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Protein

Snake venom vascular endothelial growth factor toxin VR-1

Gene
N/A
Organism
Daboia russelii (Russel's viper) (Vipera russelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces angiogenesis probably through VEGF receptor (KDR/VEGFR-2) signaling, as well as drastic hypotension. The hypotension is mediated by nitric oxide, which is produced by VEGF-activated endothelium NO synthase. May also induce capillary permeability.1 Publication

Keywords - Molecular functioni

Growth factor, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Snake venom vascular endothelial growth factor toxin VR-11 Publication
Short name:
svVEGF
Alternative name(s):
VEGF-FBy similarity
OrganismiDaboia russelii (Russel's viper) (Vipera russelii)
Taxonomic identifieri31159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeDaboia

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 133109Snake venom vascular endothelial growth factor toxin VR-1PRO_0000162362Add
BLAST
Propeptidei134 – 14411PRO_0000406344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acid
Disulfide bondi38 ↔ 801 Publication
Disulfide bondi63 – 63Interchain (with C-48)1 Publication
Disulfide bondi69 ↔ 1151 Publication
Disulfide bondi72 – 72Interchain (with C-39)1 Publication
Disulfide bondi73 ↔ 1171 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with VEGF receptor-2 (KDR) with high affinity, but not with VEGF receptor-1 (Flt-1), VEGF receptor-3 (FLT4), and neuropilin-1 (NRP1).2 Publications

Structurei

Secondary structure

1
144
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 368Combined sources
Beta strandi37 – 4610Combined sources
Helixi47 – 504Combined sources
Beta strandi56 – 7015Combined sources
Beta strandi78 – 9518Combined sources
Turni97 – 993Combined sources
Beta strandi102 – 11918Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WQ9X-ray2.00A/B26-119[»]
ProteinModelPortaliP67861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67861.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000105.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYLLAVAI LFCIQGWPSG TVQGQVRPFL DVYERSACQT RETLVSILQE
60 70 80 90 100
HPDEISDIFR PSCVAVLRCS GCCTDESMKC TPVGKHTADI QIMRMNPRTH
110 120 130 140
SSKMEVMKFM EHTACECRPR WKQGEPEGPK EPRRGGVRAK FPFD
Length:144
Mass (Da):16,278
Last modified:April 5, 2011 - v2
Checksum:iE23F0BF70C47AD28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ554643 mRNA. Translation: ACN22046.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ554643 mRNA. Translation: ACN22046.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WQ9X-ray2.00A/B26-119[»]
ProteinModelPortaliP67861.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000105.

Miscellaneous databases

EvolutionaryTraceiP67861.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXVE_DABRR
AccessioniPrimary (citable) accession number: P67861
Secondary accession number(s): C0K3N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.