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Protein

Cytochrome c

Gene

CYC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)PROSITE-ProRule annotation1 Publication
Binding sitei18 – 181Heme (covalent)PROSITE-ProRule annotation1 Publication
Metal bindingi19 – 191Iron (heme axial ligand)
Metal bindingi81 – 811Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: GO_Central
  2. electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: Ensembl
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. apoptotic DNA fragmentation Source: Ensembl
  2. mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  3. mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
  4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_189537. Detoxification of Reactive Oxygen Species.
REACT_217196. Transcriptional activation of mitochondrial biogenesis.
REACT_231876. Formation of apoptosome.
REACT_252606. Activation of caspases through apoptosome-mediated cleavage.
REACT_259552. Release of apoptotic factors from the mitochondria.
REACT_259996. Respiratory electron transport.
REACT_269679. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrial intermembrane space Source: GO_Central
  3. nucleus Source: Ensembl
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 105104Cytochrome cPRO_0000108239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP67881.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037050.

Structurei

3D structure databases

ProteinModelPortaliP67881.
SMRiP67881. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP67881.
KOiK08738.
OMAiTWLKEST.
OrthoDBiEOG761BWX.
PhylomeDBiP67881.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDIEKGKKI FVQKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAEGFSYT
60 70 80 90 100
DANKNKGITW GEDTLMEYLE NPKKYIPGTK MIFAGIKKKS ERVDLIAYLK

DATSK
Length:105
Mass (Da):11,711
Last modified:January 23, 2007 - v2
Checksum:i293CEF5B11DABC36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02303 Genomic DNA. Translation: AAA48741.1.
X00230 Genomic DNA. Translation: CAA25046.1.
PIRiA00014. CCCH.
RefSeqiNP_001072946.1. NM_001079478.1.
UniGeneiGga.48682.

Genome annotation databases

EnsembliENSGALT00000017955; ENSGALP00000017934; ENSGALG00000011020.
GeneIDi420624.
KEGGigga:420624.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02303 Genomic DNA. Translation: AAA48741.1.
X00230 Genomic DNA. Translation: CAA25046.1.
PIRiA00014. CCCH.
RefSeqiNP_001072946.1. NM_001079478.1.
UniGeneiGga.48682.

3D structure databases

ProteinModelPortaliP67881.
SMRiP67881. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037050.

Proteomic databases

PaxDbiP67881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017955; ENSGALP00000017934; ENSGALG00000011020.
GeneIDi420624.
KEGGigga:420624.

Organism-specific databases

CTDi54205.

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP67881.
KOiK08738.
OMAiTWLKEST.
OrthoDBiEOG761BWX.
PhylomeDBiP67881.

Enzyme and pathway databases

ReactomeiREACT_189537. Detoxification of Reactive Oxygen Species.
REACT_217196. Transcriptional activation of mitochondrial biogenesis.
REACT_231876. Formation of apoptosome.
REACT_252606. Activation of caspases through apoptosome-mediated cleavage.
REACT_259552. Release of apoptotic factors from the mitochondria.
REACT_259996. Respiratory electron transport.
REACT_269679. Orphan transporters.

Miscellaneous databases

NextBioi20823511.
PROiP67881.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of two alleles of the chicken cytochrome c gene."
    Limbach K.J., Wu R.
    Nucleic Acids Res. 11:8931-8950(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Amino acid sequence of chicken heart cytochrome c."
    Chan S.K., Margoliash E.
    J. Biol. Chem. 241:507-515(1966) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.
    Tissue: Heart.

Entry informationi

Entry nameiCYC_CHICK
AccessioniPrimary (citable) accession number: P67881
Secondary accession number(s): P00016, Q9PRU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.