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P67918

- BLA1_HAEIF

UniProt

P67918 - BLA1_HAEIF

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Protein

Beta-lactamase ROB-1

Gene

rob1

Organism
Haemophilus influenzae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase ROB-1 (EC:3.5.2.6)
Gene namesi
Name:rob1
Synonyms:bla
Encoded oniPlasmid RRob1 Publication
OrganismiHaemophilus influenzae
Taxonomic identifieri727 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 305272Beta-lactamase ROB-1PRO_0000017040Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP67918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2503Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNKLKIGTL LLLTLTACSP NSVHSVTSNP QPASAPVQQS ATQATFQQTL
60 70 80 90 100
ANLEQQYQAR IGVYVWDTET GHSLSYRADE RFAYASTFKA LLAGAVLQSL
110 120 130 140 150
PEKDLNRTIS YSQKDLVSYS PETQKYVGKG MTIAQLCEAA VRFSDNSATN
160 170 180 190 200
LLLKELGGVE QYQRILRQLG DNVTHTNRLE PDLNQAKPND IRDTSTPKQM
210 220 230 240 250
AMNLNAYLLG NTLTESQKTI LWNWLDNNAT GNPLIRAATP TSWKVYDKSG
260 270 280 290 300
AGKYGVRNDI AVVRIPNRKP IVMAIMSTQF TEEAKFNNKL VEDAAKQVFH

TLQLN
Length:305
Mass (Da):33,869
Last modified:October 11, 2004 - v1
Checksum:i6146E12B76607422
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022114 Genomic DNA. Translation: AAB72007.1.
PIRiA60680.
RefSeqiYP_004074575.1. NC_014813.1.
YP_006959620.1. NC_019174.1.
YP_006959624.1. NC_019175.1.
YP_006959628.1. NC_019176.1.
YP_006959632.1. NC_019177.1.
YP_006959636.1. NC_019178.1.

Genome annotation databases

GeneIDi10044397.
13915049.
13915055.
13915061.
13915067.
13915073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022114 Genomic DNA. Translation: AAB72007.1 .
PIRi A60680.
RefSeqi YP_004074575.1. NC_014813.1.
YP_006959620.1. NC_019174.1.
YP_006959624.1. NC_019175.1.
YP_006959628.1. NC_019176.1.
YP_006959632.1. NC_019177.1.
YP_006959636.1. NC_019178.1.

3D structure databases

ProteinModelPortali P67918.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10044397.
13915049.
13915055.
13915061.
13915067.
13915073.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase."
    Juteau J.-M., Levesque R.C.
    Antimicrob. Agents Chemother. 34:1354-1359(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: F990.
    Plasmid: RRob

Entry informationi

Entry nameiBLA1_HAEIF
AccessioniPrimary (citable) accession number: P67918
Secondary accession number(s): P33949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3