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P68106 (FKB1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1B
Short name=PPIase FKBP1B
EC=5.2.1.8
Alternative name(s):
12.6 kDa FK506-binding protein
Short name=12.6 kDa FKBP
Short name=FKBP-12.6
FK506-binding protein 1B
Short name=FKBP-1B
Immunophilin FKBP12.6
Rotamase
h-FKBP-12
Gene names
Name:FKBP1B
Synonyms:FKBP12.6, FKBP1L, FKBP9, OTK4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Isoform 1 and isoform 2 are Ubiquitous with highest levels in brain and thymus.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP1 subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   Molecular functionIsomerase
Rotamase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological process'de novo' protein folding

Traceable author statement. Source: BHF-UCL

negative regulation of heart rate

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of protein phosphatase type 2B activity

Inferred from direct assay Ref.2. Source: BHF-UCL

protein maturation by protein folding

Traceable author statement. Source: BHF-UCL

protein refolding

Traceable author statement. Source: BHF-UCL

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of ryanodine-sensitive calcium-release channel activity

Inferred from mutant phenotype Ref.2. Source: BHF-UCL

response to redox state

Inferred from direct assay. Source: BHF-UCL

   Cellular componentcalcium channel complex

Inferred from direct assay. Source: BHF-UCL

cytosol

Inferred by curator Ref.2. Source: BHF-UCL

sarcoplasmic reticulum membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular functionFK506 binding

Inferred from direct assay Ref.2. Source: BHF-UCL

peptidyl-prolyl cis-trans isomerase activity

Inferred from direct assay Ref.1Ref.2. Source: BHF-UCL

receptor binding

Inferred from physical interaction. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P68106-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P68106-2)

The sequence of this isoform differs from the canonical sequence as follows:
     67-108: MSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE → LGPLSPLPICPHPC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 108107Peptidyl-prolyl cis-trans isomerase FKBP1B
PRO_0000075295

Regions

Domain20 – 10889PPIase FKBP-type

Natural variations

Alternative sequence67 – 10842MSLGQ…LLNLE → LGPLSPLPICPHPC in isoform 2.
VSP_005184

Secondary structure

1 .................... 108
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BAC2A25945F63AC4

FASTA10811,783
        10         20         30         40         50         60 
MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF 

        70         80         90        100 
EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

« Hide

Isoform 2 [UniParc] [UniParc].

Checksum: 99C0A9C743984BA2
Show »

FASTA808,802

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts."
Arakawa H., Nagase H., Hayashi N., Fujiwara T., Ogawa M., Shin S., Nakamura Y.
Biochem. Biophys. Res. Commun. 200:836-843(1994) [PubMed: 7513996] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Fetal brain.
[2]"A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor."
Lam E., Martin M.M., Timerman A.P., Sabers C., Fleischer S., Lukas T., Abraham R.T., O'Keefe S.J., O'Neill E.A., Wiederrecht G.J.
J. Biol. Chem. 270:26511-26522(1995) [PubMed: 7592869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain and Heart muscle.
[3]"FKBP9: an alternative splice variant of the FK506-binding protein FKBP12.6 expressed in the human heart."
Seidler T., Kussebi N., Prestle J.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6."
Nakazawa T., Takasawa S., Noguchi N., Nata K., Tohgo A., Mori M., Nakagawara K., Akiyama T., Ikeda T., Yamauchi A., Takahashi I., Yoshikawa T., Okamoto H.
Gene 360:55-64(2005) [PubMed: 16122887] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[8]"Structure of FKBP12.6 in complex with rapamycin."
Deivanayagam C.C., Carson M., Thotakura A., Narayana S.V., Chodavarapu R.S.
Acta Crystallogr. D 56:266-271(2000) [PubMed: 10713512] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S69815 mRNA. Translation: AAB30684.1.
D38037 mRNA. Translation: BAA07232.1.
L37086 mRNA. Translation: AAC37581.1.
S69800 mRNA. Translation: AAB30685.1.
AF322070 mRNA. Translation: AAK11191.1.
AB190793 Genomic DNA. Translation: BAE44300.1.
AC008073 Genomic DNA. Translation: AAY14663.1.
CH471053 Genomic DNA. Translation: EAX00769.1.
BC002614 mRNA. Translation: AAH02614.1.
IPIIPI00073704.
IPI00396151.
PIRJC2188.
RefSeqNP_004107.1. NM_004116.3.
NP_473374.1. NM_054033.2.
UniGeneHs.709461.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1C9HX-ray2.00A2-108[»]
ProteinModelPortalP68106.
SMRP68106. Positions 2-108.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48796N.
STRINGP68106.

Polymorphism databases

DMDM61224185.

Proteomic databases

PRIDEP68106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380986; ENSP00000370373; ENSG00000119782.
GeneID2281.
KEGGhsa:2281.
UCSCuc002rer.1. human.
uc002res.1. human.

Organism-specific databases

CTD2281.
GeneCardsGC02P024272.
HGNCHGNC:3712. FKBP1B.
MIM600620. gene.
neXtProtNX_P68106.
PharmGKBPA28154.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20054.
GeneTreeENSGT00550000074272.
HOGENOMHBG731200.
HOVERGENHBG051623.
InParanoidP68106.
OMADMAYGAT.
PhylomeDBP68106.

Gene expression databases

BgeeP68106.
CleanExHS_FKBP1B.
HS_FKBP9.
GenevestigatorP68106.
GermOnlineENSG00000119782. Homo sapiens.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
KOK09568.
PANTHERPTHR10516. PPIase_FKBP. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio9275.
SOURCESearch...

Entry information

Entry nameFKB1B_HUMAN
AccessionPrimary (citable) accession number: P68106
Secondary accession number(s): Q13664 expand/collapse secondary AC list , Q16645, Q53TM2, Q9BQ40
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents