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P67983

- MT1A_BOVIN

UniProt

P67983 - MT1A_BOVIN

Protein

Metallothionein-1A

Gene

MT1A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi15 – 151Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi29 – 291Divalent metal cation; cluster B
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi41 – 411Divalent metal cation; cluster A
    Metal bindingi44 – 441Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A

    GO - Molecular functioni

    1. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to zinc ion Source: UniProtKB
    2. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1A
    Short name:
    MT-1A
    Alternative name(s):
    MTC
    Metallothionein-IA
    Short name:
    MT-IA
    Gene namesi
    Name:MT1A
    Synonyms:MT-IA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-1APRO_0000197223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP67983.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP67983.
    SMRiP67983. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG138665.
    GeneTreeiENSGT00730000110883.
    HOGENOMiHOG000236262.
    HOVERGENiHBG096092.
    InParanoidiP67983.
    KOiK14739.
    OMAiFHGPPMN.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P67983-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCPTG GSCSCAGSCT CKACRCPSCK KSCCSCCPVG CAKCAQGCVC   50
    KGASDKCSCC A 61
    Length:61
    Mass (Da):5,951
    Last modified:August 13, 1987 - v1
    Checksum:iCB56570A19BC6995
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76977 Genomic DNA. Translation: AAA30637.1.
    BC142364 mRNA. Translation: AAI42365.1.
    RefSeqiNP_001035582.1. NM_001040492.2.
    UniGeneiBt.42866.

    Genome annotation databases

    EnsembliENSBTAT00000002092; ENSBTAP00000002092; ENSBTAG00000038067.
    GeneIDi404071.
    KEGGibta:404071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76977 Genomic DNA. Translation: AAA30637.1 .
    BC142364 mRNA. Translation: AAI42365.1 .
    RefSeqi NP_001035582.1. NM_001040492.2.
    UniGenei Bt.42866.

    3D structure databases

    ProteinModelPortali P67983.
    SMRi P67983. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P67983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002092 ; ENSBTAP00000002092 ; ENSBTAG00000038067 .
    GeneIDi 404071.
    KEGGi bta:404071.

    Organism-specific databases

    CTDi 4489.

    Phylogenomic databases

    eggNOGi NOG138665.
    GeneTreei ENSGT00730000110883.
    HOGENOMi HOG000236262.
    HOVERGENi HBG096092.
    InParanoidi P67983.
    KOi K14739.
    OMAi FHGPPMN.
    TreeFami TF336054.

    Miscellaneous databases

    NextBioi 20817530.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "Nucleotide sequence and characterization of bovine metallothionein gene."
      Yang J., Shen X.-Z., Yang W.-M., Peterson M.G., Mercer J.F.B., Woo S.L.C.
      Chin. Sci. Bull. 38:419-423(1993)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiMT1A_BOVIN
    AccessioniPrimary (citable) accession number: P67983
    Secondary accession number(s): A5PK56, P04356, P04902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3