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Protein

Casein kinase II subunit beta

Gene

CSNK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Zinc
Metal bindingi114 – 1141Zinc
Metal bindingi137 – 1371Zinc
Metal bindingi140 – 1401Zinc

GO - Molecular functioni

  • chromatin binding Source: MGI
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: UniProtKB
  • protein kinase regulator activity Source: UniProtKB
  • receptor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • adiponectin-activated signaling pathway Source: BHF-UCL
  • cellular protein complex assembly Source: BHF-UCL
  • endothelial tube morphogenesis Source: BHF-UCL
  • negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • positive regulation of activin receptor signaling pathway Source: BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • protein folding Source: Reactome
  • protein phosphorylation Source: GOC
  • regulation of DNA binding Source: BHF-UCL
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • signal transduction Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-201688. WNT mediated activation of DVL.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-445144. Signal transduction by L1.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP67870.
SIGNORiP67870.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Protein G5a
Gene namesi
Name:CSNK2B
Synonyms:CK2N, G5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2460. CSNK2B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • protein kinase CK2 complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26960.

Chemistry

ChEMBLiCHEMBL2095191.

Polymorphism and mutation databases

DMDMi54037520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 215214Casein kinase II subunit betaPRO_0000068236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei2 – 21Phosphoserine; by autocatalysis1 Publication
Modified residuei3 – 31Phosphoserine; by autocatalysis1 Publication
Modified residuei8 – 81PhosphoserineCombined sources
Modified residuei37 – 371PhosphothreonineCombined sources
Modified residuei69 – 691PhosphoserineCombined sources
Modified residuei209 – 2091PhosphoserineCombined sources
Modified residuei212 – 2121N6-acetyllysine; alternateCombined sources
Cross-linki212 – 212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationi

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP67870.
MaxQBiP67870.
PaxDbiP67870.
PeptideAtlasiP67870.
PRIDEiP67870.

PTM databases

iPTMnetiP67870.
PhosphoSiteiP67870.

Expressioni

Gene expression databases

BgeeiENSG00000204435.
CleanExiHS_CSNK2B.
ExpressionAtlasiP67870. baseline and differential.
GenevisibleiP67870. HS.

Organism-specific databases

HPAiCAB004349.
CAB013087.
CAB016059.
HPA005944.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-348169,EBI-348169
CACNA1AO005552EBI-348169,EBI-766279
CBX4O00257-32EBI-348169,EBI-4392727
Clip1Q9JK252EBI-348169,EBI-908338From a different organism.
ClockO087852EBI-348169,EBI-79859From a different organism.
CSNK2A1P6840016EBI-348169,EBI-347804
CSNK2A2P197847EBI-348169,EBI-347451
PACS1Q6VY073EBI-348169,EBI-2555014
SIRT1Q96EB65EBI-348169,EBI-1802965

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: UniProtKB
  • receptor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107843. 266 interactions.
DIPiDIP-131N.
IntActiP67870. 190 interactions.
MINTiMINT-88683.
STRINGi9606.ENSP00000365025.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 157Combined sources
Turni17 – 204Combined sources
Helixi27 – 315Combined sources
Helixi33 – 364Combined sources
Helixi39 – 413Combined sources
Beta strandi43 – 453Combined sources
Helixi46 – 538Combined sources
Beta strandi59 – 613Combined sources
Helixi67 – 8721Combined sources
Helixi91 – 10212Combined sources
Turni103 – 1064Combined sources
Helixi112 – 1143Combined sources
Beta strandi120 – 1223Combined sources
Beta strandi134 – 1363Combined sources
Turni138 – 1403Combined sources
Beta strandi142 – 1443Combined sources
Helixi149 – 1513Combined sources
Beta strandi152 – 1554Combined sources
Helixi156 – 1583Combined sources
Turni159 – 1624Combined sources
Helixi163 – 1708Combined sources
Helixi172 – 1743Combined sources
Beta strandi187 – 1893Combined sources
Beta strandi190 – 1923Combined sources
Helixi195 – 1984Combined sources
Turni199 – 2013Combined sources
Helixi202 – 2054Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870.
SMRiP67870. Positions 7-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67870.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1936Interaction with alpha subunitBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 6410Asp/Glu-rich (acidic)

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67870.
KOiK03115.
PhylomeDBiP67870.
TreeFamiTF314462.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Sequence cautioni

The sequence CAI18393 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941P → A in AAA52123 (PubMed:2513884).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA. Translation: CAA34811.1.
X16312 mRNA. Translation: CAA34379.1.
M30448 mRNA. Translation: AAA52123.1.
X57152 Genomic DNA. Translation: CAA40442.1.
AY113186 mRNA. Translation: AAM50092.1.
CR541699 mRNA. Translation: CAG46500.1.
AF129756 Genomic DNA. Translation: AAD18081.1.
BA000025 Genomic DNA. Translation: BAB63386.1.
DQ314868 Genomic DNA. Translation: ABC40727.1.
AK311860 mRNA. Translation: BAG34801.1.
AL662899 Genomic DNA. Translation: CAI96141.1.
AL662899 Genomic DNA. Translation: CAI18393.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17800.1.
AL805934 Genomic DNA. Translation: CAI18523.1.
BX511262 Genomic DNA. Translation: CAM45825.1.
CR753842 Genomic DNA. Translation: CAQ06572.1.
CR354443 Genomic DNA. Translation: CAQ07002.1.
CR759761 Genomic DNA. Translation: CAQ10879.1.
CH471081 Genomic DNA. Translation: EAX03473.1.
BC112017 mRNA. Translation: AAI12018.1.
BC112019 mRNA. Translation: AAI12020.1.
CCDSiCCDS4712.1.
PIRiA39459.
RefSeqiNP_001269314.1. NM_001282385.1.
NP_001311.3. NM_001320.6.
UniGeneiHs.73527.

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435.
ENST00000375866; ENSP00000365026; ENSG00000204435.
ENST00000375882; ENSP00000365042; ENSG00000204435.
ENST00000383427; ENSP00000372919; ENSG00000206406.
ENST00000383433; ENSP00000372925; ENSG00000206406.
ENST00000400110; ENSP00000382980; ENSG00000206406.
ENST00000412802; ENSP00000413469; ENSG00000224774.
ENST00000418230; ENSP00000411322; ENSG00000228875.
ENST00000422567; ENSP00000407018; ENSG00000224398.
ENST00000429633; ENSP00000409510; ENSG00000230700.
ENST00000431476; ENSP00000394855; ENSG00000224398.
ENST00000436169; ENSP00000412520; ENSG00000224398.
ENST00000443673; ENSP00000400188; ENSG00000230700.
ENST00000448596; ENSP00000391038; ENSG00000232960.
ENST00000451917; ENSP00000415303; ENSG00000224774.
ENST00000452985; ENSP00000415237; ENSG00000228875.
ENST00000453234; ENSP00000395275; ENSG00000224774.
ENST00000454382; ENSP00000390900; ENSG00000232960.
ENST00000454511; ENSP00000393756; ENSG00000232960.
ENST00000455161; ENSP00000407379; ENSG00000230700.
ENST00000458330; ENSP00000410802; ENSG00000228875.
GeneIDi1460.
KEGGihsa:1460.
UCSCiuc003nvr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA. Translation: CAA34811.1.
X16312 mRNA. Translation: CAA34379.1.
M30448 mRNA. Translation: AAA52123.1.
X57152 Genomic DNA. Translation: CAA40442.1.
AY113186 mRNA. Translation: AAM50092.1.
CR541699 mRNA. Translation: CAG46500.1.
AF129756 Genomic DNA. Translation: AAD18081.1.
BA000025 Genomic DNA. Translation: BAB63386.1.
DQ314868 Genomic DNA. Translation: ABC40727.1.
AK311860 mRNA. Translation: BAG34801.1.
AL662899 Genomic DNA. Translation: CAI96141.1.
AL662899 Genomic DNA. Translation: CAI18393.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17800.1.
AL805934 Genomic DNA. Translation: CAI18523.1.
BX511262 Genomic DNA. Translation: CAM45825.1.
CR753842 Genomic DNA. Translation: CAQ06572.1.
CR354443 Genomic DNA. Translation: CAQ07002.1.
CR759761 Genomic DNA. Translation: CAQ10879.1.
CH471081 Genomic DNA. Translation: EAX03473.1.
BC112017 mRNA. Translation: AAI12018.1.
BC112019 mRNA. Translation: AAI12020.1.
CCDSiCCDS4712.1.
PIRiA39459.
RefSeqiNP_001269314.1. NM_001282385.1.
NP_001311.3. NM_001320.6.
UniGeneiHs.73527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870.
SMRiP67870. Positions 7-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107843. 266 interactions.
DIPiDIP-131N.
IntActiP67870. 190 interactions.
MINTiMINT-88683.
STRINGi9606.ENSP00000365025.

Chemistry

ChEMBLiCHEMBL2095191.

PTM databases

iPTMnetiP67870.
PhosphoSiteiP67870.

Polymorphism and mutation databases

DMDMi54037520.

Proteomic databases

EPDiP67870.
MaxQBiP67870.
PaxDbiP67870.
PeptideAtlasiP67870.
PRIDEiP67870.

Protocols and materials databases

DNASUi1460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435.
ENST00000375866; ENSP00000365026; ENSG00000204435.
ENST00000375882; ENSP00000365042; ENSG00000204435.
ENST00000383427; ENSP00000372919; ENSG00000206406.
ENST00000383433; ENSP00000372925; ENSG00000206406.
ENST00000400110; ENSP00000382980; ENSG00000206406.
ENST00000412802; ENSP00000413469; ENSG00000224774.
ENST00000418230; ENSP00000411322; ENSG00000228875.
ENST00000422567; ENSP00000407018; ENSG00000224398.
ENST00000429633; ENSP00000409510; ENSG00000230700.
ENST00000431476; ENSP00000394855; ENSG00000224398.
ENST00000436169; ENSP00000412520; ENSG00000224398.
ENST00000443673; ENSP00000400188; ENSG00000230700.
ENST00000448596; ENSP00000391038; ENSG00000232960.
ENST00000451917; ENSP00000415303; ENSG00000224774.
ENST00000452985; ENSP00000415237; ENSG00000228875.
ENST00000453234; ENSP00000395275; ENSG00000224774.
ENST00000454382; ENSP00000390900; ENSG00000232960.
ENST00000454511; ENSP00000393756; ENSG00000232960.
ENST00000455161; ENSP00000407379; ENSG00000230700.
ENST00000458330; ENSP00000410802; ENSG00000228875.
GeneIDi1460.
KEGGihsa:1460.
UCSCiuc003nvr.3. human.

Organism-specific databases

CTDi1460.
GeneCardsiCSNK2B.
HGNCiHGNC:2460. CSNK2B.
HPAiCAB004349.
CAB013087.
CAB016059.
HPA005944.
MIMi115441. gene.
neXtProtiNX_P67870.
PharmGKBiPA26960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
HOVERGENiHBG051131.
InParanoidiP67870.
KOiK03115.
PhylomeDBiP67870.
TreeFamiTF314462.

Enzyme and pathway databases

ReactomeiR-HSA-201688. WNT mediated activation of DVL.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-445144. Signal transduction by L1.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiP67870.
SIGNORiP67870.

Miscellaneous databases

EvolutionaryTraceiP67870.
GeneWikiiCSNK2B.
GenomeRNAii1460.
PROiP67870.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204435.
CleanExiHS_CSNK2B.
ExpressionAtlasiP67870. baseline and differential.
GenevisibleiP67870. HS.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_HUMAN
AccessioniPrimary (citable) accession number: P67870
Secondary accession number(s): B0UXA9
, P07312, P13862, Q4VX47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.