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P67881 (CYC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
Gene names
Name:CYC
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 105104Cytochrome c
PRO_0000108239

Sites

Metal binding191Iron (heme axial ligand)
Metal binding811Iron (heme axial ligand)
Binding site151Heme (covalent) Ref.2
Binding site181Heme (covalent) Ref.2

Amino acid modifications

Modified residue21N-acetylglycine Ref.2

Sequences

Sequence LengthMass (Da)Tools
P67881 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 293CEF5B11DABC36

FASTA10511,711
        10         20         30         40         50         60 
MGDIEKGKKI FVQKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAEGFSYT DANKNKGITW 

        70         80         90        100 
GEDTLMEYLE NPKKYIPGTK MIFAGIKKKS ERVDLIAYLK DATSK 

« Hide

References

[1]"Isolation and characterization of two alleles of the chicken cytochrome c gene."
Limbach K.J., Wu R.
Nucleic Acids Res. 11:8931-8950(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Amino acid sequence of chicken heart cytochrome c."
Chan S.K., Margoliash E.
J. Biol. Chem. 241:507-515(1966) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.
Tissue: Heart.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02303 Genomic DNA. Translation: AAA48741.1.
X00230 Genomic DNA. Translation: CAA25046.1.
PIRCCCH. A00014.
RefSeqNP_001072946.1. NM_001079478.1.
UniGeneGga.48682.

3D structure databases

ProteinModelPortalP67881.
SMRP67881. Positions 2-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037050.

Proteomic databases

PaxDbP67881.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000017955; ENSGALP00000017934; ENSGALG00000011020.
GeneID420624.
KEGGgga:420624.

Organism-specific databases

CTD54205.

Phylogenomic databases

eggNOGCOG3474.
GeneTreeENSGT00390000009405.
HOGENOMHOG000009762.
HOVERGENHBG003023.
InParanoidP67881.
KOK08738.
OrthoDBEOG761BWX.
PhylomeDBP67881.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20823511.
PROP67881.

Entry information

Entry nameCYC_CHICK
AccessionPrimary (citable) accession number: P67881
Secondary accession number(s): P00016, Q9PRU4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries