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P68082

- MYG_HORSE

UniProt

P68082 - MYG_HORSE

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Protein
Myoglobin
Gene
MB
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme distal ligand)
Metal bindingi94 – 941Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  1. brown fat cell differentiation Source: Ensembl
  2. enucleate erythrocyte differentiation Source: Ensembl
  3. heart development Source: Ensembl
  4. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP68082.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 28

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 154153Myoglobin
PRO_0000053302Add
BLAST

Proteomic databases

PRIDEiP68082.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915
Helixi22 – 3615
Helixi38 – 414
Helixi45 – 473
Helixi53 – 586
Helixi60 – 9637
Helixi102 – 11918
Turni121 – 1233
Helixi126 – 14924

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZIX-ray2.00A2-154[»]
1BJEX-ray1.80A2-154[»]
1DWRX-ray1.45A2-154[»]
1DWSX-ray1.45A2-154[»]
1DWTX-ray1.40A2-154[»]
1GJNX-ray1.35A2-154[»]
1HRMX-ray1.70A2-154[»]
1HSYX-ray1.90A2-154[»]
1NPFX-ray1.90A2-154[»]
1NPGX-ray1.70A2-154[»]
1NZ2X-ray1.90A2-154[»]
1NZ3X-ray1.60A2-154[»]
1NZ4X-ray1.80A2-154[»]
1NZ5X-ray1.70A2-154[»]
1RSEX-ray1.70A2-154[»]
1WLAX-ray1.70A2-154[»]
1XCHX-ray1.70A2-154[»]
1YMAX-ray2.00A2-154[»]
1YMBX-ray1.90A2-154[»]
1YMCX-ray2.00A2-154[»]
2FRFX-ray1.20A2-154[»]
2FRIX-ray1.60X2-154[»]
2FRJX-ray1.30X2-154[»]
2FRKX-ray1.30X2-154[»]
2IN4X-ray2.15A2-154[»]
2NSRX-ray1.90A2-154[»]
2NSSX-ray2.00A2-154[»]
2O58X-ray1.65X2-154[»]
2O5BX-ray2.00X2-154[»]
2O5LX-ray1.70X2-154[»]
2O5MX-ray1.65X2-154[»]
2O5OX-ray1.60X2-154[»]
2O5QX-ray1.90X2-154[»]
2O5SX-ray1.60X2-154[»]
2O5TX-ray1.60X2-154[»]
2V1EX-ray1.30A2-154[»]
2V1FX-ray1.20A2-154[»]
2V1GX-ray1.35A2-154[»]
2V1HX-ray1.30A2-154[»]
2V1IX-ray1.20A2-154[»]
2V1JX-ray1.40A2-154[»]
2V1KX-ray1.25A2-154[»]
2VLXX-ray1.30A2-154[»]
2VLYX-ray1.60A2-154[»]
2VLZX-ray1.50A2-154[»]
2VM0X-ray1.60A2-154[»]
3BA2X-ray1.80A2-154[»]
3HC9X-ray2.00A2-154[»]
3HENX-ray1.90A2-154[»]
3HEOX-ray2.00A2-154[»]
3HEPX-ray1.95A2-154[»]
3LR7X-ray1.60A2-154[»]
3LR9X-ray1.55A2-154[»]
3RJ6X-ray1.23A/B2-154[»]
3RJNX-ray1.90B2-154[»]
3V2VX-ray1.65A2-154[»]
3V2ZX-ray1.65A2-154[»]
3VAUX-ray1.70A2-154[»]
3VM9X-ray1.05A/B2-154[»]
3WI8X-ray2.20A2-154[»]
4DC7X-ray1.50A2-153[»]
4DC8X-ray1.50A2-153[»]
ProteinModelPortaliP68082.
SMRiP68082. Positions 2-154.

Miscellaneous databases

EvolutionaryTraceiP68082.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.

Phylogenomic databases

eggNOGiNOG276460.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP68082.
OMAiDAQGAMN.
OrthoDBiEOG7KSX9V.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68082-1 [UniParc]FASTAAdd to Basket

« Hide

MGLSDGEWQQ VLNVWGKVEA DIAGHGQEVL IRLFTGHPET LEKFDKFKHL    50
KTEAEMKASE DLKKHGTVVL TALGGILKKK GHHEAELKPL AQSHATKHKI 100
PIKYLEFISD AIIHVLHSKH PGDFGADAQG AMTKALELFR NDIAAKYKEL 150
GFQG 154
Length:154
Mass (Da):17,083
Last modified:January 23, 2007 - v2
Checksum:i20EABC4A66ACE975
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231D → N AA sequence 1 Publication

Sequence databases

PIRiA91098. MYHO.
RefSeqiNP_001157488.1. NM_001164016.1.
UniGeneiEca.16922.

Genome annotation databases

EnsembliENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
GeneIDi100054434.
KEGGiecb:100054434.

Cross-referencesi

Sequence databases

PIRi A91098. MYHO.
RefSeqi NP_001157488.1. NM_001164016.1.
UniGenei Eca.16922.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AZI X-ray 2.00 A 2-154 [» ]
1BJE X-ray 1.80 A 2-154 [» ]
1DWR X-ray 1.45 A 2-154 [» ]
1DWS X-ray 1.45 A 2-154 [» ]
1DWT X-ray 1.40 A 2-154 [» ]
1GJN X-ray 1.35 A 2-154 [» ]
1HRM X-ray 1.70 A 2-154 [» ]
1HSY X-ray 1.90 A 2-154 [» ]
1NPF X-ray 1.90 A 2-154 [» ]
1NPG X-ray 1.70 A 2-154 [» ]
1NZ2 X-ray 1.90 A 2-154 [» ]
1NZ3 X-ray 1.60 A 2-154 [» ]
1NZ4 X-ray 1.80 A 2-154 [» ]
1NZ5 X-ray 1.70 A 2-154 [» ]
1RSE X-ray 1.70 A 2-154 [» ]
1WLA X-ray 1.70 A 2-154 [» ]
1XCH X-ray 1.70 A 2-154 [» ]
1YMA X-ray 2.00 A 2-154 [» ]
1YMB X-ray 1.90 A 2-154 [» ]
1YMC X-ray 2.00 A 2-154 [» ]
2FRF X-ray 1.20 A 2-154 [» ]
2FRI X-ray 1.60 X 2-154 [» ]
2FRJ X-ray 1.30 X 2-154 [» ]
2FRK X-ray 1.30 X 2-154 [» ]
2IN4 X-ray 2.15 A 2-154 [» ]
2NSR X-ray 1.90 A 2-154 [» ]
2NSS X-ray 2.00 A 2-154 [» ]
2O58 X-ray 1.65 X 2-154 [» ]
2O5B X-ray 2.00 X 2-154 [» ]
2O5L X-ray 1.70 X 2-154 [» ]
2O5M X-ray 1.65 X 2-154 [» ]
2O5O X-ray 1.60 X 2-154 [» ]
2O5Q X-ray 1.90 X 2-154 [» ]
2O5S X-ray 1.60 X 2-154 [» ]
2O5T X-ray 1.60 X 2-154 [» ]
2V1E X-ray 1.30 A 2-154 [» ]
2V1F X-ray 1.20 A 2-154 [» ]
2V1G X-ray 1.35 A 2-154 [» ]
2V1H X-ray 1.30 A 2-154 [» ]
2V1I X-ray 1.20 A 2-154 [» ]
2V1J X-ray 1.40 A 2-154 [» ]
2V1K X-ray 1.25 A 2-154 [» ]
2VLX X-ray 1.30 A 2-154 [» ]
2VLY X-ray 1.60 A 2-154 [» ]
2VLZ X-ray 1.50 A 2-154 [» ]
2VM0 X-ray 1.60 A 2-154 [» ]
3BA2 X-ray 1.80 A 2-154 [» ]
3HC9 X-ray 2.00 A 2-154 [» ]
3HEN X-ray 1.90 A 2-154 [» ]
3HEO X-ray 2.00 A 2-154 [» ]
3HEP X-ray 1.95 A 2-154 [» ]
3LR7 X-ray 1.60 A 2-154 [» ]
3LR9 X-ray 1.55 A 2-154 [» ]
3RJ6 X-ray 1.23 A/B 2-154 [» ]
3RJN X-ray 1.90 B 2-154 [» ]
3V2V X-ray 1.65 A 2-154 [» ]
3V2Z X-ray 1.65 A 2-154 [» ]
3VAU X-ray 1.70 A 2-154 [» ]
3VM9 X-ray 1.05 A/B 2-154 [» ]
3WI8 X-ray 2.20 A 2-154 [» ]
4DC7 X-ray 1.50 A 2-153 [» ]
4DC8 X-ray 1.50 A 2-153 [» ]
ProteinModelPortali P68082.
SMRi P68082. Positions 2-154.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P68082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000018976 ; ENSECAP00000015509 ; ENSECAG00000017982 .
GeneIDi 100054434.
KEGGi ecb:100054434.

Organism-specific databases

CTDi 4151.

Phylogenomic databases

eggNOGi NOG276460.
GeneTreei ENSGT00730000110844.
HOGENOMi HOG000070111.
HOVERGENi HBG107340.
InParanoidi P68082.
OMAi DAQGAMN.
OrthoDBi EOG7KSX9V.
TreeFami TF332967.

Enzyme and pathway databases

SABIO-RK P68082.

Miscellaneous databases

EvolutionaryTracei P68082.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view ]
PANTHERi PTHR11442:SF5. PTHR11442:SF5. 1 hit.
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00613. MYOGLOBIN.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Heart muscle.
  2. "Residue 122 of sperm whale and horse myoglobin."
    Romero-Herrera A.E., Lehmann H.
    Biochim. Biophys. Acta 336:318-323(1974)
    Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Skeletal muscle.
  3. "Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels."
    Jahnen W., Ward L.D., Reid G.E., Moritz R.L., Simpson R.J.
    Biochem. Biophys. Res. Commun. 166:139-145(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16 AND 57-71.
  4. "High-resolution study of the three-dimensional structure of horse heart metmyoglobin."
    Evans S.V., Brayer G.D.
    J. Mol. Biol. 213:885-897(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  5. "Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination."
    Evans S.V., Brayer G.D.
    J. Biol. Chem. 263:4263-4268(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. "Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants."
    Bogumil R., Maurus R., Hildebrand D.P., Brayer G.D., Mauk A.G.
    Biochemistry 34:10483-10490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT THR-65.
  7. "Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin."
    Chu K., Vojtchovsky J., McMahon B.H., Sweet R.M., Berendzen J., Schlichting I.
    Nature 403:921-923(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

Entry informationi

Entry nameiMYG_HORSE
AccessioniPrimary (citable) accession number: P68082
Secondary accession number(s): P02188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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