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P67828

- KC1A_RABIT

UniProt

P67828 - KC1A_RABIT

Protein

Casein kinase I isoform alpha

Gene

CSNK1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461ATPPROSITE-ProRule annotation
    Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 319ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein kinase activity Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell morphogenesis Source: Ensembl
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein phosphorylation Source: UniProtKB
    4. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform alpha (EC:2.7.11.1)
    Short name:
    CKI-alpha
    Alternative name(s):
    CK1
    Gene namesi
    Name:CSNK1A1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity
    Note: Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. nuclear speck Source: UniProtKB
    5. ribonucleoprotein complex Source: Ensembl

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 325324Casein kinase I isoform alphaPRO_0000192825Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei8 – 81N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YWHABP319463EBI-7540603,EBI-359815From a different organism.
    YwhaeP622602EBI-7540603,EBI-356462From a different organism.
    YWHAGP619813EBI-7540603,EBI-359832From a different organism.
    YWHAHQ049178EBI-7540603,EBI-306940From a different organism.
    YWHAQP273482EBI-7540603,EBI-359854From a different organism.
    YWHAZP631044EBI-7540603,EBI-347088From a different organism.

    Protein-protein interaction databases

    IntActiP67828. 9 interactions.
    MINTiMINT-7264083.

    Structurei

    3D structure databases

    ProteinModelPortaliP67828.
    SMRiP67828. Positions 17-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 285269Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110518.
    HOGENOMiHOG000182055.
    HOVERGENiHBG000176.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P67828-1 [UniParc]FASTAAdd to Basket

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    MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ    50
    KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL 100
    FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC 150
    NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR 200
    RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK 250
    GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM 300
    LKQKAAQQAA SSSGQGQQAQ TPTGF 325
    Length:325
    Mass (Da):37,567
    Last modified:October 11, 2004 - v1
    Checksum:iB84DC84BDDC17854
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59166 mRNA. Translation: AAB03992.1.
    RefSeqiNP_001075842.1. NM_001082373.1.
    UniGeneiOcu.2114.

    Genome annotation databases

    EnsembliENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669.
    GeneIDi100009227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59166 mRNA. Translation: AAB03992.1 .
    RefSeqi NP_001075842.1. NM_001082373.1.
    UniGenei Ocu.2114.

    3D structure databases

    ProteinModelPortali P67828.
    SMRi P67828. Positions 17-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P67828. 9 interactions.
    MINTi MINT-7264083.

    Chemistry

    BindingDBi P67828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000029447 ; ENSOCUP00000018081 ; ENSOCUG00000006669 .
    GeneIDi 100009227.

    Organism-specific databases

    CTDi 1452.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110518.
    HOGENOMi HOG000182055.
    HOVERGENi HBG000176.

    Miscellaneous databases

    NextBioi 20806353.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rabbit muscle casein kinase 1 alpha."
      Zhai L., DePaoli-Roach A.A., Roach P.J.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiKC1A_RABIT
    AccessioniPrimary (citable) accession number: P67828
    Secondary accession number(s): P35506
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3