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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000002339227 – 216Vascular endothelial growth factor AAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 94By similarity
Disulfide bondi77InterchainBy similarity
Disulfide bondi83 ↔ 128By similarity
Disulfide bondi86InterchainBy similarity
Disulfide bondi87 ↔ 130By similarity
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP67964.

Expressioni

Gene expression databases

BgeeiENSGALG00000010290.
ExpressionAtlasiP67964. baseline and differential.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016723.

Structurei

3D structure databases

ProteinModelPortaliP67964.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP67964.
KOiK05448.
OrthoDBiEOG09070A74.
PhylomeDBiP67964.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
PfamiView protein in Pfam
PF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
SMARTiView protein in SMART
SM00141. PDGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiView protein in PROSITE
PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLLTWIHW GLAALLYLQS AELSKAAPAL GDGERKPNEV IKFLEVYERS
60 70 80 90 100
FCRTIETLVD IFQEYPDEVE YIFRPSCVPL MRCAGCCGDE GLECVPVDVY
110 120 130 140 150
NVTMEIARIK PHQSQHIAHM SFLQHSKCDC RPKKDVKNKQ EKKSKRGKGK
160 170 180 190 200
GQKRKRKKGR YKPPSFHCEP CSERRKHLFV QDPQTCKCSC KFTDSRCKSR
210
QLELNERTCR CEKPRR
Length:216
Mass (Da):25,203
Last modified:October 11, 2004 - v1
Checksum:i82E669C2F6FC6DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011078 mRNA. Translation: BAA24925.1.
RefSeqiNP_001103825.1. NM_001110355.1.
NP_990373.1. NM_205042.2.
UniGeneiGga.537.

Genome annotation databases

EnsembliENSGALT00000016742; ENSGALP00000016723; ENSGALG00000010290.
GeneIDi395909.
KEGGigga:395909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011078 mRNA. Translation: BAA24925.1.
RefSeqiNP_001103825.1. NM_001110355.1.
NP_990373.1. NM_205042.2.
UniGeneiGga.537.

3D structure databases

ProteinModelPortaliP67964.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016723.

Proteomic databases

PaxDbiP67964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016742; ENSGALP00000016723; ENSGALG00000010290.
GeneIDi395909.
KEGGigga:395909.

Organism-specific databases

CTDi7422.

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP67964.
KOiK05448.
OrthoDBiEOG09070A74.
PhylomeDBiP67964.

Miscellaneous databases

PROiP67964.

Gene expression databases

BgeeiENSGALG00000010290.
ExpressionAtlasiP67964. baseline and differential.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
PfamiView protein in Pfam
PF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
SMARTiView protein in SMART
SM00141. PDGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiView protein in PROSITE
PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVEGFA_CHICK
AccessioniPrimary (citable) accession number: P67964
Secondary accession number(s): P52582, Q91420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 15, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.