P68000 (COLI_BALBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pro-opiomelanocortin
Short name=POMC

Alternative name(s):
Corticotropin-lipotropin

Cleaved into the following 3 chains:

1. Corticotropin
   Alternative name(s):
   Adrenocorticotropic hormone
   Short name=ACTH
2. Melanotropin alpha
   Alternative name(s):
   Alpha-MSH
3. Corticotropin-like intermediary peptide
   Short name=CLIP

Gene names

Name:

POMC

Organism

Balaenoptera borealis (Sei whale) (Pollack whale)

Taxonomic identifier

9768 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera

Protein attributes

Sequence length	39 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular location	Secreted.
Tissue specificity	ACTH and MSH are produced by the pituitary gland.
Sequence similarities	Belongs to the POMC family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 39	39	Corticotropin		PRO_0000024937
	Peptide	1 – 13	13	Melanotropin alpha		PRO_0000024938
	Peptide	19 – 39	21	Corticotropin-like intermediary peptide		PRO_0000024939
Amino acid modifications
	Modified residue	13	1	Valine amide
	Modified residue	31	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	39	1

Sequences

	Sequence		Length	Mass (Da)
	P68000 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 461FD46C28945A6E	FASTA	39	4,541
	10 20 30 SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF

References

[1]	"Amino acid sequence of corticotropins from seiwhale (Balaenoptera borealis) and pinwhale (Balaenoptera physalus)." Pankov Y.A., Nikolaeva O.P., Elizarova G.P. Biokhimiia 42:2044-2050(1977) [PubMed: 201308] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	PN0127.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P68000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001941. Mcortin_ACTH. IPR013531. Mcrtin_ACTH_cent. [Graphical view]
PANTHER	PTHR11416. Mcortin_ACTH. 1 hit.
Pfam	PF00976. ACTH_domain. 1 hit. [Graphical view]
PRINTS	PR00383. MELANOCORTIN.
ProtoNet	Search...

Entry information

Entry name

COLI_BALBO

Accession

Primary (citable) accession number: P68000
Secondary accession number(s): P01195

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program