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P67871

- CSK2B_MOUSE

UniProt

P67871 - CSK2B_MOUSE

Protein

Casein kinase II subunit beta

Gene

Csnk2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Plays a complex role in regulating the basal catalytic activity of the alpha subunit By similarity. Participates in Wnt signaling.By similarity2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091ZincBy similarity
    Metal bindingi114 – 1141ZincBy similarity
    Metal bindingi137 – 1371ZincBy similarity
    Metal bindingi140 – 1401ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein kinase regulator activity Source: InterPro

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: Ensembl
    2. endothelial tube morphogenesis Source: Ensembl
    3. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    4. positive regulation of activin receptor signaling pathway Source: Ensembl
    5. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    6. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.
    REACT_215461. Signal transduction by L1.
    REACT_225118. WNT mediated activation of DVL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase II subunit beta
    Short name:
    CK II beta
    Alternative name(s):
    Phosvitin
    Gene namesi
    Name:Csnk2b
    Synonyms:Ck2n
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:88548. Csnk2b.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. PcG protein complex Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. protein kinase CK2 complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 215214Casein kinase II subunit betaPRO_0000068237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei2 – 21Phosphoserine; by autocatalysisCurated
    Modified residuei3 – 31Phosphoserine; by autocatalysisBy similarity
    Modified residuei209 – 2091PhosphoserineBy similarity
    Modified residuei212 – 2121N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated by alpha subunit.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP67871.
    PaxDbiP67871.
    PRIDEiP67871.

    PTM databases

    PhosphoSiteiP67871.

    Expressioni

    Gene expression databases

    ArrayExpressiP67871.
    BgeeiP67871.
    CleanExiMM_CSNK2B.
    GenevestigatoriP67871.

    Interactioni

    Subunit structurei

    Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity. Interacts with TCTEX1D3. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tcte3P11985-22EBI-348179,EBI-1781298

    Protein-protein interaction databases

    BioGridi198947. 3 interactions.
    IntActiP67871. 10 interactions.
    MINTiMINT-4153257.

    Structurei

    3D structure databases

    ProteinModelPortaliP67871.
    SMRiP67871. Positions 7-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni188 – 1936Interaction with alpha subunitBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 6410Asp/Glu-rich (acidic)

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5041.
    GeneTreeiENSGT00390000003781.
    HOGENOMiHOG000039270.
    HOVERGENiHBG051131.
    InParanoidiP67871.
    KOiK03115.
    OrthoDBiEOG7GTT4V.
    PhylomeDBiP67871.
    TreeFamiTF314462.

    Family and domain databases

    Gene3Di1.10.1820.10. 1 hit.
    2.20.25.20. 1 hit.
    InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
    IPR016150. Casein_kin_II_reg-sub_b-sht.
    IPR000704. Casein_kinase_II_reg-sub.
    [Graphical view]
    PANTHERiPTHR11740. PTHR11740. 1 hit.
    PfamiPF01214. CK_II_beta. 1 hit.
    [Graphical view]
    PRINTSiPR00472. CASNKINASEII.
    SMARTiSM01085. CK_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF57798. SSF57798. 1 hit.
    PROSITEiPS01101. CK2_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P67871-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL    50
    DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK 100
    YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR 150
    HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ 200
    LQAASNFKSP VKTIR 215
    Length:215
    Mass (Da):24,942
    Last modified:October 11, 2004 - v1
    Checksum:iE465B1E699B0E0EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52959 mRNA. Translation: CAA37132.1.
    X56502 mRNA. Translation: CAA39857.1.
    X80685 Genomic DNA. Translation: CAA56700.1.
    AF109719 Genomic DNA. Translation: AAF03911.1.
    AK002903 mRNA. Translation: BAB22445.1.
    AK010730 mRNA. Translation: BAB27147.1.
    AK012369 mRNA. Translation: BAB28193.1.
    AK146186 mRNA. Translation: BAE26962.1.
    AK161330 mRNA. Translation: BAE36328.1.
    BC003775 mRNA. Translation: AAH03775.1.
    CCDSiCCDS28684.1.
    PIRiS14724.
    RefSeqiNP_034105.1. NM_009975.2.
    XP_006523639.1. XM_006523576.1.
    XP_006525361.1. XM_006525298.1.
    XP_006536575.1. XM_006536512.1.
    XP_006537308.1. XM_006537245.1.
    UniGeneiMm.378901.

    Genome annotation databases

    EnsembliENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387.
    ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387.
    GeneIDi13001.
    KEGGimmu:13001.
    UCSCiuc008cfu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52959 mRNA. Translation: CAA37132.1 .
    X56502 mRNA. Translation: CAA39857.1 .
    X80685 Genomic DNA. Translation: CAA56700.1 .
    AF109719 Genomic DNA. Translation: AAF03911.1 .
    AK002903 mRNA. Translation: BAB22445.1 .
    AK010730 mRNA. Translation: BAB27147.1 .
    AK012369 mRNA. Translation: BAB28193.1 .
    AK146186 mRNA. Translation: BAE26962.1 .
    AK161330 mRNA. Translation: BAE36328.1 .
    BC003775 mRNA. Translation: AAH03775.1 .
    CCDSi CCDS28684.1.
    PIRi S14724.
    RefSeqi NP_034105.1. NM_009975.2.
    XP_006523639.1. XM_006523576.1.
    XP_006525361.1. XM_006525298.1.
    XP_006536575.1. XM_006536512.1.
    XP_006537308.1. XM_006537245.1.
    UniGenei Mm.378901.

    3D structure databases

    ProteinModelPortali P67871.
    SMRi P67871. Positions 7-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198947. 3 interactions.
    IntActi P67871. 10 interactions.
    MINTi MINT-4153257.

    Chemistry

    BindingDBi P67871.
    ChEMBLi CHEMBL4095.

    PTM databases

    PhosphoSitei P67871.

    Proteomic databases

    MaxQBi P67871.
    PaxDbi P67871.
    PRIDEi P67871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025246 ; ENSMUSP00000025246 ; ENSMUSG00000024387 .
    ENSMUST00000173114 ; ENSMUSP00000134218 ; ENSMUSG00000024387 .
    GeneIDi 13001.
    KEGGi mmu:13001.
    UCSCi uc008cfu.1. mouse.

    Organism-specific databases

    CTDi 1460.
    MGIi MGI:88548. Csnk2b.

    Phylogenomic databases

    eggNOGi COG5041.
    GeneTreei ENSGT00390000003781.
    HOGENOMi HOG000039270.
    HOVERGENi HBG051131.
    InParanoidi P67871.
    KOi K03115.
    OrthoDBi EOG7GTT4V.
    PhylomeDBi P67871.
    TreeFami TF314462.

    Enzyme and pathway databases

    Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.
    REACT_215461. Signal transduction by L1.
    REACT_225118. WNT mediated activation of DVL.

    Miscellaneous databases

    NextBioi 282816.
    PROi P67871.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P67871.
    Bgeei P67871.
    CleanExi MM_CSNK2B.
    Genevestigatori P67871.

    Family and domain databases

    Gene3Di 1.10.1820.10. 1 hit.
    2.20.25.20. 1 hit.
    InterProi IPR016149. Casein_kin_II_reg-sub_a-hlx.
    IPR016150. Casein_kin_II_reg-sub_b-sht.
    IPR000704. Casein_kinase_II_reg-sub.
    [Graphical view ]
    PANTHERi PTHR11740. PTHR11740. 1 hit.
    Pfami PF01214. CK_II_beta. 1 hit.
    [Graphical view ]
    PRINTSi PR00472. CASNKINASEII.
    SMARTi SM01085. CK_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57798. SSF57798. 1 hit.
    PROSITEi PS01101. CK2_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II."
      Kopatz I., Naiman T., Eli D., Canaani D.
      Nucleic Acids Res. 18:3639-3639(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The beta subunit of casein kinase II: cloning of cDNAs from murine and porcine origin and expression of the porcine sequence as a fusion protein."
      Boldyreff B., Piontek K., Schmidt-Spaniol I., Issinger O.-J.
      Biochim. Biophys. Acta 1088:439-441(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure of the gene encoding the murine protein kinase CK2 beta subunit."
      Boldyreff B., Issinger O.G.
      Genomics 29:253-256(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6 X CBA.
      Tissue: Spleen.
    4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Kidney and Testis.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary tumor.
    7. "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells."
      Song D.H., Sussman D.J., Seldin D.C.
      J. Biol. Chem. 275:23790-23797(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN WNT SIGNALING.
    8. "The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis."
      Bai X., Xu X., Zhang F., Shu H.-B., Chan E.D.
      Biochem. Biophys. Res. Commun. 307:86-91(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TCTEX1D3.
    9. "Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."
      Cheusova T., Khan M.A., Schubert S.W., Gavin A.C., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner H.R., Hashemolhosseini S.
      Genes Dev. 20:1800-1816(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF MUSK, INTERACTION WITH MUSK.

    Entry informationi

    Entry nameiCSK2B_MOUSE
    AccessioniPrimary (citable) accession number: P67871
    Secondary accession number(s): P07312, P13862, Q3TTJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3