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Protein

Cysteine and glycine-rich protein 1

Gene

CSRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • phosphoprotein binding Source: AgBase
  • poly(A) RNA binding Source: Ensembl
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Gene namesi
Name:CSRP1
Synonyms:CSRP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Associates with the actin cytoskeleton.1 Publication

GO - Cellular componenti

  • cell Source: AgBase
  • cell leading edge Source: AgBase
  • cytoplasm Source: AgBase
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: AgBase
  • stress fiber Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 192191Cysteine and glycine-rich protein 1PRO_0000075719Add
BLAST

Proteomic databases

PaxDbiP67966.

Expressioni

Tissue specificityi

Most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine. Lower level in the heart, no expression in liver, skeletal muscle, or brain.1 Publication

Developmental stagei

Expression levels increase dramatically during smooth muscle maturation.

Gene expression databases

BgeeiENSGALG00000000318.

Interactioni

Subunit structurei

Probable monomer. Interacts with ZYX.2 Publications

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • phosphoprotein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039973.

Structurei

Secondary structure

1
192
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni11 – 133Combined sources
Beta strandi23 – 253Combined sources
Beta strandi28 – 303Combined sources
Turni32 – 343Combined sources
Turni38 – 403Combined sources
Beta strandi46 – 527Combined sources
Beta strandi55 – 584Combined sources
Helixi59 – 668Combined sources
Beta strandi110 – 1178Combined sources
Turni119 – 1213Combined sources
Beta strandi127 – 1293Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi136 – 1383Combined sources
Turni140 – 1423Combined sources
Turni146 – 1483Combined sources
Beta strandi154 – 1607Combined sources
Beta strandi163 – 1664Combined sources
Helixi167 – 1737Combined sources
Beta strandi180 – 1823Combined sources
Turni189 – 1913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8TNMR-A1-192[»]
1CTLNMR-A108-192[»]
ProteinModelPortaliP67966.
SMRiP67966. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67966.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 16952LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 696Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7816Gly-richAdd
BLAST
Compositional biasi175 – 18612Gly-richAdd
BLAST

Domaini

Glycine-rich repeats mediate the association with the actin cytoskeleton.Curated

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP67966.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP67966.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKAVYFA EEVQCEGSSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGDEIYCKS CYGKKYGPKG YGYGMGAGTL STDKGESLGI KYEEGQSHRP
110 120 130 140 150
TNPNASRMAQ KVGGSDGCPR CGQAVYAAEK VIGAGKSWHK SCFRCAKCGK
160 170 180 190
SLESTTLADK DGEIYCKGCY AKNFGPKGFG FGQGAGALIH SQ
Length:192
Mass (Da):20,385
Last modified:January 23, 2007 - v2
Checksum:i43D3D301938BBCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73831 mRNA. Translation: CAA52053.1.
PIRiA49648.
B44358.
C44358.
RefSeqiNP_990579.1. NM_205248.1.
XP_015154179.1. XM_015298693.1.
UniGeneiGga.693.

Genome annotation databases

EnsembliENSGALT00000000424; ENSGALP00000000423; ENSGALG00000000318.
GeneIDi396176.
KEGGigga:396176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73831 mRNA. Translation: CAA52053.1.
PIRiA49648.
B44358.
C44358.
RefSeqiNP_990579.1. NM_205248.1.
XP_015154179.1. XM_015298693.1.
UniGeneiGga.693.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8TNMR-A1-192[»]
1CTLNMR-A108-192[»]
ProteinModelPortaliP67966.
SMRiP67966. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039973.

Proteomic databases

PaxDbiP67966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000424; ENSGALP00000000423; ENSGALG00000000318.
GeneIDi396176.
KEGGigga:396176.

Organism-specific databases

CTDi1465.

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP67966.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP67966.

Miscellaneous databases

EvolutionaryTraceiP67966.
PROiP67966.

Gene expression databases

BgeeiENSGALG00000000318.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP1_CHICK
AccessioniPrimary (citable) accession number: P67966
Secondary accession number(s): P32965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.