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Protein

Troponin I, fast skeletal muscle

Gene

TNNI2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 11612Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:TNNI2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 183182Troponin I, fast skeletal musclePRO_0000186147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP68246.
PRIDEiP68246.

Expressioni

Gene expression databases

BgeeiENSGALG00000006591.
ExpressionAtlasiP68246. baseline and differential.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

IntActiP68246. 1 interaction.
STRINGi9031.ENSGALP00000032067.

Structurei

Secondary structure

1
183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 4841Combined sources
Helixi58 – 9639Combined sources
Turni97 – 1048Combined sources
Helixi119 – 1279Combined sources
Helixi133 – 1419Combined sources
Beta strandi142 – 15312Combined sources
Helixi159 – 1679Combined sources
Helixi170 – 1789Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VDINMR-A132-183[»]
1VDJNMR-A132-183[»]
1YTZX-ray3.00I2-183[»]
1YV0X-ray7.00I2-138[»]
2W49electron microscopy35.002/5/8/Z4-144[»]
2W4Uelectron microscopy35.002/5/8/Z4-144[»]
ProteinModelPortaliP68246.
SMRiP68246. Positions 4-183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68246.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNCAdd
BLAST
Regioni97 – 11721Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP68246.
KOiK12043.
OrthoDBiEOG091G0NOD.
PhylomeDBiP68246.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEEKKRRA ATARRQHLKS AMLQLAVTEI EKEAAAKEVE KQNYLAEHCP
60 70 80 90 100
PLSLPGSMQE LQELCKKLHA KIDSVDEERY DTEVKLQKTN KELEDLSQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLRALLGSK HKVNMDLRAN LKQVKKEDTE
160 170 180
KEKDLRDVGD WRKNIEEKSG MEGRKKMFEA GES
Length:183
Mass (Da):21,234
Last modified:January 23, 2007 - v2
Checksum:iE33F7517E84BB09E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19926 mRNA. Translation: AAA61952.1.
X03832 mRNA. Translation: CAA27447.1.
PIRiA24918. TPCHIS.
RefSeqiNP_990748.1. NM_205417.1.
UniGeneiGga.5232.
Gga.700.

Genome annotation databases

GeneIDi396386.
KEGGigga:396386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19926 mRNA. Translation: AAA61952.1.
X03832 mRNA. Translation: CAA27447.1.
PIRiA24918. TPCHIS.
RefSeqiNP_990748.1. NM_205417.1.
UniGeneiGga.5232.
Gga.700.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VDINMR-A132-183[»]
1VDJNMR-A132-183[»]
1YTZX-ray3.00I2-183[»]
1YV0X-ray7.00I2-138[»]
2W49electron microscopy35.002/5/8/Z4-144[»]
2W4Uelectron microscopy35.002/5/8/Z4-144[»]
ProteinModelPortaliP68246.
SMRiP68246. Positions 4-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP68246. 1 interaction.
STRINGi9031.ENSGALP00000032067.

Proteomic databases

PaxDbiP68246.
PRIDEiP68246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396386.
KEGGigga:396386.

Organism-specific databases

CTDi7136.

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP68246.
KOiK12043.
OrthoDBiEOG091G0NOD.
PhylomeDBiP68246.

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP68246.
PROiP68246.

Gene expression databases

BgeeiENSGALG00000006591.
ExpressionAtlasiP68246. baseline and differential.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_CHICK
AccessioniPrimary (citable) accession number: P68246
Secondary accession number(s): P02644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.