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Protein

Pancreatic hormone

Gene

PPY

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic hormone
Short name:
PH
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Gene namesi
Name:PPY
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Pancreatic hormonePRO_0000044805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Structurei

Secondary structure

1
36
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 3118Combined sources
Helixi32 – 354Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PPTX-ray1.37A1-36[»]
2BF9X-ray0.99A1-35[»]
2H3SNMR-A1-9[»]
B13-36[»]
2H3TNMR-A1-9[»]
B13-36[»]
2H4BNMR-A/B1-9[»]
C/D13-36[»]
ProteinModelPortaliP68249.
SMRiP68249. Positions 1-35.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68249.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

HOVERGENiHBG096194.
InParanoidiP68249.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GPSQPTYPGD DAPVEDLIRF YNDLQQYLNV VTRHRY
Length:36
Mass (Da):4,239
Last modified:October 25, 2004 - v1
Checksum:i67840E24949C9BCE
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PPTX-ray1.37A1-36[»]
2BF9X-ray0.99A1-35[»]
2H3SNMR-A1-9[»]
B13-36[»]
2H3TNMR-A1-9[»]
B13-36[»]
2H4BNMR-A/B1-9[»]
C/D13-36[»]
ProteinModelPortaliP68249.
SMRiP68249. Positions 1-35.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG096194.
InParanoidiP68249.

Miscellaneous databases

EvolutionaryTraceiP68249.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide."
    Wood S.P., Pitts J.E., Blundell T.L., Tickle I.J., Jenkins J.A.
    Eur. J. Biochem. 78:119-126(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CRYSTALLIZATION.
    Tissue: Pancreas.
  2. "X-ray analysis (1.4-A resolution) of avian pancreatic polypeptide. Small globular protein hormone."
    Blundell T.L., Pitts J.E., Tickle I.J., Wood S.P., Wu C.-W.
    Proc. Natl. Acad. Sci. U.S.A. 78:4175-4179(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
  3. "Conformational flexibility in a small globular hormone: X-ray analysis of avian pancreatic polypeptide at 0.98-A resolution."
    Glover I., Maneef I., Pitts J., Woods S.P., Moss D., Tickle I., Blundell T.L.
    Biopolymers 22:293-304(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.98 ANGSTROMS).

Entry informationi

Entry nameiPAHO_MELGA
AccessioniPrimary (citable) accession number: P68249
Secondary accession number(s): P01306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2004
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.