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P67871 (CSK2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Casein kinase II subunit beta

Short name=CK II beta
Alternative name(s):
Phosvitin
Gene names
Name:Csnk2b
Synonyms:Ck2n
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a complex role in regulating the basal catalytic activity of the alpha subunit By similarity. Participates in Wnt signaling. Ref.7 Ref.9

Subunit structure

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity. Interacts with TCTEX1D3. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 By similarity. Ref.8 Ref.9

Post-translational modification

Phosphorylated by alpha subunit By similarity.

Sequence similarities

Belongs to the casein kinase 2 subunit beta family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Tcte3P11985-22EBI-348179,EBI-1781298

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 215214Casein kinase II subunit beta
PRO_0000068237

Regions

Region188 – 1936Interaction with alpha subunit By similarity
Compositional bias55 – 6410Asp/Glu-rich (acidic)

Sites

Metal binding1091Zinc By similarity
Metal binding1141Zinc By similarity
Metal binding1371Zinc By similarity
Metal binding1401Zinc By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue21Phosphoserine; by autocatalysis Probable
Modified residue31Phosphoserine; by autocatalysis By similarity
Modified residue2091Phosphoserine By similarity
Modified residue2121N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P67871 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E465B1E699B0E0EC

FASTA21524,942
        10         20         30         40         50         60 
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 

        70         80         90        100        110        120 
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 

       130        140        150        160        170        180 
PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 

       190        200        210 
NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II."
Kopatz I., Naiman T., Eli D., Canaani D.
Nucleic Acids Res. 18:3639-3639(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The beta subunit of casein kinase II: cloning of cDNAs from murine and porcine origin and expression of the porcine sequence as a fusion protein."
Boldyreff B., Piontek K., Schmidt-Spaniol I., Issinger O.-J.
Biochim. Biophys. Acta 1088:439-441(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure of the gene encoding the murine protein kinase CK2 beta subunit."
Boldyreff B., Issinger O.G.
Genomics 29:253-256(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6 X CBA.
Tissue: Spleen.
[4]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and DBA/2.
Tissue: Kidney and Testis.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary tumor.
[7]"Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells."
Song D.H., Sussman D.J., Seldin D.C.
J. Biol. Chem. 275:23790-23797(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN WNT SIGNALING.
[8]"The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis."
Bai X., Xu X., Zhang F., Shu H.-B., Chan E.D.
Biochem. Biophys. Res. Commun. 307:86-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TCTEX1D3.
[9]"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."
Cheusova T., Khan M.A., Schubert S.W., Gavin A.C., Buchou T., Jacob G., Sticht H., Allende J., Boldyreff B., Brenner H.R., Hashemolhosseini S.
Genes Dev. 20:1800-1816(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN PHOSPHORYLATION OF MUSK, INTERACTION WITH MUSK.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52959 mRNA. Translation: CAA37132.1.
X56502 mRNA. Translation: CAA39857.1.
X80685 Genomic DNA. Translation: CAA56700.1.
AF109719 Genomic DNA. Translation: AAF03911.1.
AK002903 mRNA. Translation: BAB22445.1.
AK010730 mRNA. Translation: BAB27147.1.
AK012369 mRNA. Translation: BAB28193.1.
AK146186 mRNA. Translation: BAE26962.1.
AK161330 mRNA. Translation: BAE36328.1.
BC003775 mRNA. Translation: AAH03775.1.
CCDSCCDS28684.1.
PIRS14724.
RefSeqNP_034105.1. NM_009975.2.
XP_006523639.1. XM_006523576.1.
XP_006525361.1. XM_006525298.1.
XP_006536575.1. XM_006536512.1.
XP_006537308.1. XM_006537245.1.
UniGeneMm.378901.

3D structure databases

ProteinModelPortalP67871.
SMRP67871. Positions 7-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198947. 3 interactions.
IntActP67871. 10 interactions.
MINTMINT-4153257.

Chemistry

BindingDBP67871.
ChEMBLCHEMBL4095.

PTM databases

PhosphoSiteP67871.

Proteomic databases

MaxQBP67871.
PaxDbP67871.
PRIDEP67871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387.
ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387.
GeneID13001.
KEGGmmu:13001.
UCSCuc008cfu.1. mouse.

Organism-specific databases

CTD1460.
MGIMGI:88548. Csnk2b.

Phylogenomic databases

eggNOGCOG5041.
GeneTreeENSGT00390000003781.
HOGENOMHOG000039270.
HOVERGENHBG051131.
InParanoidP67871.
KOK03115.
OrthoDBEOG7GTT4V.
PhylomeDBP67871.
TreeFamTF314462.

Gene expression databases

ArrayExpressP67871.
BgeeP67871.
CleanExMM_CSNK2B.
GenevestigatorP67871.

Family and domain databases

Gene3D1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERPTHR11740. PTHR11740. 1 hit.
PfamPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSPR00472. CASNKINASEII.
SMARTSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF57798. SSF57798. 1 hit.
PROSITEPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282816.
PROP67871.
SOURCESearch...

Entry information

Entry nameCSK2B_MOUSE
AccessionPrimary (citable) accession number: P67871
Secondary accession number(s): P07312, P13862, Q3TTJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot