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Protein

Neurokinin-B

Gene

TAC3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-380095 Tachykinin receptors bind tachykinins
R-SSC-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:TAC3
Synonyms:NKNB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000039786421 – 83By similarityAdd BLAST63
PeptideiPRO_000004442886 – 95Neurokinin-B10
PropeptideiPRO_000039786599 – 126By similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95Methionine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP67934
PRIDEiP67934

Expressioni

Gene expression databases

ExpressionAtlasiP67934 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000446

Structurei

3D structure databases

SMRiP67934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH Eukaryota
ENOG4111D7S LUCA
GeneTreeiENSGT00390000000335
HOGENOMiHOG000154597
HOVERGENiHBG079264
InParanoidiP67934
KOiK05240

Family and domain databases

InterProiView protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS
PANTHERiPTHR15536 PTHR15536, 1 hit
PfamiView protein in Pfam
PF03823 Neurokinin_B, 1 hit
PIRSFiPIRSF001843 Neurokinin, 1 hit
PRINTSiPR01828 NEUROKININB
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTLLFVAI LALSLAWSLG AACEESQEQL MPGGGHSKKD SNLYQLPSSL
60 70 80 90 100
LRRLCDSRSI SLDGLLKMLS KASVGAKESS LPQKRDMHDF FVGLMGKRNI
110 120
QPGTPVDGNQ ENAPSLGTFK YPPSVE
Length:126
Mass (Da):13,651
Last modified:October 5, 2010 - v2
Checksum:i9B06D7A11CE61C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY758208 Genomic DNA Translation: AAV32522.1
AY769936 mRNA Translation: AAV37188.1
PIRiA01560 SPPGNK
RefSeqiNP_001007197.1, NM_001007196.1
UniGeneiSsc.19565

Genome annotation databases

EnsembliENSSSCT00000000452; ENSSSCP00000000446; ENSSSCG00000000418
GeneIDi492314
KEGGissc:492314

Similar proteinsi

Entry informationi

Entry nameiTKNK_PIG
AccessioniPrimary (citable) accession number: P67934
Secondary accession number(s): P01292, Q5UAF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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