol. Brain Res. 25:113-121(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[3]Lubec G., Kang S.U., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 4-9; 12-18; 28-49; 61-68; 84-115; 128-157; 159-167 AND 194-222, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17614 mRNA. Translation: BAA04533.1.
BC062409 mRNA. Translation: AAH62409.1.
PIRS59927. I52647.
RefSeqNP_037185.1. NM_013053.1.
UniGeneRn.2502.

3D structure databases

ProteinModelPortalP68255.
SMRP68255. Positions 1-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247608. 3 interactions.
DIPDIP-947N.
IntActP68255. 4 interactions.
MINTMINT-203396.

PTM databases

PhosphoSiteP68255.

Proteomic databases

PaxDbP68255.
PRIDEP68255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011501; ENSRNOP00000011501; ENSRNOG00000008104.
GeneID25577.
KEGGrno:25577.

Organism-specific databases

CTD10971.
RGD3979. Ywhaq.

Phylogenomic databases

eggNOGCOG5040.
GeneTreeENSGT00730000110424.
HOGENOMHOG000240379.
HOVERGENHBG050423.
InParanoidP68255.
KOK16197.
OMACELRSIC.
OrthoDBEOG7HHWT3.
PhylomeDBP68255.
TreeFamTF102002.

Gene expression databases

GenevestigatorP68255.

Family and domain databases

Gene3D1.20.190.20. 1 hit.
InterProIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERPTHR18860. PTHR18860. 1 hit.
PfamPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFPIRSF000868. 14-3-3. 1 hit.
PRINTSPR00305. 1433ZETA.
SMARTSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMSSF48445. SSF48445. 1 hit.
PROSITEPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607215.
PROP68255.

Entry information

Entry name1433T_RAT
AccessionPrimary (citable) accession number: P68255
Secondary accession number(s): P35216
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families