Skip Header

Contribute Send feedback
Read comments (?) or add your own

P68000 (COLI_BALBO) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-opiomelanocortin

Short name=POMC
Alternative name(s):
Corticotropin-lipotropin

Cleaved into the following 3 chains:

  1. Corticotropin
    Alternative name(s):
    Adrenocorticotropic hormone
    Short name=ACTH
  2. Melanotropin alpha
    Alternative name(s):
    Alpha-MSH
  3. Corticotropin-like intermediary peptide
    Short name=CLIP
Gene names
Name:POMC
OrganismBalaenoptera borealis (Sei whale) (Pollack whale)
Taxonomic identifier9768 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Protein attributes

Sequence length39 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ACTH stimulates the adrenal glands to release cortisol.

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.

Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular location

Secreted.

Tissue specificity

ACTH and MSH are produced by the pituitary gland.

Sequence similarities

Belongs to the POMC family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Phosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3939Corticotropin
PRO_0000024937
Peptide1 – 1313Melanotropin alpha
PRO_0000024938
Peptide19 – 3921Corticotropin-like intermediary peptide
PRO_0000024939

Amino acid modifications

Modified residue131Valine amide
Modified residue311Phosphoserine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue391

Sequences

Sequence LengthMass (Da)Tools
P68000 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 461FD46C28945A6E

FASTA394,541
        10         20         30 
SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF 

« Hide

References

[1]"Amino acid sequence of corticotropins from seiwhale (Balaenoptera borealis) and pinwhale (Balaenoptera physalus)."
Pankov Y.A., Nikolaeva O.P., Elizarova G.P.
Biokhimiia 42:2044-2050(1977) [PubMed: 201308] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRPN0127.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEP68000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
[Graphical view]
PANTHERPTHR11416. Mcortin_ACTH. 1 hit.
PfamPF00976. ACTH_domain. 1 hit.
[Graphical view]
PRINTSPR00383. MELANOCORTIN.
ProtoNetSearch...

Entry information

Entry nameCOLI_BALBO
AccessionPrimary (citable) accession number: P68000
Secondary accession number(s): P01195
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 21, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families