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Protein

Casein kinase II subunit beta

Gene

Csnk2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi137Zinc1
Metal bindingi140Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
R-RNO-201688. WNT mediated activation of DVL.
R-RNO-2514853. Condensation of Prometaphase Chromosomes.
R-RNO-445144. Signal transduction by L1.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Gene namesi
Name:Csnk2b
Synonyms:Ck2n
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi619978. Csnk2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000682402 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by autocatalysisCurated1
Modified residuei3Phosphoserine; by autocatalysisBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei212N6-acetyllysine; alternateBy similarity1
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylated by alpha subunit. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP67874.
PRIDEiP67874.

PTM databases

iPTMnetiP67874.
PhosphoSitePlusiP67874.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000847.
ExpressionAtlasiP67874. baseline and differential.
GenevisibleiP67874. RN.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163 and TCTEX1D3. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity). Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249550. 6 interactors.
IntActiP67874. 2 interactors.
STRINGi10116.ENSRNOP00000001123.

Chemistry databases

BindingDBiP67874.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 15Combined sources7
Helixi27 – 31Combined sources5
Helixi33 – 35Combined sources3
Turni37 – 42Combined sources6
Helixi46 – 53Combined sources8
Turni70 – 73Combined sources4
Helixi74 – 87Combined sources14
Helixi91 – 102Combined sources12
Turni103 – 106Combined sources4
Helixi112 – 114Combined sources3
Beta strandi120 – 122Combined sources3
Beta strandi126 – 130Combined sources5
Beta strandi134 – 137Combined sources4
Turni138 – 141Combined sources4
Beta strandi142 – 144Combined sources3
Beta strandi147 – 149Combined sources3
Helixi156 – 158Combined sources3
Helixi163 – 168Combined sources6
Helixi172 – 174Combined sources3
Beta strandi186 – 191Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R6MX-ray3.10A/B1-215[»]
ProteinModelPortaliP67874.
SMRiP67874.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67874.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 193Interaction with alpha subunit6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67874.
KOiK03115.
OMAiPRVNCSG.
OrthoDBiEOG091G0L2H.
PhylomeDBiP67874.
TreeFamiTF314462.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15619 mRNA. Translation: AAA40928.1.
BX883045 Genomic DNA. Translation: CAE83994.1.
RefSeqiNP_001030315.1. NM_001035238.2.
NP_112283.1. NM_031021.3.
UniGeneiRn.137692.

Genome annotation databases

EnsembliENSRNOT00000001123; ENSRNOP00000001123; ENSRNOG00000000847.
ENSRNOT00000076528; ENSRNOP00000068429; ENSRNOG00000000847.
GeneIDi81650.
KEGGirno:81650.
UCSCiRGD:619978. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15619 mRNA. Translation: AAA40928.1.
BX883045 Genomic DNA. Translation: CAE83994.1.
RefSeqiNP_001030315.1. NM_001035238.2.
NP_112283.1. NM_031021.3.
UniGeneiRn.137692.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R6MX-ray3.10A/B1-215[»]
ProteinModelPortaliP67874.
SMRiP67874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249550. 6 interactors.
IntActiP67874. 2 interactors.
STRINGi10116.ENSRNOP00000001123.

Chemistry databases

BindingDBiP67874.

PTM databases

iPTMnetiP67874.
PhosphoSitePlusiP67874.

Proteomic databases

PaxDbiP67874.
PRIDEiP67874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001123; ENSRNOP00000001123; ENSRNOG00000000847.
ENSRNOT00000076528; ENSRNOP00000068429; ENSRNOG00000000847.
GeneIDi81650.
KEGGirno:81650.
UCSCiRGD:619978. rat.

Organism-specific databases

CTDi1460.
RGDi619978. Csnk2b.

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67874.
KOiK03115.
OMAiPRVNCSG.
OrthoDBiEOG091G0L2H.
PhylomeDBiP67874.
TreeFamiTF314462.

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
R-RNO-201688. WNT mediated activation of DVL.
R-RNO-2514853. Condensation of Prometaphase Chromosomes.
R-RNO-445144. Signal transduction by L1.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

EvolutionaryTraceiP67874.
PROiP67874.

Gene expression databases

BgeeiENSRNOG00000000847.
ExpressionAtlasiP67874. baseline and differential.
GenevisibleiP67874. RN.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_RAT
AccessioniPrimary (citable) accession number: P67874
Secondary accession number(s): P07312, P13862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.