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Protein

Myoglobin

Gene

MB

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1 Publication1
Metal bindingi94Iron (heme proximal ligand)Combined sources3 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKiP68082.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Protein family/group databases

Allergomei10877. Equ c Myoglobin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000533022 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP68082.
PRIDEiP68082.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015509.

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi22 – 36Combined sources15
Helixi38 – 41Combined sources4
Helixi45 – 47Combined sources3
Helixi53 – 58Combined sources6
Helixi60 – 96Combined sources37
Helixi102 – 119Combined sources18
Turni121 – 123Combined sources3
Helixi126 – 149Combined sources24
Turni150 – 153Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZIX-ray2.00A2-154[»]
1BJEX-ray1.80A2-154[»]
1DWRX-ray1.45A2-154[»]
1DWSX-ray1.45A2-154[»]
1DWTX-ray1.40A2-154[»]
1GJNX-ray1.35A2-154[»]
1HRMX-ray1.70A2-154[»]
1HSYX-ray1.90A2-154[»]
1NPFX-ray1.90A2-154[»]
1NPGX-ray1.70A2-154[»]
1NZ2X-ray1.90A2-154[»]
1NZ3X-ray1.60A2-154[»]
1NZ4X-ray1.80A2-154[»]
1NZ5X-ray1.70A2-154[»]
1RSEX-ray1.70A2-154[»]
1WLAX-ray1.70A2-154[»]
1XCHX-ray1.70A2-154[»]
1YMAX-ray2.00A2-154[»]
1YMBX-ray1.90A2-154[»]
1YMCX-ray2.00A2-154[»]
2FRFX-ray1.20A2-154[»]
2FRIX-ray1.60X2-154[»]
2FRJX-ray1.30X2-154[»]
2FRKX-ray1.30X2-154[»]
2IN4X-ray2.15A2-154[»]
2NSRX-ray1.90A2-154[»]
2NSSX-ray2.00A2-154[»]
2O58X-ray1.65X2-154[»]
2O5BX-ray2.00X2-154[»]
2O5LX-ray1.70X2-154[»]
2O5MX-ray1.65X2-154[»]
2O5OX-ray1.60X2-154[»]
2O5QX-ray1.90X2-154[»]
2O5SX-ray1.60X2-154[»]
2O5TX-ray1.60X2-154[»]
2V1EX-ray1.30A2-154[»]
2V1FX-ray1.20A2-154[»]
2V1GX-ray1.35A2-154[»]
2V1HX-ray1.30A2-154[»]
2V1IX-ray1.20A2-154[»]
2V1JX-ray1.40A2-154[»]
2V1KX-ray1.25A2-154[»]
2VLXX-ray1.30A2-154[»]
2VLYX-ray1.60A2-154[»]
2VLZX-ray1.50A2-154[»]
2VM0X-ray1.60A2-154[»]
3BA2X-ray1.80A2-154[»]
3HC9X-ray2.00A2-154[»]
3HENX-ray1.90A2-154[»]
3HEOX-ray2.00A2-154[»]
3HEPX-ray1.95A2-154[»]
3LR7X-ray1.60A2-154[»]
3LR9X-ray1.55A2-154[»]
3RJ6X-ray1.23A/B2-154[»]
3RJNX-ray1.90B2-154[»]
3V2VX-ray1.65A2-154[»]
3V2ZX-ray1.65A2-154[»]
3VAUX-ray1.70A2-154[»]
3VM9X-ray1.05A/B2-154[»]
3WFTX-ray1.30A2-154[»]
3WFUX-ray1.35A2-154[»]
3WI8X-ray2.20A2-154[»]
3WYOX-ray2.00A/B/C/D2-154[»]
4DC7X-ray1.50A2-153[»]
4DC8X-ray1.50A2-153[»]
4NS2X-ray1.18A1-154[»]
4TWUX-ray1.08A1-154[»]
4TWVX-ray1.06A1-154[»]
5AZQX-ray1.40A2-154[»]
5AZRX-ray1.20A2-154[»]
5CMVX-ray1.80A2-153[»]
5CN4X-ray1.80A2-153[»]
5CN5X-ray1.80A2-153[»]
5CN6X-ray1.80A2-153[»]
5CN7X-ray1.80A2-153[»]
5CN8X-ray1.80A2-153[»]
5CN9X-ray1.80A2-153[»]
5CNBX-ray1.80A2-153[»]
5CNCX-ray1.80A2-153[»]
5CNDX-ray1.80A2-153[»]
5CNEX-ray1.80A2-153[»]
5CNFX-ray1.80A2-153[»]
5CNGX-ray1.80A2-153[»]
5D5RX-ray1.60A2-153[»]
ProteinModelPortaliP68082.
SMRiP68082.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68082.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP68082.
KOiK21892.
OMAiLFRNDIA.
OrthoDBiEOG091G0OAO.
TreeFamiTF332967.

Family and domain databases

InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like_sf.
IPR002335. Myoglobin.
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQQ VLNVWGKVEA DIAGHGQEVL IRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGTVVL TALGGILKKK GHHEAELKPL AQSHATKHKI
110 120 130 140 150
PIKYLEFISD AIIHVLHSKH PGDFGADAQG AMTKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,083
Last modified:January 23, 2007 - v2
Checksum:i20EABC4A66ACE975
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123D → N AA sequence (PubMed:4902609).Curated1

Sequence databases

PIRiA91098. MYHO.
RefSeqiNP_001157488.1. NM_001164016.1.
UniGeneiEca.16922.

Genome annotation databases

EnsembliENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
GeneIDi100054434.
KEGGiecb:100054434.

Similar proteinsi

Entry informationi

Entry nameiMYG_HORSE
AccessioniPrimary (citable) accession number: P68082
Secondary accession number(s): P02188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families