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P67871

- CSK2B_MOUSE

UniProt

P67871 - CSK2B_MOUSE

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Protein

Casein kinase II subunit beta

Gene

Csnk2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Participates in Wnt signaling.By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091ZincBy similarity
Metal bindingi114 – 1141ZincBy similarity
Metal bindingi137 – 1371ZincBy similarity
Metal bindingi140 – 1401ZincBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein kinase regulator activity Source: InterPro

GO - Biological processi

  1. adiponectin-activated signaling pathway Source: Ensembl
  2. endothelial tube morphogenesis Source: Ensembl
  3. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  4. positive regulation of activin receptor signaling pathway Source: Ensembl
  5. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  6. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.
REACT_215461. Signal transduction by L1.
REACT_225118. WNT mediated activation of DVL.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Gene namesi
Name:Csnk2b
Synonyms:Ck2n
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:88548. Csnk2b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. PcG protein complex Source: Ensembl
  4. plasma membrane Source: Ensembl
  5. protein kinase CK2 complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 215214Casein kinase II subunit betaPRO_0000068237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21Phosphoserine; by autocatalysisCurated
Modified residuei3 – 31Phosphoserine; by autocatalysisBy similarity
Modified residuei209 – 2091PhosphoserineBy similarity
Modified residuei212 – 2121N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP67871.
PaxDbiP67871.
PRIDEiP67871.

PTM databases

PhosphoSiteiP67871.

Expressioni

Gene expression databases

BgeeiP67871.
CleanExiMM_CSNK2B.
ExpressionAtlasiP67871. baseline and differential.
GenevestigatoriP67871.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity). Interacts with TCTEX1D3. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Tcte3P11985-22EBI-348179,EBI-1781298

Protein-protein interaction databases

BioGridi198947. 3 interactions.
IntActiP67871. 10 interactions.
MINTiMINT-4153257.

Structurei

3D structure databases

ProteinModelPortaliP67871.
SMRiP67871. Positions 7-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1936Interaction with alpha subunitBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 6410Asp/Glu-rich (acidic)

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5041.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67871.
KOiK03115.
OrthoDBiEOG7GTT4V.
PhylomeDBiP67871.
TreeFamiTF314462.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52959 mRNA. Translation: CAA37132.1.
X56502 mRNA. Translation: CAA39857.1.
X80685 Genomic DNA. Translation: CAA56700.1.
AF109719 Genomic DNA. Translation: AAF03911.1.
AK002903 mRNA. Translation: BAB22445.1.
AK010730 mRNA. Translation: BAB27147.1.
AK012369 mRNA. Translation: BAB28193.1.
AK146186 mRNA. Translation: BAE26962.1.
AK161330 mRNA. Translation: BAE36328.1.
BC003775 mRNA. Translation: AAH03775.1.
CCDSiCCDS28684.1.
PIRiS14724.
RefSeqiNP_034105.1. NM_009975.2.
XP_006523639.1. XM_006523576.1.
XP_006525361.1. XM_006525298.1.
XP_006536575.1. XM_006536512.1.
XP_006537308.1. XM_006537245.1.
UniGeneiMm.378901.

Genome annotation databases

EnsembliENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387.
ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387.
GeneIDi13001.
KEGGimmu:13001.
UCSCiuc008cfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52959 mRNA. Translation: CAA37132.1 .
X56502 mRNA. Translation: CAA39857.1 .
X80685 Genomic DNA. Translation: CAA56700.1 .
AF109719 Genomic DNA. Translation: AAF03911.1 .
AK002903 mRNA. Translation: BAB22445.1 .
AK010730 mRNA. Translation: BAB27147.1 .
AK012369 mRNA. Translation: BAB28193.1 .
AK146186 mRNA. Translation: BAE26962.1 .
AK161330 mRNA. Translation: BAE36328.1 .
BC003775 mRNA. Translation: AAH03775.1 .
CCDSi CCDS28684.1.
PIRi S14724.
RefSeqi NP_034105.1. NM_009975.2.
XP_006523639.1. XM_006523576.1.
XP_006525361.1. XM_006525298.1.
XP_006536575.1. XM_006536512.1.
XP_006537308.1. XM_006537245.1.
UniGenei Mm.378901.

3D structure databases

ProteinModelPortali P67871.
SMRi P67871. Positions 7-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198947. 3 interactions.
IntActi P67871. 10 interactions.
MINTi MINT-4153257.

Chemistry

BindingDBi P67871.
ChEMBLi CHEMBL4095.

PTM databases

PhosphoSitei P67871.

Proteomic databases

MaxQBi P67871.
PaxDbi P67871.
PRIDEi P67871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025246 ; ENSMUSP00000025246 ; ENSMUSG00000024387 .
ENSMUST00000173114 ; ENSMUSP00000134218 ; ENSMUSG00000024387 .
GeneIDi 13001.
KEGGi mmu:13001.
UCSCi uc008cfu.1. mouse.

Organism-specific databases

CTDi 1460.
MGIi MGI:88548. Csnk2b.

Phylogenomic databases

eggNOGi COG5041.
GeneTreei ENSGT00390000003781.
HOGENOMi HOG000039270.
HOVERGENi HBG051131.
InParanoidi P67871.
KOi K03115.
OrthoDBi EOG7GTT4V.
PhylomeDBi P67871.
TreeFami TF314462.

Enzyme and pathway databases

Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.
REACT_215461. Signal transduction by L1.
REACT_225118. WNT mediated activation of DVL.

Miscellaneous databases

NextBioi 282816.
PROi P67871.
SOURCEi Search...

Gene expression databases

Bgeei P67871.
CleanExi MM_CSNK2B.
ExpressionAtlasi P67871. baseline and differential.
Genevestigatori P67871.

Family and domain databases

Gene3Di 1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProi IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view ]
PANTHERi PTHR11740. PTHR11740. 1 hit.
Pfami PF01214. CK_II_beta. 1 hit.
[Graphical view ]
PRINTSi PR00472. CASNKINASEII.
SMARTi SM01085. CK_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF57798. SSF57798. 1 hit.
PROSITEi PS01101. CK2_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II."
    Kopatz I., Naiman T., Eli D., Canaani D.
    Nucleic Acids Res. 18:3639-3639(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The beta subunit of casein kinase II: cloning of cDNAs from murine and porcine origin and expression of the porcine sequence as a fusion protein."
    Boldyreff B., Piontek K., Schmidt-Spaniol I., Issinger O.-J.
    Biochim. Biophys. Acta 1088:439-441(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure of the gene encoding the murine protein kinase CK2 beta subunit."
    Boldyreff B., Issinger O.G.
    Genomics 29:253-256(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6 X CBA.
    Tissue: Spleen.
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Kidney and Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  7. "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells."
    Song D.H., Sussman D.J., Seldin D.C.
    J. Biol. Chem. 275:23790-23797(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN WNT SIGNALING.
  8. "The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis."
    Bai X., Xu X., Zhang F., Shu H.-B., Chan E.D.
    Biochem. Biophys. Res. Commun. 307:86-91(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCTEX1D3.
  9. "Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."
    Cheusova T., Khan M.A., Schubert S.W., Gavin A.C., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner H.R., Hashemolhosseini S.
    Genes Dev. 20:1800-1816(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF MUSK, INTERACTION WITH MUSK.

Entry informationi

Entry nameiCSK2B_MOUSE
AccessioniPrimary (citable) accession number: P67871
Secondary accession number(s): P07312, P13862, Q3TTJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3