P68107 (FKB1B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1B
Short name=PPIase FKBP1B
EC=5.2.1.8

Alternative name(s):
12.6 kDa FK506-binding protein
Short name=12.6 kDa FKBP
Short name=FKBP-12.6
FK506-binding protein 1B
Short name=FKBP-1B
Immunophilin FKBP12.6
Rotamase

Gene names

Name:	FKBP1B
Synonyms:	FKBP12.6

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. Ref.2
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subunit structure	Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2 By similarity.
Subcellular location	Cytoplasm. Sarcoplasmic reticulum By similarity Ref.2.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.
Mass spectrometry	Molecular mass is 11652 Da from positions 2 - 108. Ref.2

Ontologies

Keywords
Cellular component	Cytoplasm Sarcoplasmic reticulum
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell proliferation Inferred from electronic annotation. Source: Compara insulin secretion Inferred from electronic annotation. Source: Compara negative regulation of heart rate Inferred from electronic annotation. Source: Compara negative regulation of insulin secretion involved in cellular response to glucose stimulus Inferred from electronic annotation. Source: Compara negative regulation of protein phosphatase type 2B activity Inferred from sequence or structural similarity. Source: RefGenome neuronal action potential propagation Inferred from electronic annotation. Source: Compara protein folding Inferred from electronic annotation. Source: UniProtKB-KW regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Inferred from electronic annotation. Source: Compara regulation of ryanodine-sensitive calcium-release channel activity Inferred from sequence or structural similarity. Source: RefGenome release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from electronic annotation. Source: Compara response to redox state Inferred from electronic annotation. Source: Compara smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	calcium channel complex Inferred from sequence or structural similarity. Source: RefGenome sarcoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: RefGenome
Molecular_function	FK506 binding Inferred from sequence or structural similarity. Source: RefGenome peptidyl-prolyl cis-trans isomerase activity Inferred from sequence or structural similarity. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 108	107	Peptidyl-prolyl cis-trans isomerase FKBP1B		PRO_0000075294
Regions
	Domain	20 – 108	89	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	P68107 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: BAC2A25945F63AC4	FASTA	108	11,783
	10 20 30 40 50 60 MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF 70 80 90 100 EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.
[2]	"Inhibition of calcineurin by a novel FK-506-binding protein." Sewell T.J., Lam E., Martin M.M., Leszyk J., Weidner J., Calaycay J., Griffin P., Williams H., Hung S., Cryan J., Sigal N.H., Wiederrecht G.J. J. Biol. Chem. 269:21094-21102(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-108, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC140549 mRNA. Translation: AAI40550.1.
IPI	IPI00705270.
PIR	A53924.
RefSeq	NP_001091627.1. NM_001098158.1.
UniGene	Bt.76948.
3D structure databases
ProteinModelPortal	P68107.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000004419; ENSBTAP00000004419; ENSBTAG00000003409.
GeneID	785179.
KEGG	bta:785179.
Organism-specific databases
CTD	2281.
Phylogenomic databases
eggNOG	COG0545.
GeneTree	ENSGT00550000074272.
HOGENOM	HOG000154887.
HOVERGEN	HBG051623.
InParanoid	P68107.
KO	K09568.
OMA	TIGRNEV.
OrthoDB	EOG42NJ1X.
Family and domain databases
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
PANTHER	PTHR10516. PTHR10516. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P68107.
NextBio	20927141.

Entry information

Entry name

FKB1B_BOVIN

Accession

Primary (citable) accession number: P68107
Secondary accession number(s): A5D7G8 , Q13664, Q16645, Q9BQ40

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program