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Protein

Insulin

Gene

INS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Biological processi

  • cell proliferation Source: AgBase
  • gene expression Source: AgBase
  • glucose metabolic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: AgBase
  • neural retina development Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

ReactomeiR-GGA-264876. Insulin processing.
R-GGA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-GGA-6807878. COPI-mediated anterograde transport.
R-GGA-74713. IRS activation.
R-GGA-74749. Signal attenuation.
R-GGA-74751. Insulin receptor signalling cascade.
R-GGA-74752. Signaling by Insulin receptor.
R-GGA-77387. Insulin receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:INS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Peptidei25 – 5430Insulin B chainPRO_0000015790Add
BLAST
Propeptidei57 – 8428C peptidePRO_0000015791Add
BLAST
Peptidei87 – 10721Insulin A chainPRO_0000015792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 93Interchain (between B and A chains)
Disulfide bondi43 ↔ 106Interchain (between B and A chains)
Disulfide bondi92 ↔ 97

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP67970.

Expressioni

Gene expression databases

ExpressionAtlasiP67970. baseline.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010567.

Structurei

3D structure databases

ProteinModelPortaliP67970.
SMRiP67970. Positions 27-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000261669.
HOVERGENiHBG006137.
InParanoidiP67970.
KOiK04526.
OMAiGFFYSPK.
OrthoDBiEOG7TF7CG.
PhylomeDBiP67970.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWIRSLPL LALLVFSGPG TSYAAANQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
SPKARRDVEQ PLVSSPLRGE AGVLPFQQEE YEKVKRGIVE QCCHNTCSLY

QLENYCN
Length:107
Mass (Da):11,981
Last modified:July 21, 1986 - v1
Checksum:i3D43C5D82B25DCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00416 Genomic DNA. Translation: CAA23707.1.
V00418 Genomic DNA. Translation: CAA23708.1.
X58993 mRNA. Translation: CAA41738.1.
AY438372 Genomic DNA. Translation: AAR13049.1.
PIRiA90796. IPCH.
RefSeqiNP_990553.1. NM_205222.3.
UniGeneiGga.673.

Genome annotation databases

EnsembliENSGALT00000010581; ENSGALP00000010567; ENSGALG00000006552.
GeneIDi396145.
KEGGigga:396145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00416 Genomic DNA. Translation: CAA23707.1.
V00418 Genomic DNA. Translation: CAA23708.1.
X58993 mRNA. Translation: CAA41738.1.
AY438372 Genomic DNA. Translation: AAR13049.1.
PIRiA90796. IPCH.
RefSeqiNP_990553.1. NM_205222.3.
UniGeneiGga.673.

3D structure databases

ProteinModelPortaliP67970.
SMRiP67970. Positions 27-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010567.

Proteomic databases

PaxDbiP67970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000010581; ENSGALP00000010567; ENSGALG00000006552.
GeneIDi396145.
KEGGigga:396145.

Organism-specific databases

CTDi3630.

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000261669.
HOVERGENiHBG006137.
InParanoidiP67970.
KOiK04526.
OMAiGFFYSPK.
OrthoDBiEOG7TF7CG.
PhylomeDBiP67970.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-GGA-264876. Insulin processing.
R-GGA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-GGA-6807878. COPI-mediated anterograde transport.
R-GGA-74713. IRS activation.
R-GGA-74749. Signal attenuation.
R-GGA-74751. Insulin receptor signalling cascade.
R-GGA-74752. Signaling by Insulin receptor.
R-GGA-77387. Insulin receptor recycling.

Miscellaneous databases

PROiP67970.

Gene expression databases

ExpressionAtlasiP67970. baseline.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The evolution of genes: the chicken preproinsulin gene."
    Perler F., Efstratiadis A., Lomedico P., Gilbert W., Kolodner R., Dodgson J.B.
    Cell 20:555-566(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation of a cDNA encoding chicken insulin precursor."
    Hasegawa S., Honda K., Nata K., Yonekura H., Okamoto H., Hikami Y.
    Anim. Sci. Technol. 62:867-869(1991)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  3. "Complete coding region of chicken preproinsulin gene."
    Nie Q., Fang M., Sun B., Lei M., Zhang X.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Species variation in the amino acid sequence of insulin."
    Smith L.F.
    Am. J. Med. 40:662-666(1966) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-54 AND 87-107.

Entry informationi

Entry nameiINS_CHICK
AccessioniPrimary (citable) accession number: P67970
Secondary accession number(s): P01332, Q53YX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.