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P67920

- BLA1_ACTPL

UniProt

P67920 - BLA1_ACTPL

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Protein
Beta-lactamase ROB-1
Gene
rob1, bla
Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase ROB-1 (EC:3.5.2.6)
Gene namesi
Name:rob1
Synonyms:bla
Encoded oniPlasmid RRob0 Publication
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 305272Beta-lactamase ROB-1
PRO_0000017039Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP67920.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2503Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67920-1 [UniParc]FASTAAdd to Basket

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MLNKLKIGTL LLLTLTACSP NSVHSVTSNP QPASAPVQQS ATQATFQQTL    50
ANLEQQYQAR IGVYVWDTET GHSLSYRADE RFAYASTFKA LLAGAVLQSL 100
PEKDLNRTIS YSQKDLVSYS PETQKYVGKG MTIAQLCEAA VRFSDNSATN 150
LLLKELGGVE QYQRILRQLG DNVTHTNRLE PDLNQAKPND IRDTSTPKQM 200
AMNLNAYLLG NTLTESQKTI LWNWLDNNAT GNPLIRAATP TSWKVYDKSG 250
AGKYGVRNDI AVVRIPNRKP IVMAIMSTQF TEEAKFNNKL VEDAAKQVFH 300
TLQLN 305
Length:305
Mass (Da):33,869
Last modified:October 11, 2004 - v1
Checksum:i6146E12B76607422
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S51028 Genomic DNA. Translation: AAB24384.1.
PIRiA57002.
RefSeqiYP_001941143.1. NC_010795.1.

Genome annotation databases

GeneIDi6353537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S51028 Genomic DNA. Translation: AAB24384.1 .
PIRi A57002.
RefSeqi YP_001941143.1. NC_010795.1.

3D structure databases

ProteinModelPortali P67920.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6353537.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the ROB-1 beta-lactamase gene from Actinobacillus pleuropneumoniae."
    Chang Y.-F., Shi J., Shin S.J., Lein D.H.
    Vet. Microbiol. 32:319-325(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBLA1_ACTPL
AccessioniPrimary (citable) accession number: P67920
Secondary accession number(s): P33949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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