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P67918 (BLA1_HAEIF) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase ROB-1

EC=3.5.2.6
Gene names
Name:rob1
Synonyms:bla
Encoded onPlasmid RRob Ref.1
OrganismHaemophilus influenzae
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 305272Beta-lactamase ROB-1
PRO_0000017040

Regions

Region248 – 2503Substrate binding By similarity

Sites

Active site861Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P67918 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6146E12B76607422

FASTA30533,869
        10         20         30         40         50         60 
MLNKLKIGTL LLLTLTACSP NSVHSVTSNP QPASAPVQQS ATQATFQQTL ANLEQQYQAR 

        70         80         90        100        110        120 
IGVYVWDTET GHSLSYRADE RFAYASTFKA LLAGAVLQSL PEKDLNRTIS YSQKDLVSYS 

       130        140        150        160        170        180 
PETQKYVGKG MTIAQLCEAA VRFSDNSATN LLLKELGGVE QYQRILRQLG DNVTHTNRLE 

       190        200        210        220        230        240 
PDLNQAKPND IRDTSTPKQM AMNLNAYLLG NTLTESQKTI LWNWLDNNAT GNPLIRAATP 

       250        260        270        280        290        300 
TSWKVYDKSG AGKYGVRNDI AVVRIPNRKP IVMAIMSTQF TEEAKFNNKL VEDAAKQVFH 


TLQLN 

« Hide

References

[1]"Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase."
Juteau J.-M., Levesque R.C.
Antimicrob. Agents Chemother. 34:1354-1359(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: F990.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022114 Genomic DNA. Translation: AAB72007.1.
PIRA60680.
RefSeqYP_004074575.1. NC_014813.1.
YP_006959620.1. NC_019174.1.
YP_006959624.1. NC_019175.1.
YP_006959628.1. NC_019176.1.
YP_006959632.1. NC_019177.1.
YP_006959636.1. NC_019178.1.

3D structure databases

ProteinModelPortalP67918.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10044397.
13915049.
13915055.
13915061.
13915067.
13915073.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA1_HAEIF
AccessionPrimary (citable) accession number: P67918
Secondary accession number(s): P33949
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 13, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families