Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P68255

- 1433T_RAT

UniProt

P68255 - 1433T_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

14-3-3 protein theta

Gene

Ywhaq

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

GO - Molecular functioni

  1. 14-3-3 protein binding Source: RGD

GO - Biological processi

  1. protein targeting Source: Ensembl
  2. small GTPase mediated signal transduction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein theta
Alternative name(s):
14-3-3 protein tau
Gene namesi
Name:Ywhaq
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3979. Ywhaq.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24524514-3-3 protein thetaPRO_0000058640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei3 – 31N6-acetyllysineBy similarity
Modified residuei49 – 491N6-acetyllysineBy similarity
Modified residuei68 – 681N6-acetyllysineBy similarity
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei232 – 2321Phosphoserine; by CK1Curated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP68255.
PRIDEiP68255.

PTM databases

PhosphoSiteiP68255.

Expressioni

Gene expression databases

GenevestigatoriP68255.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with CDK16. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with SSH1 (By similarity). Interacts with GAB2 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247608. 4 interactions.
DIPiDIP-947N.
IntActiP68255. 5 interactions.
MINTiMINT-203396.

Structurei

3D structure databases

ProteinModelPortaliP68255.
SMRiP68255. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiCOG5040.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiP68255.
KOiK16197.
OMAiCELRSIC.
OrthoDBiEOG7HHWT3.
PhylomeDBiP68255.
TreeFamiTF102002.

Family and domain databases

Gene3Di1.20.190.20. 1 hit.
InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL
110 120 130 140 150
LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIENSQGAYQ
160 170 180 190 200
EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN
Length:245
Mass (Da):27,778
Last modified:October 25, 2004 - v1
Checksum:iE30471260E8B366E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17614 mRNA. Translation: BAA04533.1.
BC062409 mRNA. Translation: AAH62409.1.
PIRiI52647. S59927.
RefSeqiNP_037185.1. NM_013053.1.
UniGeneiRn.2502.

Genome annotation databases

EnsembliENSRNOT00000011501; ENSRNOP00000011501; ENSRNOG00000008104.
GeneIDi25577.
KEGGirno:25577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17614 mRNA. Translation: BAA04533.1 .
BC062409 mRNA. Translation: AAH62409.1 .
PIRi I52647. S59927.
RefSeqi NP_037185.1. NM_013053.1.
UniGenei Rn.2502.

3D structure databases

ProteinModelPortali P68255.
SMRi P68255. Positions 1-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247608. 4 interactions.
DIPi DIP-947N.
IntActi P68255. 5 interactions.
MINTi MINT-203396.

PTM databases

PhosphoSitei P68255.

Proteomic databases

PaxDbi P68255.
PRIDEi P68255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011501 ; ENSRNOP00000011501 ; ENSRNOG00000008104 .
GeneIDi 25577.
KEGGi rno:25577.

Organism-specific databases

CTDi 10971.
RGDi 3979. Ywhaq.

Phylogenomic databases

eggNOGi COG5040.
GeneTreei ENSGT00760000119116.
HOGENOMi HOG000240379.
HOVERGENi HBG050423.
InParanoidi P68255.
KOi K16197.
OMAi CELRSIC.
OrthoDBi EOG7HHWT3.
PhylomeDBi P68255.
TreeFami TF102002.

Miscellaneous databases

NextBioi 607215.
PROi P68255.

Gene expression databases

Genevestigatori P68255.

Family and domain databases

Gene3Di 1.20.190.20. 1 hit.
InterProi IPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view ]
PANTHERi PTHR18860. PTHR18860. 1 hit.
Pfami PF00244. 14-3-3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000868. 14-3-3. 1 hit.
PRINTSi PR00305. 1433ZETA.
SMARTi SM00101. 14_3_3. 1 hit.
[Graphical view ]
SUPFAMi SSF48445. SSF48445. 1 hit.
PROSITEi PS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain."
    Watanabe M., Isobe T., Ichimura T., Kuwano R., Takahashi Y., Kondo H., Inoue Y.
    Brain Res. Mol. Brain Res. 25:113-121(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Lubec G., Kang S.U., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 4-9; 12-18; 28-49; 61-68; 84-115; 128-157; 159-167 AND 194-222, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry namei1433T_RAT
AccessioniPrimary (citable) accession number: P68255
Secondary accession number(s): P35216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3