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P68255

- 1433T_RAT

UniProt

P68255 - 1433T_RAT

Protein

14-3-3 protein theta

Gene

Ywhaq

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
    Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

    GO - Molecular functioni

    1. 14-3-3 protein binding Source: RGD
    2. protein binding Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    14-3-3 protein theta
    Alternative name(s):
    14-3-3 protein tau
    Gene namesi
    Name:Ywhaq
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi3979. Ywhaq.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. protein complex Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24524514-3-3 protein thetaPRO_0000058640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei3 – 31N6-acetyllysineBy similarity
    Modified residuei49 – 491N6-acetyllysineBy similarity
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei115 – 1151N6-acetyllysineBy similarity
    Modified residuei232 – 2321Phosphoserine; by CK1Curated

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP68255.
    PRIDEiP68255.

    PTM databases

    PhosphoSiteiP68255.

    Expressioni

    Gene expression databases

    GenevestigatoriP68255.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with CDK16. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with SSH1 By similarity. Interacts with GAB2 By similarity. Interacts with the 'Ser-241' phosphorylated form of PDPK1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi247608. 3 interactions.
    DIPiDIP-947N.
    IntActiP68255. 5 interactions.
    MINTiMINT-203396.

    Structurei

    3D structure databases

    ProteinModelPortaliP68255.
    SMRiP68255. Positions 1-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 14-3-3 family.Curated

    Phylogenomic databases

    eggNOGiCOG5040.
    GeneTreeiENSGT00730000110424.
    HOGENOMiHOG000240379.
    HOVERGENiHBG050423.
    InParanoidiP68255.
    KOiK16197.
    OMAiCELRSIC.
    OrthoDBiEOG7HHWT3.
    PhylomeDBiP68255.
    TreeFamiTF102002.

    Family and domain databases

    Gene3Di1.20.190.20. 1 hit.
    InterProiIPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view]
    PANTHERiPTHR18860. PTHR18860. 1 hit.
    PfamiPF00244. 14-3-3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000868. 14-3-3. 1 hit.
    PRINTSiPR00305. 1433ZETA.
    SMARTiSM00101. 14_3_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48445. SSF48445. 1 hit.
    PROSITEiPS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68255-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN    50
    VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL 100
    LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIENSQGAYQ 150
    EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI 200
    AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN 245
    Length:245
    Mass (Da):27,778
    Last modified:October 25, 2004 - v1
    Checksum:iE30471260E8B366E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17614 mRNA. Translation: BAA04533.1.
    BC062409 mRNA. Translation: AAH62409.1.
    PIRiI52647. S59927.
    RefSeqiNP_037185.1. NM_013053.1.
    UniGeneiRn.2502.

    Genome annotation databases

    EnsembliENSRNOT00000011501; ENSRNOP00000011501; ENSRNOG00000008104.
    GeneIDi25577.
    KEGGirno:25577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17614 mRNA. Translation: BAA04533.1 .
    BC062409 mRNA. Translation: AAH62409.1 .
    PIRi I52647. S59927.
    RefSeqi NP_037185.1. NM_013053.1.
    UniGenei Rn.2502.

    3D structure databases

    ProteinModelPortali P68255.
    SMRi P68255. Positions 1-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247608. 3 interactions.
    DIPi DIP-947N.
    IntActi P68255. 5 interactions.
    MINTi MINT-203396.

    PTM databases

    PhosphoSitei P68255.

    Proteomic databases

    PaxDbi P68255.
    PRIDEi P68255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011501 ; ENSRNOP00000011501 ; ENSRNOG00000008104 .
    GeneIDi 25577.
    KEGGi rno:25577.

    Organism-specific databases

    CTDi 10971.
    RGDi 3979. Ywhaq.

    Phylogenomic databases

    eggNOGi COG5040.
    GeneTreei ENSGT00730000110424.
    HOGENOMi HOG000240379.
    HOVERGENi HBG050423.
    InParanoidi P68255.
    KOi K16197.
    OMAi CELRSIC.
    OrthoDBi EOG7HHWT3.
    PhylomeDBi P68255.
    TreeFami TF102002.

    Miscellaneous databases

    NextBioi 607215.
    PROi P68255.

    Gene expression databases

    Genevestigatori P68255.

    Family and domain databases

    Gene3Di 1.20.190.20. 1 hit.
    InterProi IPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view ]
    PANTHERi PTHR18860. PTHR18860. 1 hit.
    Pfami PF00244. 14-3-3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000868. 14-3-3. 1 hit.
    PRINTSi PR00305. 1433ZETA.
    SMARTi SM00101. 14_3_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48445. SSF48445. 1 hit.
    PROSITEi PS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain."
      Watanabe M., Isobe T., Ichimura T., Kuwano R., Takahashi Y., Kondo H., Inoue Y.
      Brain Res. Mol. Brain Res. 25:113-121(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. Lubec G., Kang S.U., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 4-9; 12-18; 28-49; 61-68; 84-115; 128-157; 159-167 AND 194-222, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry namei1433T_RAT
    AccessioniPrimary (citable) accession number: P68255
    Secondary accession number(s): P35216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3