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Protein

Cysteine and glycine-rich protein 1

Gene

CSRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • phosphoprotein binding Source: AgBase
  • poly(A) RNA binding Source: Ensembl
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Gene namesi
Name:CSRP1
Synonyms:CSRP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Associates with the actin cytoskeleton.1 Publication

GO - Cellular componenti

  • cell Source: AgBase
  • cell leading edge Source: AgBase
  • cytoplasm Source: AgBase
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: AgBase
  • nucleus Source: UniProtKB-SubCell
  • stress fiber Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000757192 – 192Cysteine and glycine-rich protein 1Add BLAST191

Proteomic databases

PaxDbiP67966.

Expressioni

Tissue specificityi

Most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine. Lower level in the heart, no expression in liver, skeletal muscle, or brain.1 Publication

Developmental stagei

Expression levels increase dramatically during smooth muscle maturation.

Gene expression databases

BgeeiENSGALG00000000318.

Interactioni

Subunit structurei

Probable monomer. Interacts with ZYX.2 Publications

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • phosphoprotein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039973.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 13Combined sources3
Beta strandi23 – 25Combined sources3
Beta strandi28 – 30Combined sources3
Turni32 – 34Combined sources3
Turni38 – 40Combined sources3
Beta strandi46 – 52Combined sources7
Beta strandi55 – 58Combined sources4
Helixi59 – 66Combined sources8
Beta strandi110 – 117Combined sources8
Turni119 – 121Combined sources3
Beta strandi127 – 129Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi136 – 138Combined sources3
Turni140 – 142Combined sources3
Turni146 – 148Combined sources3
Beta strandi154 – 160Combined sources7
Beta strandi163 – 166Combined sources4
Helixi167 – 173Combined sources7
Beta strandi180 – 182Combined sources3
Turni189 – 191Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8TNMR-A1-192[»]
1CTLNMR-A108-192[»]
ProteinModelPortaliP67966.
SMRiP67966.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67966.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini118 – 169LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi175 – 186Gly-richAdd BLAST12

Domaini

Glycine-rich repeats mediate the association with the actin cytoskeleton.Curated

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP67966.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP67966.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKAVYFA EEVQCEGSSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGDEIYCKS CYGKKYGPKG YGYGMGAGTL STDKGESLGI KYEEGQSHRP
110 120 130 140 150
TNPNASRMAQ KVGGSDGCPR CGQAVYAAEK VIGAGKSWHK SCFRCAKCGK
160 170 180 190
SLESTTLADK DGEIYCKGCY AKNFGPKGFG FGQGAGALIH SQ
Length:192
Mass (Da):20,385
Last modified:January 23, 2007 - v2
Checksum:i43D3D301938BBCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73831 mRNA. Translation: CAA52053.1.
PIRiA49648.
B44358.
C44358.
RefSeqiNP_990579.1. NM_205248.1.
XP_015154179.1. XM_015298693.1.
UniGeneiGga.693.

Genome annotation databases

EnsembliENSGALT00000000424; ENSGALP00000000423; ENSGALG00000000318.
GeneIDi396176.
KEGGigga:396176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73831 mRNA. Translation: CAA52053.1.
PIRiA49648.
B44358.
C44358.
RefSeqiNP_990579.1. NM_205248.1.
XP_015154179.1. XM_015298693.1.
UniGeneiGga.693.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8TNMR-A1-192[»]
1CTLNMR-A108-192[»]
ProteinModelPortaliP67966.
SMRiP67966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039973.

Proteomic databases

PaxDbiP67966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000424; ENSGALP00000000423; ENSGALG00000000318.
GeneIDi396176.
KEGGigga:396176.

Organism-specific databases

CTDi1465.

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP67966.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP67966.

Miscellaneous databases

EvolutionaryTraceiP67966.
PROiP67966.

Gene expression databases

BgeeiENSGALG00000000318.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP1_CHICK
AccessioniPrimary (citable) accession number: P67966
Secondary accession number(s): P32965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.