Actin, alpha skeletal muscle - Bos taurus (Bovine)

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Reviewed, UniProtKB/Swiss-Prot P68138 (ACTS_BOVIN)

Last modified November 24, 2009. Version 53. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Actin, alpha skeletal muscle
Alternative name(s):
Alpha-actin-1

Gene names

Name:	ACTA1
Synonyms:	ACTA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID By similarity.
Subcellular location	Cytoplasm › cytoskeleton.
Miscellaneous	In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities	Belongs to the actin family.

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Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Muscle protein
PTM	Acetylation Methylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	muscle thin filament assembly Inferred from sequence or structural similarity. Source: UniProtKB skeletal muscle fiber development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	actin filament Inferred from sequence or structural similarity. Source: UniProtKB stress fiber Inferred from sequence or structural similarity. Source: UniProtKB striated muscle thin filament Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Propeptide

1 – 2

Removed in mature form

PRO_0000000842

Chain

3 – 377

375

Actin, alpha skeletal muscle

PRO_0000000843

Amino acid modifications

Modified residue

N-acetylaspartate

Modified residue

Phosphotyrosine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

Tele-methylhistidine

Modified residue

Phosphotyrosine By similarity

Modified residue

193

N6-acetyllysine By similarity

Modified residue

242

Phosphotyrosine By similarity

Modified residue

328

N6-acetyllysine By similarity

Modified residue

330

N6-acetyllysine By similarity

Experimental info

Sequence conflict

349

A → R in AAA82873. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P68138-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: DF2A3A046346A179
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FASTA

377

42,051

        10         20         30         40         50         60 
MCDEDETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA 

        70         80         90        100        110        120 
QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK 

       130        140        150        160        170        180 
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 

       190        200        210        220        230        240 
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 

       250        260        270        280        290        300 
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 

       310        320        330        340        350        360 
MSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIT 

       370 
KQEYDEAGPS IVHRKCF

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence, structure, and preliminary studies on the transcriptional regulation of the bovine alpha skeletal actin gene." Davey H.W., Kelly J.K., Wildeman A.G. DNA Cell Biol. 14:609-618(1995) [PubMed: 7626220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.
[3]	"The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation." Vandekerckhove J., Weber K. Differentiation 14:123-133(1979) [PubMed: 499690] [Abstract] Cited for: PROTEIN SEQUENCE OF 3-377.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U02285 Genomic DNA. Translation: AAA82873.1. BC102376 mRNA. Translation: AAI02377.1.
IPI	IPI00697648.
RefSeq	NP_776650.1.
UniGene	Bt.88733
3D structure databases
SMR	P68138. Positions 6-373.
ModBase	Search...
Protein-protein interaction databases
STRING	P68138.
Genome annotation databases
Ensembl	ENSBTAT00000006534; ENSBTAP00000006534; ENSBTAG00000004965; Bos taurus. [Genome view]
GeneID	281592.
KEGG	bta:281592.
Organism-specific databases
CTD	281592.
Phylogenomic databases
HOVERGEN	P68138.
OMA	FVGMESA
Family and domain databases
InterPro	IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ACTS_BOVIN

Accession

Primary (citable) accession number: P68138
Secondary accession number(s): P02568, P99020, Q3ZCG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents