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P67919

- BLA1_PASHA

UniProt

P67919 - BLA1_PASHA

Protein

Beta-lactamase ROB-1

Gene

rob1

Organism
Pasteurella haemolytica (Mannheimia haemolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase ROB-1 (EC:3.5.2.6)
    Gene namesi
    Name:rob1
    Synonyms:bla
    Encoded oniPlasmid RRob1 Publication
    Plasmid pAB21 Publication
    OrganismiPasteurella haemolytica (Mannheimia haemolytica)
    Taxonomic identifieri75985 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 305272Beta-lactamase ROB-1PRO_0000017041Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP67919.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2503Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P67919-1 [UniParc]FASTAAdd to Basket

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    MLNKLKIGTL LLLTLTACSP NSVHSVTSNP QPASAPVQQS ATQATFQQTL    50
    ANLEQQYQAR IGVYVWDTET GHSLSYRADE RFAYASTFKA LLAGAVLQSL 100
    PEKDLNRTIS YSQKDLVSYS PETQKYVGKG MTIAQLCEAA VRFSDNSATN 150
    LLLKELGGVE QYQRILRQLG DNVTHTNRLE PDLNQAKPND IRDTSTPKQM 200
    AMNLNAYLLG NTLTESQKTI LWNWLDNNAT GNPLIRAATP TSWKVYDKSG 250
    AGKYGVRNDI AVVRIPNRKP IVMAIMSTQF TEEAKFNNKL VEDAAKQVFH 300
    TLQLN 305
    Length:305
    Mass (Da):33,869
    Last modified:October 11, 2004 - v1
    Checksum:i6146E12B76607422
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52872 Genomic DNA. Translation: CAA37052.1.
    Z21724 Genomic DNA. Translation: CAA79823.1.
    PIRiA61156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52872 Genomic DNA. Translation: CAA37052.1 .
    Z21724 Genomic DNA. Translation: CAA79823.1 .
    PIRi A61156.

    3D structure databases

    ProteinModelPortali P67919.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and molecular characterization of the ROB-1 beta-lactamase gene from Pasteurella haemolytica."
      Livrelli V., Peduzzi J., Joly B.
      Antimicrob. Agents Chemother. 35:242-251(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LNPB 51.
      Plasmid: RRob
    2. "A native plasmid of Pasteurella haemolytica serotype A1: DNA sequence analysis and investigation of its potential as a vector."
      Wood A.R., Lainson F.A., Wright F., Baird G.D., Donachie W.
      Res. Vet. Sci. 58:163-168(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Serotype A1.
      Plasmid: pAB2

    Entry informationi

    Entry nameiBLA1_PASHA
    AccessioniPrimary (citable) accession number: P67919
    Secondary accession number(s): P33949
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3