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Protein

Peptide YY

Gene

PYY

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Peptide YYPRO_0000044810Add
BLAST
Peptidei3 – 3634Peptide YY(3-36)By similarityPRO_0000430665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131Phosphoserine1 Publication
Modified residuei36 – 361Tyrosine amide

Post-translational modificationi

The peptide YY form is cleaved at Pro-2 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2 – 32Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Phosphoprotein

Proteomic databases

PaxDbiP68005.

PTM databases

iPTMnetiP68005.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: AgBase

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023751.

Structurei

Secondary structure

1
36
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Beta strandi11 – 155Combined sources
Turni16 – 227Combined sources
Helixi23 – 253Combined sources
Helixi26 – 305Combined sources
Beta strandi31 – 344Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QBFNMR-A1-36[»]
1RU5NMR-A1-36[»]
1RUUNMR-A1-36[»]
2OONNMR-A1-36[»]
2OOPNMR-A1-36[»]
2RLKNMR-A1-36[»]
ProteinModelPortaliP68005.
SMRiP68005. Positions 1-36.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68005.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG006484.
InParanoidiP68005.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
YPAKPEAPGE DASPEELSRY YASLRHYLNL VTRQRY
Length:36
Mass (Da):4,242
Last modified:July 21, 1986 - v1
Checksum:i02CD6B8C586DCC8D
GO

Sequence databases

PIRiA01574. YYPG.

Cross-referencesi

Sequence databases

PIRiA01574. YYPG.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QBFNMR-A1-36[»]
1RU5NMR-A1-36[»]
1RUUNMR-A1-36[»]
2OONNMR-A1-36[»]
2OOPNMR-A1-36[»]
2RLKNMR-A1-36[»]
ProteinModelPortaliP68005.
SMRiP68005. Positions 1-36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023751.

PTM databases

iPTMnetiP68005.

Proteomic databases

PaxDbiP68005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG006484.
InParanoidiP68005.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP68005.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion."
    Tatemoto K.
    Proc. Natl. Acad. Sci. U.S.A. 79:2514-2518(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Intestine.
  2. "Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity."
    Chen Z.-W., Eriste E., Jonsson A.P., Norberg A., Nepomuceno D., Lovenberg T.W., Bergman T., Efendic S., Joernvall H., Sillard R.
    FEBS Lett. 492:119-122(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY.
  3. "Solution structure of monomeric peptide YY supports the functional significance of the PP-fold."
    Keire D.A., Kobayashi M., Solomon T.E., Reeve J.R. Jr.
    Biochemistry 39:9935-9942(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  4. "Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors."
    Lerch M., Mayrhofer M., Zerbe O.
    J. Mol. Biol. 339:1153-1168(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPYY_PIG
AccessioniPrimary (citable) accession number: P68005
Secondary accession number(s): P01305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 17, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.