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Protein

Casein kinase II subunit beta

Gene

Csnk2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Participates in Wnt signaling.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi137ZincBy similarity1
Metal bindingi140ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-201688. WNT mediated activation of DVL.
R-MMU-2514853. Condensation of Prometaphase Chromosomes.
R-MMU-445144. Signal transduction by L1.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Gene namesi
Name:Csnk2b
Synonyms:Ck2n
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88548. Csnk2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000682372 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by autocatalysisCurated1
Modified residuei3Phosphoserine; by autocatalysisBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei212N6-acetyllysine; alternateBy similarity1
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP67871.
MaxQBiP67871.
PaxDbiP67871.
PRIDEiP67871.
TopDownProteomicsiP67871.

PTM databases

iPTMnetiP67871.
PhosphoSitePlusiP67871.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024387.
CleanExiMM_CSNK2B.
ExpressionAtlasiP67871. baseline and differential.
GenevisibleiP67871. MM.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity). Interacts with TCTEX1D3. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Tcte3P11985-22EBI-348179,EBI-1781298

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198947. 4 interactors.
DIPiDIP-35573N.
IntActiP67871. 10 interactors.
MINTiMINT-4153257.
STRINGi10090.ENSMUSP00000025246.

Structurei

3D structure databases

ProteinModelPortaliP67871.
SMRiP67871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 193Interaction with alpha subunitBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67871.
KOiK03115.
PhylomeDBiP67871.
TreeFamiTF314462.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52959 mRNA. Translation: CAA37132.1.
X56502 mRNA. Translation: CAA39857.1.
X80685 Genomic DNA. Translation: CAA56700.1.
AF109719 Genomic DNA. Translation: AAF03911.1.
AK002903 mRNA. Translation: BAB22445.1.
AK010730 mRNA. Translation: BAB27147.1.
AK012369 mRNA. Translation: BAB28193.1.
AK146186 mRNA. Translation: BAE26962.1.
AK161330 mRNA. Translation: BAE36328.1.
BC003775 mRNA. Translation: AAH03775.1.
CCDSiCCDS28684.1.
PIRiS14724.
RefSeqiNP_001290374.1. NM_001303445.1.
NP_034105.1. NM_009975.3.
UniGeneiMm.378901.

Genome annotation databases

EnsembliENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387.
ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387.
GeneIDi13001.
KEGGimmu:13001.
UCSCiuc008cfu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52959 mRNA. Translation: CAA37132.1.
X56502 mRNA. Translation: CAA39857.1.
X80685 Genomic DNA. Translation: CAA56700.1.
AF109719 Genomic DNA. Translation: AAF03911.1.
AK002903 mRNA. Translation: BAB22445.1.
AK010730 mRNA. Translation: BAB27147.1.
AK012369 mRNA. Translation: BAB28193.1.
AK146186 mRNA. Translation: BAE26962.1.
AK161330 mRNA. Translation: BAE36328.1.
BC003775 mRNA. Translation: AAH03775.1.
CCDSiCCDS28684.1.
PIRiS14724.
RefSeqiNP_001290374.1. NM_001303445.1.
NP_034105.1. NM_009975.3.
UniGeneiMm.378901.

3D structure databases

ProteinModelPortaliP67871.
SMRiP67871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198947. 4 interactors.
DIPiDIP-35573N.
IntActiP67871. 10 interactors.
MINTiMINT-4153257.
STRINGi10090.ENSMUSP00000025246.

Chemistry databases

ChEMBLiCHEMBL4095.

PTM databases

iPTMnetiP67871.
PhosphoSitePlusiP67871.

Proteomic databases

EPDiP67871.
MaxQBiP67871.
PaxDbiP67871.
PRIDEiP67871.
TopDownProteomicsiP67871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387.
ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387.
GeneIDi13001.
KEGGimmu:13001.
UCSCiuc008cfu.2. mouse.

Organism-specific databases

CTDi1460.
MGIiMGI:88548. Csnk2b.

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67871.
KOiK03115.
PhylomeDBiP67871.
TreeFamiTF314462.

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-201688. WNT mediated activation of DVL.
R-MMU-2514853. Condensation of Prometaphase Chromosomes.
R-MMU-445144. Signal transduction by L1.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP67871.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024387.
CleanExiMM_CSNK2B.
ExpressionAtlasiP67871. baseline and differential.
GenevisibleiP67871. MM.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_MOUSE
AccessioniPrimary (citable) accession number: P67871
Secondary accession number(s): P07312, P13862, Q3TTJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.