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P68174

- STSY_RAUMA

UniProt

P68174 - STSY_RAUMA

Protein

Strictosidine synthase

Gene

STR1

Organism
Rauvolfia mannii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

    Catalytic activityi

    3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

    Pathwayi

    GO - Molecular functioni

    1. strictosidine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. alkaloid metabolic process Source: UniProtKB-KW
    2. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Alkaloid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00311; UER00447.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Strictosidine synthase (EC:4.3.3.2)
    Gene namesi
    Name:STR1
    OrganismiRauvolfia mannii
    Taxonomic identifieri4062 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeRauvolfiinaeRauvolfia

    Subcellular locationi

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 20›20By similarityAdd
    BLAST
    Chaini21 – 342322Strictosidine synthasePRO_0000033333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP68174.
    SMRiP68174. Positions 27-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the strictosidine synthase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view]
    PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
    PfamiPF03088. Str_synth. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P68174-1 [UniParc]FASTAAdd to Basket

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    KLSDSQTMAL FTVFLLFLSS SLALSSPILK EILIEAPSYA PNSFTFDSTN    50
    KGFYTSVQDG RVIKYEGPNS GFVDFAYASP YWNKAFCENS TDAEKRPLCG 100
    RTYDISYNLQ NNQLYIVDCY YHLSVVGSEG GHATQLATSV DGVPFKWLYA 150
    VTVDQRTGIV YFTDVSTLYD DRGVQQIMDT SDKTGRLIKY DPSTKETTLL 200
    LKELHVPGGA EVSADSSFVL VAEFLSHQIV KYWLEGPKKG TAEVLVKIPN 250
    PGNIKRNADG HFWVSSSEEL DGNMHGRVDP KGIKFDEFGN ILEVIPLPPP 300
    FAGEHFEQIQ EHDGLLYIGT LFHGSVGILV YDKKGNSFVS SH 342
    Length:342
    Mass (Da):37,960
    Last modified:October 25, 2004 - v1
    Checksum:i61F4B51826E269E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63431 Genomic DNA. Translation: CAA45025.1.
    PIRiS29894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63431 Genomic DNA. Translation: CAA45025.1 .
    PIRi S29894.

    3D structure databases

    ProteinModelPortali P68174.
    SMRi P68174. Positions 27-331.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00311 ; UER00447 .

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view ]
    PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
    Pfami PF03088. Str_synth. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Strictosidine synthase from Rauvolfia serpentina: analysis of a gene involved in indole alkaloid biosynthesis."
      Bracher D., Kutchan T.M.
      Arch. Biochem. Biophys. 294:717-723(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSTSY_RAUMA
    AccessioniPrimary (citable) accession number: P68174
    Secondary accession number(s): P15324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3