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P67881

- CYC_CHICK

UniProt

P67881 - CYC_CHICK

Protein

Cytochrome c

Gene

CYC

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Binding sitei18 – 181Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Metal bindingi19 – 191Iron (heme axial ligand)
    Metal bindingi81 – 811Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_189537. Detoxification of Reactive Oxygen Species.
    REACT_217196. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c
    Gene namesi
    Name:CYC
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    Mitochondrion intermembrane space
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 105104Cytochrome cPRO_0000108239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP67881.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037050.

    Structurei

    3D structure databases

    ProteinModelPortaliP67881.
    SMRiP67881. Positions 2-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    HOGENOMiHOG000009762.
    HOVERGENiHBG003023.
    InParanoidiP67881.
    KOiK08738.
    OrthoDBiEOG761BWX.
    PhylomeDBiP67881.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P67881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDIEKGKKI FVQKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAEGFSYT    50
    DANKNKGITW GEDTLMEYLE NPKKYIPGTK MIFAGIKKKS ERVDLIAYLK 100
    DATSK 105
    Length:105
    Mass (Da):11,711
    Last modified:January 23, 2007 - v2
    Checksum:i293CEF5B11DABC36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02303 Genomic DNA. Translation: AAA48741.1.
    X00230 Genomic DNA. Translation: CAA25046.1.
    PIRiA00014. CCCH.
    RefSeqiNP_001072946.1. NM_001079478.1.
    UniGeneiGga.48682.

    Genome annotation databases

    EnsembliENSGALT00000017955; ENSGALP00000017934; ENSGALG00000011020.
    GeneIDi420624.
    KEGGigga:420624.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02303 Genomic DNA. Translation: AAA48741.1 .
    X00230 Genomic DNA. Translation: CAA25046.1 .
    PIRi A00014. CCCH.
    RefSeqi NP_001072946.1. NM_001079478.1.
    UniGenei Gga.48682.

    3D structure databases

    ProteinModelPortali P67881.
    SMRi P67881. Positions 2-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037050.

    Proteomic databases

    PaxDbi P67881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000017955 ; ENSGALP00000017934 ; ENSGALG00000011020 .
    GeneIDi 420624.
    KEGGi gga:420624.

    Organism-specific databases

    CTDi 54205.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    HOGENOMi HOG000009762.
    HOVERGENi HBG003023.
    InParanoidi P67881.
    KOi K08738.
    OrthoDBi EOG761BWX.
    PhylomeDBi P67881.

    Enzyme and pathway databases

    Reactomei REACT_189537. Detoxification of Reactive Oxygen Species.
    REACT_217196. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    NextBioi 20823511.
    PROi P67881.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two alleles of the chicken cytochrome c gene."
      Limbach K.J., Wu R.
      Nucleic Acids Res. 11:8931-8950(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Amino acid sequence of chicken heart cytochrome c."
      Chan S.K., Margoliash E.
      J. Biol. Chem. 241:507-515(1966) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.
      Tissue: Heart.

    Entry informationi

    Entry nameiCYC_CHICK
    AccessioniPrimary (citable) accession number: P67881
    Secondary accession number(s): P00016, Q9PRU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3