Casein kinase II subunit beta - Rattus norvegicus (Rat)

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P67874 (CSK2B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Casein kinase II subunit beta
Short name=CK II beta

Alternative name(s):
Phosvitin

Gene names

Name:	Csnk2b
Synonyms:	Ck2n

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit By similarity. Ref.3
Subunit structure	Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163 and TCTEX1D3. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Ref.3 Ref.4
Post-translational modification	Phosphorylated by alpha subunit. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity. Ref.3
Sequence similarities	Belongs to the casein kinase 2 subunit beta family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	I-kappaB kinase/NF-kappaB cascade Traceable author statement. Source: RGD Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of Wnt receptor signaling pathway Traceable author statement. Source: RGD
Cellular component	protein kinase CK2 complex Inferred from electronic annotation. Source: InterPro
Molecular function	protein kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 215

215

Casein kinase II subunit beta

PRO_0000068240

Regions

Region

188 – 193

Interaction with alpha subunit

Compositional bias

55 – 64

Asp/Glu-rich (acidic)

Sites

Metal binding

109

Zinc

Metal binding

114

Zinc

Metal binding

137

Zinc

Metal binding

140

Zinc

Amino acid modifications

Modified residue

Phosphoserine; by autocatalysis Probable

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

145

Phosphothreonine By similarity

Modified residue

197

Phosphotyrosine By similarity

Modified residue

205

Phosphoserine By similarity

Modified residue

209

Phosphoserine By similarity

Modified residue

212

N6-acetyllysine By similarity

Secondary structure

215

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P67874 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E465B1E699B0E0EC
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FASTA

215

24,942

        10         20         30         40         50         60 
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 

        70         80         90        100        110        120 
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 

       130        140        150        160        170        180 
PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 

       190        200        210 
NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate." Ahmed K., Davis A., Hanten J., Lambert D., McIvor R.S., Goueli S.A. Cell. Mol. Biol. Res. 39:451-462(1993) [PubMed: 8173590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed: 15060004] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[3]	"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction." Cheusova T., Khan M.A., Schubert S.W., Gavin A.C., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner H.R., Hashemolhosseini S. Genes Dev. 20:1800-1816(2006) [PubMed: 16818610] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF MUSK, INTERACTION WITH MUSK.
[4]	"Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2." Zhou W., Qin X., Yan X., Xie X., Li L., Fang S., Long J., Adelman J., Tang W.-J., Shen Y. Chin. Sci. Bull. 54:220-226(2009) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS), SUBUNIT, ZINC-BINDING SITES.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L15619 mRNA. Translation: AAA40928.1.
BX883045 Genomic DNA. Translation: CAE83994.1.

IPI

IPI00205531.

RefSeq

NP_001030315.1. NM_001035238.2.
NP_112283.1. NM_031021.3.

UniGene

Rn.137692.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2R6M	X-ray	3.10	A/B	1-215	[»]

ProteinModelPortal

P67874.

SMR

P67874. Positions 2-205.

ModBase

Search...

Protein-protein interaction databases

IntAct

P67874. 1 interaction.

STRING

P67874.

PTM databases

PhosphoSite

P67874.

Proteomic databases

PRIDE

P67874.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000001123; ENSRNOP00000001123; ENSRNOG00000000847.

GeneID

81650.

KEGG

rno:81650.

UCSC

NM_031021. rat.

Organism-specific databases

CTD

1460.

RGD

619978. Csnk2b.

Phylogenomic databases

eggNOG

maNOG15317.

HOVERGEN

HBG051131.

InParanoid

P67874.

OMA

TNQFVPR.

OrthoDB

EOG4FBHTQ.

PhylomeDB

P67874.

Gene expression databases

ArrayExpress

P67874.

Genevestigator

P67874.

GermOnline

ENSRNOG00000000847. Rattus norvegicus.

Family and domain databases

InterPro

IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]

Gene3D

G3DSA:1.10.1820.10. Casein_kin_II_reg-sub_a-hlx. 1 hit.
G3DSA:2.20.25.20. Casein_kin_II_reg-sub_b-sht. 1 hit.

K03115.

PANTHER

PTHR11740. CAS_kinase_II. 1 hit.

Pfam

PF01214. CK_II_beta. 1 hit.
[Graphical view]

PRINTS

PR00472. CASNKINASEII.

SMART

SM01085. CK_II_beta. 1 hit.
[Graphical view]

SUPFAM

SSF57798. Casein_kinase_II_reg-sub. 1 hit.

PROSITE

PS01101. CK2_BETA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

615182.

Entry information

Entry name

CSK2B_RAT

Accession

Primary (citable) accession number: P67874
Secondary accession number(s): P07312, P13862

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents