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Protein

Hemoglobin subunit alpha-1/2

Gene
N/A
Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.By similarity

Miscellaneous

Adult sheep and other mammalian species produce unequal amounts of alpha-globin from their non-allelic loci.
The alpha-1 sequence is shown.
Sheep insoluble core region (positions 101-140) contains 1 more Gly, one more Glu, and two fewer Ser than the corresponding region shown (PubMed:6033754). According to PubMed:5658545 it contains one more Thr and one less Ser.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-1/2
Alternative name(s):
Alpha-1/2-globin
Hemoglobin alpha-1/2 chain
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000525842 – 142Hemoglobin subunit alpha-1/2Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.By similarity

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi54 – 72Combined sources19
Helixi74 – 76Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi97 – 113Combined sources17
Helixi115 – 117Combined sources3
Helixi120 – 137Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QU0X-ray2.70A/C2-142[»]
ProteinModelPortaliP68240
SMRiP68240
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68240

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKSN VKAAWGKVGG NAGAYGAEAL ERMFLSFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKGHG EKVAAALTKA VGHLDDLPGT LSDLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHSLLVTL ACHLPNDFTP AVHASLDKFL ANVSTVLTSK YR
Length:142
Mass (Da):15,164
Last modified:January 23, 2007 - v2
Checksum:i1C3CF84DEB3C2176
GO

Polymorphismi

Different alleles are known. The alpha-A allelic variant contains Gly-16.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti16G → D in allele alpha-D. 1 Publication1
Natural varianti20G → S in alpha-2. 1
Natural varianti76D → Y in alpha-1-B. 1
Natural varianti114L → H in alpha-2. 1
Natural varianti116N → S in alpha-2. 1

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBA_SHEEP
AccessioniPrimary (citable) accession number: P68240
Secondary accession number(s): P01970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health