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Protein

Snake venom vascular endothelial growth factor toxin VR-1

Gene
N/A
Organism
Daboia russelii (Russel's viper) (Vipera russelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces angiogenesis probably through VEGF receptor (KDR/VEGFR-2) signaling, as well as drastic hypotension. The hypotension is mediated by nitric oxide, which is produced by VEGF-activated endothelium NO synthase. May also induce capillary permeability.1 Publication

Keywords - Molecular functioni

Growth factor, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Snake venom vascular endothelial growth factor toxin VR-11 Publication
Short name:
svVEGF
Alternative name(s):
VEGF-FBy similarity
OrganismiDaboia russelii (Russel's viper) (Vipera russelii)
Taxonomic identifieri31159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeDaboia

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000016236225 – 133Snake venom vascular endothelial growth factor toxin VR-1Add BLAST109
PropeptideiPRO_0000406344134 – 144Add BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Pyrrolidone carboxylic acid1
Disulfide bondi38 ↔ 801 Publication
Disulfide bondi63Interchain (with C-48)1 Publication
Disulfide bondi69 ↔ 1151 Publication
Disulfide bondi72Interchain (with C-39)1 Publication
Disulfide bondi73 ↔ 1171 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with VEGF receptor-2 (KDR) with high affinity, but not with VEGF receptor-1 (Flt-1), VEGF receptor-3 (FLT4), and neuropilin-1 (NRP1).2 Publications

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 36Combined sources8
Beta strandi37 – 46Combined sources10
Helixi47 – 50Combined sources4
Beta strandi56 – 70Combined sources15
Beta strandi78 – 95Combined sources18
Turni97 – 99Combined sources3
Beta strandi102 – 119Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQ9X-ray2.00A/B26-119[»]
ProteinModelPortaliP67861.
SMRiP67861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67861.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000105.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYLLAVAI LFCIQGWPSG TVQGQVRPFL DVYERSACQT RETLVSILQE
60 70 80 90 100
HPDEISDIFR PSCVAVLRCS GCCTDESMKC TPVGKHTADI QIMRMNPRTH
110 120 130 140
SSKMEVMKFM EHTACECRPR WKQGEPEGPK EPRRGGVRAK FPFD
Length:144
Mass (Da):16,278
Last modified:April 5, 2011 - v2
Checksum:iE23F0BF70C47AD28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ554643 mRNA. Translation: ACN22046.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ554643 mRNA. Translation: ACN22046.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQ9X-ray2.00A/B26-119[»]
ProteinModelPortaliP67861.
SMRiP67861.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000105.

Miscellaneous databases

EvolutionaryTraceiP67861.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXVE_DABRR
AccessioniPrimary (citable) accession number: P67861
Secondary accession number(s): C0K3N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.