Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase II subunit beta

Gene

Csnk2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Participates in Wnt signaling.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi137ZincBy similarity1
Metal bindingi140ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Gene namesi
Name:Csnk2b
Synonyms:Ck2n
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88548 Csnk2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000682372 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by autocatalysisBy similarityCurated1
Modified residuei3Phosphoserine; by autocatalysisBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei212N6-acetyllysine; alternateBy similarity1
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP67871
MaxQBiP67871
PaxDbiP67871
PRIDEiP67871
TopDownProteomicsiP67871

PTM databases

iPTMnetiP67871
PhosphoSitePlusiP67871

Expressioni

Gene expression databases

BgeeiENSMUSG00000024387
CleanExiMM_CSNK2B
ExpressionAtlasiP67871 baseline and differential
GenevisibleiP67871 MM

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity). Interacts with TCTEX1D3. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198947, 5 interactors
CORUMiP67871
DIPiDIP-35573N
IntActiP67871, 14 interactors
MINTiP67871
STRINGi10090.ENSMUSP00000025246

Structurei

3D structure databases

ProteinModelPortaliP67871
SMRiP67871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 193Interaction with alpha subunitBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092 Eukaryota
COG5041 LUCA
GeneTreeiENSGT00390000003781
HOGENOMiHOG000039270
HOVERGENiHBG051131
InParanoidiP67871
KOiK03115
PhylomeDBiP67871
TreeFamiTF314462

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub
PANTHERiPTHR11740 PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214 CK_II_beta, 1 hit
PRINTSiPR00472 CASNKINASEII
SMARTiView protein in SMART
SM01085 CK_II_beta, 1 hit
SUPFAMiSSF57798 SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101 CK2_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52959 mRNA Translation: CAA37132.1
X56502 mRNA Translation: CAA39857.1
X80685 Genomic DNA Translation: CAA56700.1
AF109719 Genomic DNA Translation: AAF03911.1
AK002903 mRNA Translation: BAB22445.1
AK010730 mRNA Translation: BAB27147.1
AK012369 mRNA Translation: BAB28193.1
AK146186 mRNA Translation: BAE26962.1
AK161330 mRNA Translation: BAE36328.1
BC003775 mRNA Translation: AAH03775.1
CCDSiCCDS28684.1
PIRiS14724
RefSeqiNP_001290374.1, NM_001303445.1
NP_034105.1, NM_009975.3
UniGeneiMm.378901

Genome annotation databases

EnsembliENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387
ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387
GeneIDi13001
KEGGimmu:13001
UCSCiuc008cfu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCSK2B_MOUSE
AccessioniPrimary (citable) accession number: P67871
Secondary accession number(s): P07312, P13862, Q3TTJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health