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Protein

60S ribosomal protein L22

Gene

Rpl22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • heparin binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • alpha-beta T cell differentiation Source: MGI
  • cytoplasmic translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Heparin-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Alternative name(s):
Heparin-binding protein HBp15
Gene namesi
Name:Rpl22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99262. Rpl22.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosolic large ribosomal subunit Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • focal adhesion Source: MGI
  • intracellular ribonucleoprotein complex Source: MGI
  • nucleus Source: MGI
  • ribosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002155022 – 12860S ribosomal protein L22Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphothreonineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei69N6-succinyllysineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP67984.
PaxDbiP67984.
PeptideAtlasiP67984.
PRIDEiP67984.

PTM databases

iPTMnetiP67984.
PhosphoSitePlusiP67984.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028936.
CleanExiMM_RPL22.
ExpressionAtlasiP67984. baseline and differential.
GenevisibleiP67984. MM.

Interactioni

Protein-protein interaction databases

BioGridi202971. 4 interactors.
IntActiP67984. 5 interactors.
MINTiMINT-1857768.
STRINGi10090.ENSMUSP00000099480.

Structurei

3D structure databases

ProteinModelPortaliP67984.
SMRiP67984.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 128Asp/Glu-rich (highly acidic)9

Sequence similaritiesi

Belongs to the ribosomal protein L22e family.Curated

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiP67984.
KOiK02891.
OMAiAPANDNI.
OrthoDBiEOG091G0POE.
PhylomeDBiP67984.
TreeFamiTF313018.

Family and domain databases

InterProiIPR002671. Ribosomal_L22e.
[Graphical view]
PANTHERiPTHR10064. PTHR10064. 1 hit.
PfamiPF01776. Ribosomal_L22e. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVKKLVAK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN
60 70 80 90 100
GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL
110 120
RVVANSKESY ELRYFQINQD EEEEEDED
Length:128
Mass (Da):14,759
Last modified:January 23, 2007 - v2
Checksum:i3F29D8BE70DEF96C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17653 mRNA. Translation: BAA04546.1.
BC007139 mRNA. Translation: AAH07139.1.
BC021344 mRNA. Translation: AAH21344.1.
CCDSiCCDS18999.1.
PIRiJC2119.
RefSeqiNP_033105.1. NM_009079.3.
UniGeneiMm.307846.

Genome annotation databases

EnsembliENSMUST00000103191; ENSMUSP00000099480; ENSMUSG00000028936.
ENSMUST00000139685; ENSMUSP00000118787; ENSMUSG00000028936.
ENSMUST00000188151; ENSMUSP00000140276; ENSMUSG00000028936.
GeneIDi19934.
KEGGimmu:19934.
UCSCiuc008wah.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17653 mRNA. Translation: BAA04546.1.
BC007139 mRNA. Translation: AAH07139.1.
BC021344 mRNA. Translation: AAH21344.1.
CCDSiCCDS18999.1.
PIRiJC2119.
RefSeqiNP_033105.1. NM_009079.3.
UniGeneiMm.307846.

3D structure databases

ProteinModelPortaliP67984.
SMRiP67984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202971. 4 interactors.
IntActiP67984. 5 interactors.
MINTiMINT-1857768.
STRINGi10090.ENSMUSP00000099480.

PTM databases

iPTMnetiP67984.
PhosphoSitePlusiP67984.

Proteomic databases

EPDiP67984.
PaxDbiP67984.
PeptideAtlasiP67984.
PRIDEiP67984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103191; ENSMUSP00000099480; ENSMUSG00000028936.
ENSMUST00000139685; ENSMUSP00000118787; ENSMUSG00000028936.
ENSMUST00000188151; ENSMUSP00000140276; ENSMUSG00000028936.
GeneIDi19934.
KEGGimmu:19934.
UCSCiuc008wah.2. mouse.

Organism-specific databases

CTDi6146.
MGIiMGI:99262. Rpl22.

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiP67984.
KOiK02891.
OMAiAPANDNI.
OrthoDBiEOG091G0POE.
PhylomeDBiP67984.
TreeFamiTF313018.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpl22. mouse.
PROiP67984.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028936.
CleanExiMM_RPL22.
ExpressionAtlasiP67984. baseline and differential.
GenevisibleiP67984. MM.

Family and domain databases

InterProiIPR002671. Ribosomal_L22e.
[Graphical view]
PANTHERiPTHR10064. PTHR10064. 1 hit.
PfamiPF01776. Ribosomal_L22e. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL22_MOUSE
AccessioniPrimary (citable) accession number: P67984
Secondary accession number(s): P41104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds to Epstein-Barr virus small RNAs and to heparin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.