Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase II subunit beta

Gene

CSNK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi137Zinc1
Metal bindingi140Zinc1

GO - Molecular functioni

  • chromatin binding Source: MGI
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: UniProtKB
  • protein kinase regulator activity Source: UniProtKB
  • receptor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • adiponectin-activated signaling pathway Source: BHF-UCL
  • cellular protein complex assembly Source: BHF-UCL
  • endothelial tube morphogenesis Source: BHF-UCL
  • negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • positive regulation of activin receptor signaling pathway Source: BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • protein folding Source: Reactome
  • protein phosphorylation Source: GOC
  • regulation of DNA binding Source: BHF-UCL
  • regulation of protein serine/threonine phosphatase activity Source: GO_Central
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • signal transduction Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111968-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-201688. WNT mediated activation of DVL.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-445144. Signal transduction by L1.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP67870.
SIGNORiP67870.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Protein G5a
Gene namesi
Name:CSNK2B
Synonyms:CK2N, G5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2460. CSNK2B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • protein kinase CK2 complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1460.
OpenTargetsiENSG00000204435.
ENSG00000206406.
ENSG00000224398.
ENSG00000224774.
ENSG00000228875.
ENSG00000230700.
ENSG00000232960.
PharmGKBiPA26960.

Chemistry databases

ChEMBLiCHEMBL2358.

Polymorphism and mutation databases

DMDMi54037520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000682362 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2Phosphoserine; by autocatalysis1 Publication1
Modified residuei3Phosphoserine; by autocatalysis1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212N6-acetyllysine; alternateCombined sources1
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationi

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP67870.
MaxQBiP67870.
PaxDbiP67870.
PeptideAtlasiP67870.
PRIDEiP67870.

PTM databases

iPTMnetiP67870.
PhosphoSitePlusiP67870.

Expressioni

Gene expression databases

BgeeiENSG00000204435.
CleanExiHS_CSNK2B.
ExpressionAtlasiP67870. baseline and differential.
GenevisibleiP67870. HS.

Organism-specific databases

HPAiCAB004349.
CAB013087.
CAB016059.
HPA005944.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-348169,EBI-348169
CACNA1AO005552EBI-348169,EBI-766279
CBX4O00257-32EBI-348169,EBI-4392727
Clip1Q9JK252EBI-348169,EBI-908338From a different organism.
ClockO087852EBI-348169,EBI-79859From a different organism.
CSNK2A1P6840017EBI-348169,EBI-347804
CSNK2A2P197848EBI-348169,EBI-347451
PACS1Q6VY073EBI-348169,EBI-2555014
RNF2Q994962EBI-348169,EBI-722416
SIRT1Q96EB65EBI-348169,EBI-1802965

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: UniProtKB
  • receptor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107843. 266 interactors.
DIPiDIP-131N.
IntActiP67870. 197 interactors.
MINTiMINT-88683.
STRINGi9606.ENSP00000365025.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 15Combined sources7
Turni17 – 20Combined sources4
Helixi27 – 31Combined sources5
Helixi33 – 36Combined sources4
Helixi39 – 41Combined sources3
Beta strandi43 – 45Combined sources3
Helixi46 – 53Combined sources8
Beta strandi59 – 61Combined sources3
Helixi67 – 87Combined sources21
Helixi91 – 102Combined sources12
Turni103 – 106Combined sources4
Helixi112 – 114Combined sources3
Beta strandi120 – 122Combined sources3
Beta strandi134 – 136Combined sources3
Turni138 – 140Combined sources3
Beta strandi142 – 144Combined sources3
Helixi149 – 151Combined sources3
Beta strandi152 – 155Combined sources4
Helixi156 – 158Combined sources3
Turni159 – 162Combined sources4
Helixi163 – 170Combined sources8
Helixi172 – 174Combined sources3
Beta strandi187 – 189Combined sources3
Beta strandi190 – 192Combined sources3
Helixi195 – 198Combined sources4
Turni199 – 201Combined sources3
Helixi202 – 205Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870.
SMRiP67870.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67870.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 193Interaction with alpha subunitBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67870.
KOiK03115.
PhylomeDBiP67870.
TreeFamiTF314462.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence cautioni

The sequence CAI18393 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194P → A in AAA52123 (PubMed:2513884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA. Translation: CAA34811.1.
X16312 mRNA. Translation: CAA34379.1.
M30448 mRNA. Translation: AAA52123.1.
X57152 Genomic DNA. Translation: CAA40442.1.
AY113186 mRNA. Translation: AAM50092.1.
CR541699 mRNA. Translation: CAG46500.1.
AF129756 Genomic DNA. Translation: AAD18081.1.
BA000025 Genomic DNA. Translation: BAB63386.1.
DQ314868 Genomic DNA. Translation: ABC40727.1.
AK311860 mRNA. Translation: BAG34801.1.
AL662899 Genomic DNA. Translation: CAI96141.1.
AL662899 Genomic DNA. Translation: CAI18393.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17800.1.
AL805934 Genomic DNA. Translation: CAI18523.1.
BX511262 Genomic DNA. Translation: CAM45825.1.
CR753842 Genomic DNA. Translation: CAQ06572.1.
CR354443 Genomic DNA. Translation: CAQ07002.1.
CR759761 Genomic DNA. Translation: CAQ10879.1.
CH471081 Genomic DNA. Translation: EAX03473.1.
BC112017 mRNA. Translation: AAI12018.1.
BC112019 mRNA. Translation: AAI12020.1.
CCDSiCCDS4712.1.
PIRiA39459.
RefSeqiNP_001269314.1. NM_001282385.1.
NP_001311.3. NM_001320.6.
UniGeneiHs.73527.

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435.
ENST00000375866; ENSP00000365026; ENSG00000204435.
ENST00000375882; ENSP00000365042; ENSG00000204435.
ENST00000383427; ENSP00000372919; ENSG00000206406.
ENST00000383433; ENSP00000372925; ENSG00000206406.
ENST00000400110; ENSP00000382980; ENSG00000206406.
ENST00000412802; ENSP00000413469; ENSG00000224774.
ENST00000418230; ENSP00000411322; ENSG00000228875.
ENST00000422567; ENSP00000407018; ENSG00000224398.
ENST00000429633; ENSP00000409510; ENSG00000230700.
ENST00000431476; ENSP00000394855; ENSG00000224398.
ENST00000436169; ENSP00000412520; ENSG00000224398.
ENST00000443673; ENSP00000400188; ENSG00000230700.
ENST00000448596; ENSP00000391038; ENSG00000232960.
ENST00000451917; ENSP00000415303; ENSG00000224774.
ENST00000452985; ENSP00000415237; ENSG00000228875.
ENST00000453234; ENSP00000395275; ENSG00000224774.
ENST00000454382; ENSP00000390900; ENSG00000232960.
ENST00000454511; ENSP00000393756; ENSG00000232960.
ENST00000455161; ENSP00000407379; ENSG00000230700.
ENST00000458330; ENSP00000410802; ENSG00000228875.
GeneIDi1460.
KEGGihsa:1460.
UCSCiuc003nvr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA. Translation: CAA34811.1.
X16312 mRNA. Translation: CAA34379.1.
M30448 mRNA. Translation: AAA52123.1.
X57152 Genomic DNA. Translation: CAA40442.1.
AY113186 mRNA. Translation: AAM50092.1.
CR541699 mRNA. Translation: CAG46500.1.
AF129756 Genomic DNA. Translation: AAD18081.1.
BA000025 Genomic DNA. Translation: BAB63386.1.
DQ314868 Genomic DNA. Translation: ABC40727.1.
AK311860 mRNA. Translation: BAG34801.1.
AL662899 Genomic DNA. Translation: CAI96141.1.
AL662899 Genomic DNA. Translation: CAI18393.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17800.1.
AL805934 Genomic DNA. Translation: CAI18523.1.
BX511262 Genomic DNA. Translation: CAM45825.1.
CR753842 Genomic DNA. Translation: CAQ06572.1.
CR354443 Genomic DNA. Translation: CAQ07002.1.
CR759761 Genomic DNA. Translation: CAQ10879.1.
CH471081 Genomic DNA. Translation: EAX03473.1.
BC112017 mRNA. Translation: AAI12018.1.
BC112019 mRNA. Translation: AAI12020.1.
CCDSiCCDS4712.1.
PIRiA39459.
RefSeqiNP_001269314.1. NM_001282385.1.
NP_001311.3. NM_001320.6.
UniGeneiHs.73527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870.
SMRiP67870.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107843. 266 interactors.
DIPiDIP-131N.
IntActiP67870. 197 interactors.
MINTiMINT-88683.
STRINGi9606.ENSP00000365025.

Chemistry databases

ChEMBLiCHEMBL2358.

PTM databases

iPTMnetiP67870.
PhosphoSitePlusiP67870.

Polymorphism and mutation databases

DMDMi54037520.

Proteomic databases

EPDiP67870.
MaxQBiP67870.
PaxDbiP67870.
PeptideAtlasiP67870.
PRIDEiP67870.

Protocols and materials databases

DNASUi1460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435.
ENST00000375866; ENSP00000365026; ENSG00000204435.
ENST00000375882; ENSP00000365042; ENSG00000204435.
ENST00000383427; ENSP00000372919; ENSG00000206406.
ENST00000383433; ENSP00000372925; ENSG00000206406.
ENST00000400110; ENSP00000382980; ENSG00000206406.
ENST00000412802; ENSP00000413469; ENSG00000224774.
ENST00000418230; ENSP00000411322; ENSG00000228875.
ENST00000422567; ENSP00000407018; ENSG00000224398.
ENST00000429633; ENSP00000409510; ENSG00000230700.
ENST00000431476; ENSP00000394855; ENSG00000224398.
ENST00000436169; ENSP00000412520; ENSG00000224398.
ENST00000443673; ENSP00000400188; ENSG00000230700.
ENST00000448596; ENSP00000391038; ENSG00000232960.
ENST00000451917; ENSP00000415303; ENSG00000224774.
ENST00000452985; ENSP00000415237; ENSG00000228875.
ENST00000453234; ENSP00000395275; ENSG00000224774.
ENST00000454382; ENSP00000390900; ENSG00000232960.
ENST00000454511; ENSP00000393756; ENSG00000232960.
ENST00000455161; ENSP00000407379; ENSG00000230700.
ENST00000458330; ENSP00000410802; ENSG00000228875.
GeneIDi1460.
KEGGihsa:1460.
UCSCiuc003nvr.3. human.

Organism-specific databases

CTDi1460.
DisGeNETi1460.
GeneCardsiCSNK2B.
HGNCiHGNC:2460. CSNK2B.
HPAiCAB004349.
CAB013087.
CAB016059.
HPA005944.
MIMi115441. gene.
neXtProtiNX_P67870.
OpenTargetsiENSG00000204435.
ENSG00000206406.
ENSG00000224398.
ENSG00000224774.
ENSG00000228875.
ENSG00000230700.
ENSG00000232960.
PharmGKBiPA26960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67870.
KOiK03115.
PhylomeDBiP67870.
TreeFamiTF314462.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111968-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-201688. WNT mediated activation of DVL.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-445144. Signal transduction by L1.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP67870.
SIGNORiP67870.

Miscellaneous databases

EvolutionaryTraceiP67870.
GeneWikiiCSNK2B.
GenomeRNAii1460.
PROiP67870.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204435.
CleanExiHS_CSNK2B.
ExpressionAtlasiP67870. baseline and differential.
GenevisibleiP67870. HS.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_HUMAN
AccessioniPrimary (citable) accession number: P67870
Secondary accession number(s): B0UXA9
, P07312, P13862, Q4VX47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.