UniProtKB - P67870 (CSK2B_HUMAN)
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Protein
Casein kinase II subunit beta
Gene
CSNK2B
Organism
Homo sapiens (Human)
Status
Functioni
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 109 | Zinc | 1 | |
Metal bindingi | 114 | Zinc | 1 | |
Metal bindingi | 137 | Zinc | 1 | |
Metal bindingi | 140 | Zinc | 1 |
GO - Molecular functioni
- chromatin binding Source: MGI
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- protein domain specific binding Source: UniProtKB
- protein kinase regulator activity Source: UniProtKB
- protein serine/threonine kinase activity Source: CAFA
- receptor binding Source: BHF-UCL
- ribonucleoprotein complex binding Source: Ensembl
- transcription factor binding Source: BHF-UCL
GO - Biological processi
- adiponectin-activated signaling pathway Source: BHF-UCL
- cellular protein complex assembly Source: BHF-UCL
- endothelial tube morphogenesis Source: BHF-UCL
- liver regeneration Source: Ensembl
- macroautophagy Source: Reactome
- negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
- negative regulation of cell proliferation Source: BHF-UCL
- neutrophil degranulation Source: Reactome
- peptidyl-threonine phosphorylation Source: CAFA
- phosphatidylcholine biosynthetic process Source: Reactome
- positive regulation of activin receptor signaling pathway Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- protein folding Source: Reactome
- regulation of DNA binding Source: BHF-UCL
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to testosterone Source: Ensembl
- signal transduction Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-1483191. Synthesis of PC. R-HSA-201688. WNT mediated activation of DVL. R-HSA-2514853. Condensation of Prometaphase Chromosomes. R-HSA-445144. Signal transduction by L1. R-HSA-6798695. Neutrophil degranulation. R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation. R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding. R-HSA-8934903. Receptor Mediated Mitophagy. R-HSA-8939243. RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known. R-HSA-8948751. Regulation of PTEN stability and activity. |
SignaLinki | P67870. |
SIGNORi | P67870. |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaShort name: CK II beta Alternative name(s): Phosvitin Protein G5a |
Gene namesi | Name:CSNK2B Synonyms:CK2N, G5A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204435.13. |
HGNCi | HGNC:2460. CSNK2B. |
MIMi | 115441. gene. |
neXtProti | NX_P67870. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1460. |
OpenTargetsi | ENSG00000204435. |
PharmGKBi | PA26960. |
Chemistry databases
ChEMBLi | CHEMBL2358. |
Polymorphism and mutation databases
DMDMi | 54037520. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000068236 | 2 – 215 | Casein kinase II subunit betaAdd BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 3 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 37 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 69 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 212 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 212 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources |
Post-translational modificationi
Phosphorylated by alpha subunit.2 Publications
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P67870. |
MaxQBi | P67870. |
PaxDbi | P67870. |
PeptideAtlasi | P67870. |
PRIDEi | P67870. |
PTM databases
iPTMneti | P67870. |
PhosphoSitePlusi | P67870. |
Expressioni
Gene expression databases
Bgeei | ENSG00000204435. |
CleanExi | HS_CSNK2B. |
ExpressionAtlasi | P67870. baseline and differential. |
Genevisiblei | P67870. HS. |
Organism-specific databases
HPAi | CAB004349. CAB013087. CAB016059. HPA005944. |
Interactioni
Subunit structurei
Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein domain specific binding Source: UniProtKB
- receptor binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 107843. 323 interactors. |
CORUMi | P67870. |
DIPi | DIP-131N. |
IntActi | P67870. 217 interactors. |
MINTi | P67870. |
STRINGi | 9606.ENSP00000365025. |
Chemistry databases
BindingDBi | P67870. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 9 – 15 | Combined sources | 7 | |
Turni | 17 – 20 | Combined sources | 4 | |
Helixi | 27 – 31 | Combined sources | 5 | |
Helixi | 33 – 36 | Combined sources | 4 | |
Helixi | 39 – 41 | Combined sources | 3 | |
Beta strandi | 43 – 45 | Combined sources | 3 | |
Helixi | 46 – 53 | Combined sources | 8 | |
Beta strandi | 59 – 61 | Combined sources | 3 | |
Helixi | 67 – 87 | Combined sources | 21 | |
Helixi | 91 – 102 | Combined sources | 12 | |
Turni | 103 – 106 | Combined sources | 4 | |
Helixi | 112 – 114 | Combined sources | 3 | |
Beta strandi | 120 – 122 | Combined sources | 3 | |
Beta strandi | 134 – 136 | Combined sources | 3 | |
Turni | 138 – 140 | Combined sources | 3 | |
Beta strandi | 142 – 144 | Combined sources | 3 | |
Helixi | 149 – 151 | Combined sources | 3 | |
Beta strandi | 152 – 155 | Combined sources | 4 | |
Helixi | 156 – 158 | Combined sources | 3 | |
Turni | 159 – 162 | Combined sources | 4 | |
Helixi | 163 – 170 | Combined sources | 8 | |
Helixi | 172 – 174 | Combined sources | 3 | |
Beta strandi | 187 – 189 | Combined sources | 3 | |
Beta strandi | 190 – 192 | Combined sources | 3 | |
Helixi | 195 – 198 | Combined sources | 4 | |
Turni | 199 – 201 | Combined sources | 3 | |
Helixi | 202 – 205 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DS5 | X-ray | 3.16 | E/F/G/H | 181-203 | [»] | |
1JWH | X-ray | 3.10 | C/D | 1-215 | [»] | |
1QF8 | X-ray | 1.74 | A/B | 1-182 | [»] | |
3EED | X-ray | 2.80 | A/B | 1-193 | [»] | |
4DGL | X-ray | 3.00 | A/B | 1-215 | [»] | |
4MD7 | X-ray | 3.10 | A/B/C/D | 1-215 | [»] | |
4MD8 | X-ray | 3.30 | A/B/C/D | 1-215 | [»] | |
4MD9 | X-ray | 3.50 | A/B/C/D/I/J/N/O | 1-215 | [»] | |
4NH1 | X-ray | 3.30 | C/D | 1-215 | [»] | |
ProteinModelPortali | P67870. | |||||
SMRi | P67870. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P67870. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 193 | Interaction with alpha subunitBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 64 | Asp/Glu-rich (acidic) | 10 |
Sequence similaritiesi
Belongs to the casein kinase 2 subunit beta family.Curated
Phylogenomic databases
eggNOGi | KOG3092. Eukaryota. COG5041. LUCA. |
GeneTreei | ENSGT00390000003781. |
HOGENOMi | HOG000039270. |
HOVERGENi | HBG051131. |
InParanoidi | P67870. |
KOi | K03115. |
PhylomeDBi | P67870. |
TreeFami | TF314462. |
Family and domain databases
Gene3Di | 1.10.1820.10. 1 hit. |
InterProi | View protein in InterPro IPR016149. Casein_kin_II_reg-sub_N. IPR035991. Casein_kinase_II_beta_like. IPR000704. Casein_kinase_II_reg-sub. |
PANTHERi | PTHR11740. PTHR11740. 1 hit. |
Pfami | View protein in Pfam PF01214. CK_II_beta. 1 hit. |
PRINTSi | PR00472. CASNKINASEII. |
SMARTi | View protein in SMART SM01085. CK_II_beta. 1 hit. |
SUPFAMi | SSF57798. SSF57798. 1 hit. |
PROSITEi | View protein in PROSITE PS01101. CK2_BETA. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P67870-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Sequence cautioni
The sequence CAI18393 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 194 | P → A in AAA52123 (PubMed:2513884).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16937 mRNA. Translation: CAA34811.1. X16312 mRNA. Translation: CAA34379.1. M30448 mRNA. Translation: AAA52123.1. X57152 Genomic DNA. Translation: CAA40442.1. AY113186 mRNA. Translation: AAM50092.1. CR541699 mRNA. Translation: CAG46500.1. AF129756 Genomic DNA. Translation: AAD18081.1. BA000025 Genomic DNA. Translation: BAB63386.1. DQ314868 Genomic DNA. Translation: ABC40727.1. AK311860 mRNA. Translation: BAG34801.1. AL662899 Genomic DNA. Translation: CAI96141.1. AL662899 Genomic DNA. Translation: CAI18393.2. Different initiation. AL670886 Genomic DNA. Translation: CAI17800.1. AL805934 Genomic DNA. Translation: CAI18523.1. BX511262 Genomic DNA. Translation: CAM45825.1. CR753842 Genomic DNA. Translation: CAQ06572.1. CR354443 Genomic DNA. Translation: CAQ07002.1. CR759761 Genomic DNA. Translation: CAQ10879.1. CH471081 Genomic DNA. Translation: EAX03473.1. BC112017 mRNA. Translation: AAI12018.1. BC112019 mRNA. Translation: AAI12020.1. |
CCDSi | CCDS4712.1. |
PIRi | A39459. |
RefSeqi | NP_001269314.1. NM_001282385.1. NP_001311.3. NM_001320.6. |
UniGenei | Hs.73527. |
Genome annotation databases
Similar proteinsi
Entry informationi
Entry namei | CSK2B_HUMAN | |
Accessioni | P67870Primary (citable) accession number: P67870 Secondary accession number(s): B0UXA9 Q4VX47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | March 28, 2018 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |