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Protein

Peptide YY

Gene

PYY

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448101 – 36Peptide YYAdd BLAST36
PeptideiPRO_00004306653 – 36Peptide YY(3-36)By similarityAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Phosphoserine1 Publication1
Modified residuei36Tyrosine amide1 Publication1

Post-translational modificationi

The peptide YY form is cleaved at Pro-2 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2 – 3Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Phosphoprotein

Proteomic databases

PaxDbiP68005.
PeptideAtlasiP68005.
PRIDEiP68005.

PTM databases

iPTMnetiP68005.

Expressioni

Gene expression databases

BgeeiENSSSCG00000025414.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: AgBase

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023751.

Structurei

Secondary structure

136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi11 – 15Combined sources5
Turni16 – 22Combined sources7
Helixi23 – 25Combined sources3
Helixi26 – 30Combined sources5
Beta strandi31 – 34Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QBFNMR-A1-36[»]
1RU5NMR-A1-36[»]
1RUUNMR-A1-36[»]
2OONNMR-A1-36[»]
2OOPNMR-A1-36[»]
2RLKNMR-A1-36[»]
ProteinModelPortaliP68005.
SMRiP68005.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68005.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG006484.
InParanoidiP68005.
OrthoDBiEOG091G0ZRE.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
YPAKPEAPGE DASPEELSRY YASLRHYLNL VTRQRY
Length:36
Mass (Da):4,242
Last modified:July 21, 1986 - v1
Checksum:i02CD6B8C586DCC8D
GO

Sequence databases

PIRiA01574. YYPG.
UniGeneiSsc.53428.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYY_PIG
AccessioniPrimary (citable) accession number: P68005
Secondary accession number(s): P01305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 12, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families