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Protein

Actin, alpha cardiac muscle 1

Gene

Actc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

GO - Molecular functioni

GO - Biological processi

  • actin filament-based movement Source: MGI
  • actin-mediated cell contraction Source: MGI
  • actin-myosin filament sliding Source: MGI
  • actomyosin structure organization Source: MGI
  • cardiac muscle contraction Source: Ensembl
  • cardiac muscle tissue morphogenesis Source: MGI
  • cardiac myofibril assembly Source: MGI
  • heart contraction Source: MGI
  • mesenchyme migration Source: AgBase
  • negative regulation of apoptotic process Source: MGI
  • positive regulation of gene expression Source: AgBase
  • response to ethanol Source: Ensembl
  • skeletal muscle thin filament assembly Source: MGI

Keywordsi

Molecular functionMuscle protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, alpha cardiac muscle 1
Alternative name(s):
Alpha-cardiac actin
Cleaved into the following chain:
Gene namesi
Name:Actc1
Synonyms:Actc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:87905 Actc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00004429992 – 377Actin, alpha cardiac muscle 1, intermediate formBy similarityAdd BLAST376
ChainiPRO_00000008153 – 377Actin, alpha cardiac muscle 1By similarityAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine; in intermediate formBy similarity1
Modified residuei46Methionine (R)-sulfoxide1 Publication1
Modified residuei49Methionine (R)-sulfoxide1 Publication1
Modified residuei75Tele-methylhistidineBy similarity1
Modified residuei86N6-methyllysineBy similarity1

Post-translational modificationi

Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.1 Publication
Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity

Keywords - PTMi

Acetylation, Methylation, Oxidation

Proteomic databases

PaxDbiP68033
PeptideAtlasiP68033
PRIDEiP68033

PTM databases

iPTMnetiP68033
PhosphoSitePlusiP68033
SwissPalmiP68033

Expressioni

Gene expression databases

BgeeiENSMUSG00000068614
CleanExiMM_ACTC1
ExpressionAtlasiP68033 baseline and differential
GenevisibleiP68033 MM

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mybpc3O704683EBI-352284,EBI-8347074

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1979456 interactors.
IntActiP68033 4 interactors.
STRINGi10090.ENSMUSP00000087736

Structurei

3D structure databases

ProteinModelPortaliP68033
SMRiP68033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP68033
KOiK12314
OMAiKCDESIC
OrthoDBiEOG091G08LD
PhylomeDBiP68033
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG
60 70 80 90 100
QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP
110 120 130 140 150
EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY
210 220 230 240 250
SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI
260 270 280 290 300
TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
310 320 330 340 350
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIS KQEYDEAGPS IVHRKCF
Length:377
Mass (Da):42,019
Last modified:March 20, 1987 - v1
Checksum:iE5C10FA19730CAD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014303 mRNA Translation: BAB29258.1
BC062138 mRNA Translation: AAH62138.1
M15501 mRNA Translation: AAA37167.1
CCDSiCCDS16564.1
PIRiA54728
RefSeqiNP_033738.1, NM_009608.4
UniGeneiMm.686

Genome annotation databases

EnsembliENSMUST00000090269; ENSMUSP00000087736; ENSMUSG00000068614
GeneIDi11464
KEGGimmu:11464
UCSCiuc008lpz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACTC_MOUSE
AccessioniPrimary (citable) accession number: P68033
Secondary accession number(s): P04270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome