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P68082

- MYG_HORSE

UniProt

P68082 - MYG_HORSE

Protein

Myoglobin

Gene

MB

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Iron (heme distal ligand)
    Metal bindingi94 – 941Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. brown fat cell differentiation Source: Ensembl
    2. enucleate erythrocyte differentiation Source: Ensembl
    3. heart development Source: Ensembl
    4. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP68082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myoglobin
    Gene namesi
    Name:MB
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 28

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 154153MyoglobinPRO_0000053302Add
    BLAST

    Proteomic databases

    PRIDEiP68082.

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1915
    Helixi22 – 3615
    Helixi38 – 414
    Helixi45 – 473
    Helixi53 – 586
    Helixi60 – 9637
    Helixi102 – 11918
    Turni121 – 1233
    Helixi126 – 14924

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AZIX-ray2.00A2-154[»]
    1BJEX-ray1.80A2-154[»]
    1DWRX-ray1.45A2-154[»]
    1DWSX-ray1.45A2-154[»]
    1DWTX-ray1.40A2-154[»]
    1GJNX-ray1.35A2-154[»]
    1HRMX-ray1.70A2-154[»]
    1HSYX-ray1.90A2-154[»]
    1NPFX-ray1.90A2-154[»]
    1NPGX-ray1.70A2-154[»]
    1NZ2X-ray1.90A2-154[»]
    1NZ3X-ray1.60A2-154[»]
    1NZ4X-ray1.80A2-154[»]
    1NZ5X-ray1.70A2-154[»]
    1RSEX-ray1.70A2-154[»]
    1WLAX-ray1.70A2-154[»]
    1XCHX-ray1.70A2-154[»]
    1YMAX-ray2.00A2-154[»]
    1YMBX-ray1.90A2-154[»]
    1YMCX-ray2.00A2-154[»]
    2FRFX-ray1.20A2-154[»]
    2FRIX-ray1.60X2-154[»]
    2FRJX-ray1.30X2-154[»]
    2FRKX-ray1.30X2-154[»]
    2IN4X-ray2.15A2-154[»]
    2NSRX-ray1.90A2-154[»]
    2NSSX-ray2.00A2-154[»]
    2O58X-ray1.65X2-154[»]
    2O5BX-ray2.00X2-154[»]
    2O5LX-ray1.70X2-154[»]
    2O5MX-ray1.65X2-154[»]
    2O5OX-ray1.60X2-154[»]
    2O5QX-ray1.90X2-154[»]
    2O5SX-ray1.60X2-154[»]
    2O5TX-ray1.60X2-154[»]
    2V1EX-ray1.30A2-154[»]
    2V1FX-ray1.20A2-154[»]
    2V1GX-ray1.35A2-154[»]
    2V1HX-ray1.30A2-154[»]
    2V1IX-ray1.20A2-154[»]
    2V1JX-ray1.40A2-154[»]
    2V1KX-ray1.25A2-154[»]
    2VLXX-ray1.30A2-154[»]
    2VLYX-ray1.60A2-154[»]
    2VLZX-ray1.50A2-154[»]
    2VM0X-ray1.60A2-154[»]
    3BA2X-ray1.80A2-154[»]
    3HC9X-ray2.00A2-154[»]
    3HENX-ray1.90A2-154[»]
    3HEOX-ray2.00A2-154[»]
    3HEPX-ray1.95A2-154[»]
    3LR7X-ray1.60A2-154[»]
    3LR9X-ray1.55A2-154[»]
    3RJ6X-ray1.23A/B2-154[»]
    3RJNX-ray1.90B2-154[»]
    3V2VX-ray1.65A2-154[»]
    3V2ZX-ray1.65A2-154[»]
    3VAUX-ray1.70A2-154[»]
    3VM9X-ray1.05A/B2-154[»]
    3WI8X-ray2.20A2-154[»]
    4DC7X-ray1.50A2-153[»]
    4DC8X-ray1.50A2-153[»]
    ProteinModelPortaliP68082.
    SMRiP68082. Positions 2-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP68082.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276460.
    GeneTreeiENSGT00730000110844.
    HOGENOMiHOG000070111.
    HOVERGENiHBG107340.
    InParanoidiP68082.
    OMAiDAQGAMN.
    OrthoDBiEOG7KSX9V.
    TreeFamiTF332967.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view]
    PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00613. MYOGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P68082-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSDGEWQQ VLNVWGKVEA DIAGHGQEVL IRLFTGHPET LEKFDKFKHL    50
    KTEAEMKASE DLKKHGTVVL TALGGILKKK GHHEAELKPL AQSHATKHKI 100
    PIKYLEFISD AIIHVLHSKH PGDFGADAQG AMTKALELFR NDIAAKYKEL 150
    GFQG 154
    Length:154
    Mass (Da):17,083
    Last modified:January 23, 2007 - v2
    Checksum:i20EABC4A66ACE975
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231D → N AA sequence (PubMed:4902609)Curated

    Sequence databases

    PIRiA91098. MYHO.
    RefSeqiNP_001157488.1. NM_001164016.1.
    UniGeneiEca.16922.

    Genome annotation databases

    EnsembliENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
    GeneIDi100054434.
    KEGGiecb:100054434.

    Cross-referencesi

    Sequence databases

    PIRi A91098. MYHO.
    RefSeqi NP_001157488.1. NM_001164016.1.
    UniGenei Eca.16922.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AZI X-ray 2.00 A 2-154 [» ]
    1BJE X-ray 1.80 A 2-154 [» ]
    1DWR X-ray 1.45 A 2-154 [» ]
    1DWS X-ray 1.45 A 2-154 [» ]
    1DWT X-ray 1.40 A 2-154 [» ]
    1GJN X-ray 1.35 A 2-154 [» ]
    1HRM X-ray 1.70 A 2-154 [» ]
    1HSY X-ray 1.90 A 2-154 [» ]
    1NPF X-ray 1.90 A 2-154 [» ]
    1NPG X-ray 1.70 A 2-154 [» ]
    1NZ2 X-ray 1.90 A 2-154 [» ]
    1NZ3 X-ray 1.60 A 2-154 [» ]
    1NZ4 X-ray 1.80 A 2-154 [» ]
    1NZ5 X-ray 1.70 A 2-154 [» ]
    1RSE X-ray 1.70 A 2-154 [» ]
    1WLA X-ray 1.70 A 2-154 [» ]
    1XCH X-ray 1.70 A 2-154 [» ]
    1YMA X-ray 2.00 A 2-154 [» ]
    1YMB X-ray 1.90 A 2-154 [» ]
    1YMC X-ray 2.00 A 2-154 [» ]
    2FRF X-ray 1.20 A 2-154 [» ]
    2FRI X-ray 1.60 X 2-154 [» ]
    2FRJ X-ray 1.30 X 2-154 [» ]
    2FRK X-ray 1.30 X 2-154 [» ]
    2IN4 X-ray 2.15 A 2-154 [» ]
    2NSR X-ray 1.90 A 2-154 [» ]
    2NSS X-ray 2.00 A 2-154 [» ]
    2O58 X-ray 1.65 X 2-154 [» ]
    2O5B X-ray 2.00 X 2-154 [» ]
    2O5L X-ray 1.70 X 2-154 [» ]
    2O5M X-ray 1.65 X 2-154 [» ]
    2O5O X-ray 1.60 X 2-154 [» ]
    2O5Q X-ray 1.90 X 2-154 [» ]
    2O5S X-ray 1.60 X 2-154 [» ]
    2O5T X-ray 1.60 X 2-154 [» ]
    2V1E X-ray 1.30 A 2-154 [» ]
    2V1F X-ray 1.20 A 2-154 [» ]
    2V1G X-ray 1.35 A 2-154 [» ]
    2V1H X-ray 1.30 A 2-154 [» ]
    2V1I X-ray 1.20 A 2-154 [» ]
    2V1J X-ray 1.40 A 2-154 [» ]
    2V1K X-ray 1.25 A 2-154 [» ]
    2VLX X-ray 1.30 A 2-154 [» ]
    2VLY X-ray 1.60 A 2-154 [» ]
    2VLZ X-ray 1.50 A 2-154 [» ]
    2VM0 X-ray 1.60 A 2-154 [» ]
    3BA2 X-ray 1.80 A 2-154 [» ]
    3HC9 X-ray 2.00 A 2-154 [» ]
    3HEN X-ray 1.90 A 2-154 [» ]
    3HEO X-ray 2.00 A 2-154 [» ]
    3HEP X-ray 1.95 A 2-154 [» ]
    3LR7 X-ray 1.60 A 2-154 [» ]
    3LR9 X-ray 1.55 A 2-154 [» ]
    3RJ6 X-ray 1.23 A/B 2-154 [» ]
    3RJN X-ray 1.90 B 2-154 [» ]
    3V2V X-ray 1.65 A 2-154 [» ]
    3V2Z X-ray 1.65 A 2-154 [» ]
    3VAU X-ray 1.70 A 2-154 [» ]
    3VM9 X-ray 1.05 A/B 2-154 [» ]
    3WI8 X-ray 2.20 A 2-154 [» ]
    4DC7 X-ray 1.50 A 2-153 [» ]
    4DC8 X-ray 1.50 A 2-153 [» ]
    ProteinModelPortali P68082.
    SMRi P68082. Positions 2-154.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P68082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000018976 ; ENSECAP00000015509 ; ENSECAG00000017982 .
    GeneIDi 100054434.
    KEGGi ecb:100054434.

    Organism-specific databases

    CTDi 4151.

    Phylogenomic databases

    eggNOGi NOG276460.
    GeneTreei ENSGT00730000110844.
    HOGENOMi HOG000070111.
    HOVERGENi HBG107340.
    InParanoidi P68082.
    OMAi DAQGAMN.
    OrthoDBi EOG7KSX9V.
    TreeFami TF332967.

    Enzyme and pathway databases

    SABIO-RK P68082.

    Miscellaneous databases

    EvolutionaryTracei P68082.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view ]
    PANTHERi PTHR11442:SF5. PTHR11442:SF5. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00613. MYOGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE OF 2-154.
      Tissue: Heart muscle.
    2. "Residue 122 of sperm whale and horse myoglobin."
      Romero-Herrera A.E., Lehmann H.
      Biochim. Biophys. Acta 336:318-323(1974)
      Cited for: PROTEIN SEQUENCE OF 2-154.
      Tissue: Skeletal muscle.
    3. "Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels."
      Jahnen W., Ward L.D., Reid G.E., Moritz R.L., Simpson R.J.
      Biochem. Biophys. Res. Commun. 166:139-145(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16 AND 57-71.
    4. "High-resolution study of the three-dimensional structure of horse heart metmyoglobin."
      Evans S.V., Brayer G.D.
      J. Mol. Biol. 213:885-897(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
    5. "Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination."
      Evans S.V., Brayer G.D.
      J. Biol. Chem. 263:4263-4268(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    6. "Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants."
      Bogumil R., Maurus R., Hildebrand D.P., Brayer G.D., Mauk A.G.
      Biochemistry 34:10483-10490(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT THR-65.
    7. "Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin."
      Chu K., Vojtchovsky J., McMahon B.H., Sweet R.M., Berendzen J., Schlichting I.
      Nature 403:921-923(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

    Entry informationi

    Entry nameiMYG_HORSE
    AccessioniPrimary (citable) accession number: P68082
    Secondary accession number(s): P02188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3