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Protein

Myoglobin

Gene

MB

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme distal ligand)
Metal bindingi94 – 941Iron (heme proximal ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP68082.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 154153MyoglobinPRO_0000053302Add
BLAST

Proteomic databases

PRIDEiP68082.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015509.

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915Combined sources
Helixi22 – 3615Combined sources
Helixi38 – 414Combined sources
Helixi45 – 473Combined sources
Helixi53 – 586Combined sources
Helixi60 – 9637Combined sources
Helixi102 – 11918Combined sources
Turni121 – 1233Combined sources
Helixi126 – 14924Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZIX-ray2.00A2-154[»]
1BJEX-ray1.80A2-154[»]
1DWRX-ray1.45A2-154[»]
1DWSX-ray1.45A2-154[»]
1DWTX-ray1.40A2-154[»]
1GJNX-ray1.35A2-154[»]
1HRMX-ray1.70A2-154[»]
1HSYX-ray1.90A2-154[»]
1NPFX-ray1.90A2-154[»]
1NPGX-ray1.70A2-154[»]
1NZ2X-ray1.90A2-154[»]
1NZ3X-ray1.60A2-154[»]
1NZ4X-ray1.80A2-154[»]
1NZ5X-ray1.70A2-154[»]
1RSEX-ray1.70A2-154[»]
1WLAX-ray1.70A2-154[»]
1XCHX-ray1.70A2-154[»]
1YMAX-ray2.00A2-154[»]
1YMBX-ray1.90A2-154[»]
1YMCX-ray2.00A2-154[»]
2FRFX-ray1.20A2-154[»]
2FRIX-ray1.60X2-154[»]
2FRJX-ray1.30X2-154[»]
2FRKX-ray1.30X2-154[»]
2IN4X-ray2.15A2-154[»]
2NSRX-ray1.90A2-154[»]
2NSSX-ray2.00A2-154[»]
2O58X-ray1.65X2-154[»]
2O5BX-ray2.00X2-154[»]
2O5LX-ray1.70X2-154[»]
2O5MX-ray1.65X2-154[»]
2O5OX-ray1.60X2-154[»]
2O5QX-ray1.90X2-154[»]
2O5SX-ray1.60X2-154[»]
2O5TX-ray1.60X2-154[»]
2V1EX-ray1.30A2-154[»]
2V1FX-ray1.20A2-154[»]
2V1GX-ray1.35A2-154[»]
2V1HX-ray1.30A2-154[»]
2V1IX-ray1.20A2-154[»]
2V1JX-ray1.40A2-154[»]
2V1KX-ray1.25A2-154[»]
2VLXX-ray1.30A2-154[»]
2VLYX-ray1.60A2-154[»]
2VLZX-ray1.50A2-154[»]
2VM0X-ray1.60A2-154[»]
3BA2X-ray1.80A2-154[»]
3HC9X-ray2.00A2-154[»]
3HENX-ray1.90A2-154[»]
3HEOX-ray2.00A2-154[»]
3HEPX-ray1.95A2-154[»]
3LR7X-ray1.60A2-154[»]
3LR9X-ray1.55A2-154[»]
3RJ6X-ray1.23A/B2-154[»]
3RJNX-ray1.90B2-154[»]
3V2VX-ray1.65A2-154[»]
3V2ZX-ray1.65A2-154[»]
3VAUX-ray1.70A2-154[»]
3VM9X-ray1.05A/B2-154[»]
3WFTX-ray1.30A2-154[»]
3WFUX-ray1.35A2-154[»]
3WI8X-ray2.20A2-154[»]
3WYOX-ray2.00A/B/C/D2-154[»]
4DC7X-ray1.50A2-153[»]
4DC8X-ray1.50A2-153[»]
4NS2X-ray1.18A1-154[»]
ProteinModelPortaliP68082.
SMRiP68082. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68082.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276460.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP68082.
OMAiTKHKIPI.
OrthoDBiEOG7KSX9V.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQQ VLNVWGKVEA DIAGHGQEVL IRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGTVVL TALGGILKKK GHHEAELKPL AQSHATKHKI
110 120 130 140 150
PIKYLEFISD AIIHVLHSKH PGDFGADAQG AMTKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,083
Last modified:January 23, 2007 - v2
Checksum:i20EABC4A66ACE975
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231D → N AA sequence (PubMed:4902609).Curated

Sequence databases

PIRiA91098. MYHO.
RefSeqiNP_001157488.1. NM_001164016.1.
UniGeneiEca.16922.

Genome annotation databases

EnsembliENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
GeneIDi100054434.
KEGGiecb:100054434.

Cross-referencesi

Sequence databases

PIRiA91098. MYHO.
RefSeqiNP_001157488.1. NM_001164016.1.
UniGeneiEca.16922.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZIX-ray2.00A2-154[»]
1BJEX-ray1.80A2-154[»]
1DWRX-ray1.45A2-154[»]
1DWSX-ray1.45A2-154[»]
1DWTX-ray1.40A2-154[»]
1GJNX-ray1.35A2-154[»]
1HRMX-ray1.70A2-154[»]
1HSYX-ray1.90A2-154[»]
1NPFX-ray1.90A2-154[»]
1NPGX-ray1.70A2-154[»]
1NZ2X-ray1.90A2-154[»]
1NZ3X-ray1.60A2-154[»]
1NZ4X-ray1.80A2-154[»]
1NZ5X-ray1.70A2-154[»]
1RSEX-ray1.70A2-154[»]
1WLAX-ray1.70A2-154[»]
1XCHX-ray1.70A2-154[»]
1YMAX-ray2.00A2-154[»]
1YMBX-ray1.90A2-154[»]
1YMCX-ray2.00A2-154[»]
2FRFX-ray1.20A2-154[»]
2FRIX-ray1.60X2-154[»]
2FRJX-ray1.30X2-154[»]
2FRKX-ray1.30X2-154[»]
2IN4X-ray2.15A2-154[»]
2NSRX-ray1.90A2-154[»]
2NSSX-ray2.00A2-154[»]
2O58X-ray1.65X2-154[»]
2O5BX-ray2.00X2-154[»]
2O5LX-ray1.70X2-154[»]
2O5MX-ray1.65X2-154[»]
2O5OX-ray1.60X2-154[»]
2O5QX-ray1.90X2-154[»]
2O5SX-ray1.60X2-154[»]
2O5TX-ray1.60X2-154[»]
2V1EX-ray1.30A2-154[»]
2V1FX-ray1.20A2-154[»]
2V1GX-ray1.35A2-154[»]
2V1HX-ray1.30A2-154[»]
2V1IX-ray1.20A2-154[»]
2V1JX-ray1.40A2-154[»]
2V1KX-ray1.25A2-154[»]
2VLXX-ray1.30A2-154[»]
2VLYX-ray1.60A2-154[»]
2VLZX-ray1.50A2-154[»]
2VM0X-ray1.60A2-154[»]
3BA2X-ray1.80A2-154[»]
3HC9X-ray2.00A2-154[»]
3HENX-ray1.90A2-154[»]
3HEOX-ray2.00A2-154[»]
3HEPX-ray1.95A2-154[»]
3LR7X-ray1.60A2-154[»]
3LR9X-ray1.55A2-154[»]
3RJ6X-ray1.23A/B2-154[»]
3RJNX-ray1.90B2-154[»]
3V2VX-ray1.65A2-154[»]
3V2ZX-ray1.65A2-154[»]
3VAUX-ray1.70A2-154[»]
3VM9X-ray1.05A/B2-154[»]
3WFTX-ray1.30A2-154[»]
3WFUX-ray1.35A2-154[»]
3WI8X-ray2.20A2-154[»]
3WYOX-ray2.00A/B/C/D2-154[»]
4DC7X-ray1.50A2-153[»]
4DC8X-ray1.50A2-153[»]
4NS2X-ray1.18A1-154[»]
ProteinModelPortaliP68082.
SMRiP68082. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015509.

Proteomic databases

PRIDEiP68082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
GeneIDi100054434.
KEGGiecb:100054434.

Organism-specific databases

CTDi4151.

Phylogenomic databases

eggNOGiNOG276460.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP68082.
OMAiTKHKIPI.
OrthoDBiEOG7KSX9V.
TreeFamiTF332967.

Enzyme and pathway databases

SABIO-RKP68082.

Miscellaneous databases

EvolutionaryTraceiP68082.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Heart muscle.
  2. "Residue 122 of sperm whale and horse myoglobin."
    Romero-Herrera A.E., Lehmann H.
    Biochim. Biophys. Acta 336:318-323(1974)
    Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Skeletal muscle.
  3. "Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels."
    Jahnen W., Ward L.D., Reid G.E., Moritz R.L., Simpson R.J.
    Biochem. Biophys. Res. Commun. 166:139-145(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16 AND 57-71.
  4. "High-resolution study of the three-dimensional structure of horse heart metmyoglobin."
    Evans S.V., Brayer G.D.
    J. Mol. Biol. 213:885-897(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  5. "Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination."
    Evans S.V., Brayer G.D.
    J. Biol. Chem. 263:4263-4268(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. "Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants."
    Bogumil R., Maurus R., Hildebrand D.P., Brayer G.D., Mauk A.G.
    Biochemistry 34:10483-10490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT THR-65.
  7. "Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin."
    Chu K., Vojtchovsky J., McMahon B.H., Sweet R.M., Berendzen J., Schlichting I.
    Nature 403:921-923(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

Entry informationi

Entry nameiMYG_HORSE
AccessioniPrimary (citable) accession number: P68082
Secondary accession number(s): P02188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.