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P68082 (MYG_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myoglobin
Gene names
Name:MB
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1 Ref.2 Ref.3
Chain2 – 154153Myoglobin
PRO_0000053302

Sites

Metal binding651Iron (heme distal ligand)
Metal binding941Iron (heme proximal ligand)

Experimental info

Sequence conflict1231D → N AA sequence Ref.1

Secondary structure

................... 154
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P68082 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 20EABC4A66ACE975

FASTA15417,083
        10         20         30         40         50         60 
MGLSDGEWQQ VLNVWGKVEA DIAGHGQEVL IRLFTGHPET LEKFDKFKHL KTEAEMKASE 

        70         80         90        100        110        120 
DLKKHGTVVL TALGGILKKK GHHEAELKPL AQSHATKHKI PIKYLEFISD AIIHVLHSKH 

       130        140        150 
PGDFGADAQG AMTKALELFR NDIAAKYKEL GFQG 

« Hide

References

[1]"Covalent structure of horse myoglobin."
Dautrevaux M., Boulanger Y., Han K., Biserte G.
Eur. J. Biochem. 11:267-277(1969) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-154.
Tissue: Heart muscle.
[2]"Residue 122 of sperm whale and horse myoglobin."
Romero-Herrera A.E., Lehmann H.
Biochim. Biophys. Acta 336:318-323(1974)
Cited for: PROTEIN SEQUENCE OF 2-154.
Tissue: Skeletal muscle.
[3]"Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels."
Jahnen W., Ward L.D., Reid G.E., Moritz R.L., Simpson R.J.
Biochem. Biophys. Res. Commun. 166:139-145(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-16 AND 57-71.
[4]"High-resolution study of the three-dimensional structure of horse heart metmyoglobin."
Evans S.V., Brayer G.D.
J. Mol. Biol. 213:885-897(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
[5]"Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination."
Evans S.V., Brayer G.D.
J. Biol. Chem. 263:4263-4268(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]"Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants."
Bogumil R., Maurus R., Hildebrand D.P., Brayer G.D., Mauk A.G.
Biochemistry 34:10483-10490(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT THR-65.
[7]"Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin."
Chu K., Vojtchovsky J., McMahon B.H., Sweet R.M., Berendzen J., Schlichting I.
Nature 403:921-923(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRMYHO. A91098.
RefSeqNP_001157488.1. NM_001164016.1.
UniGeneEca.16922.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZIX-ray2.00A2-154[»]
1BJEX-ray1.80A2-154[»]
1DWRX-ray1.45A2-154[»]
1DWSX-ray1.45A2-154[»]
1DWTX-ray1.40A2-154[»]
1GJNX-ray1.35A2-154[»]
1HRMX-ray1.70A2-154[»]
1HSYX-ray1.90A2-154[»]
1NPFX-ray1.90A2-154[»]
1NPGX-ray1.70A2-154[»]
1NZ2X-ray1.90A2-154[»]
1NZ3X-ray1.60A2-154[»]
1NZ4X-ray1.80A2-154[»]
1NZ5X-ray1.70A2-154[»]
1RSEX-ray1.70A2-154[»]
1WLAX-ray1.70A2-154[»]
1XCHX-ray1.70A2-154[»]
1YMAX-ray2.00A2-154[»]
1YMBX-ray1.90A2-154[»]
1YMCX-ray2.00A2-154[»]
2FRFX-ray1.20A2-154[»]
2FRIX-ray1.60X2-154[»]
2FRJX-ray1.30X2-154[»]
2FRKX-ray1.30X2-154[»]
2IN4X-ray2.15A2-154[»]
2NSRX-ray1.90A2-154[»]
2NSSX-ray2.00A2-154[»]
2O58X-ray1.65X2-154[»]
2O5BX-ray2.00X2-154[»]
2O5LX-ray1.70X2-154[»]
2O5MX-ray1.65X2-154[»]
2O5OX-ray1.60X2-154[»]
2O5QX-ray1.90X2-154[»]
2O5SX-ray1.60X2-154[»]
2O5TX-ray1.60X2-154[»]
2V1EX-ray1.30A2-154[»]
2V1FX-ray1.20A2-154[»]
2V1GX-ray1.35A2-154[»]
2V1HX-ray1.30A2-154[»]
2V1IX-ray1.20A2-154[»]
2V1JX-ray1.40A2-154[»]
2V1KX-ray1.25A2-154[»]
2VLXX-ray1.30A2-154[»]
2VLYX-ray1.60A2-154[»]
2VLZX-ray1.50A2-154[»]
2VM0X-ray1.60A2-154[»]
3BA2X-ray1.80A2-154[»]
3HC9X-ray2.00A2-154[»]
3HENX-ray1.90A2-154[»]
3HEOX-ray2.00A2-154[»]
3HEPX-ray1.95A2-154[»]
3LR7X-ray1.60A2-154[»]
3LR9X-ray1.55A2-154[»]
3RJ6X-ray1.23A/B2-154[»]
3RJNX-ray1.90B2-154[»]
3V2VX-ray1.65A2-154[»]
3V2ZX-ray1.65A2-154[»]
3VAUX-ray1.70A2-154[»]
3VM9X-ray1.05A/B2-154[»]
3WI8X-ray2.20A2-154[»]
4DC7X-ray1.50A2-153[»]
4DC8X-ray1.50A2-153[»]
ProteinModelPortalP68082.
SMRP68082. Positions 2-154.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP68082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000018976; ENSECAP00000015509; ENSECAG00000017982.
GeneID100054434.
KEGGecb:100054434.

Organism-specific databases

CTD4151.

Phylogenomic databases

eggNOGNOG276460.
GeneTreeENSGT00730000110844.
HOGENOMHOG000070111.
HOVERGENHBG107340.
InParanoidP68082.
OMADAQGAMN.
OrthoDBEOG7KSX9V.
TreeFamTF332967.

Enzyme and pathway databases

SABIO-RKP68082.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00613. MYOGLOBIN.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP68082.

Entry information

Entry nameMYG_HORSE
AccessionPrimary (citable) accession number: P68082
Secondary accession number(s): P02188
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references