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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Balaenoptera borealis (Sei whale) (Pollack whale)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor protein for pituitary hormones that regulate stress and environmental adaptation.
Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 3 chains:
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Gene namesi
Name:POMC
OrganismiBalaenoptera borealis (Sei whale) (Pollack whale)
Taxonomic identifieri9768 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000249371 – 39CorticotropinAdd BLAST39
PeptideiPRO_00000249381 – 13Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_000002493919 – 39Corticotropin-like intermediary peptideAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserineBy similarity1
Modified residuei13Valine amideBy similarity1
Modified residuei31PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PRIDEiP68000.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP68000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013531. Mcrtin_ACTH_cent.
IPR001941. PMOC.
PfamiView protein in Pfam
PF00976. ACTH_domain. 1 hit.
PRINTSiPR00383. MELANOCORTIN.
SMARTiView protein in SMART
SM01363. ACTH_domain. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF
Length:39
Mass (Da):4,541
Last modified:July 21, 1986 - v1
Checksum:i461FD46C28945A6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei391

Sequence databases

PIRiPN0127.

Similar proteinsi

Entry informationi

Entry nameiCOLI_BALBO
AccessioniPrimary (citable) accession number: P68000
Secondary accession number(s): P01195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families