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P67828

- KC1A_RABIT

UniProt

P67828 - KC1A_RABIT

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Protein
Casein kinase I isoform alpha
Gene
CSNK1A1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATP By similarity
Active sitei136 – 1361Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 319ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein kinase activity Source: UniProtKB
  4. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. cell morphogenesis Source: Ensembl
  3. mitotic nuclear division Source: UniProtKB-KW
  4. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform alpha (EC:2.7.11.1)
Short name:
CKI-alpha
Alternative name(s):
CK1
Gene namesi
Name:CSNK1A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 3

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity
Note: Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis By similarity.

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. microtubule organizing center Source: UniProtKB-SubCell
  4. nuclear speck Source: UniProtKB
  5. ribonucleoprotein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 325324Casein kinase I isoform alpha
PRO_0000192825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei8 – 81N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHABP319463EBI-7540603,EBI-359815From a different organism.
YwhaeP622602EBI-7540603,EBI-356462From a different organism.
YWHAGP619813EBI-7540603,EBI-359832From a different organism.
YWHAHQ049178EBI-7540603,EBI-306940From a different organism.
YWHAQP273482EBI-7540603,EBI-359854From a different organism.
YWHAZP631044EBI-7540603,EBI-347088From a different organism.

Protein-protein interaction databases

IntActiP67828. 9 interactions.
MINTiMINT-7264083.

Structurei

3D structure databases

ProteinModelPortaliP67828.
SMRiP67828. Positions 17-302.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 285269Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110518.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67828-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ    50
KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL 100
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC 150
NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR 200
RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK 250
GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM 300
LKQKAAQQAA SSSGQGQQAQ TPTGF 325
Length:325
Mass (Da):37,567
Last modified:October 11, 2004 - v1
Checksum:iB84DC84BDDC17854
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59166 mRNA. Translation: AAB03992.1.
RefSeqiNP_001075842.1. NM_001082373.1.
UniGeneiOcu.2114.

Genome annotation databases

EnsembliENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669.
GeneIDi100009227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59166 mRNA. Translation: AAB03992.1 .
RefSeqi NP_001075842.1. NM_001082373.1.
UniGenei Ocu.2114.

3D structure databases

ProteinModelPortali P67828.
SMRi P67828. Positions 17-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P67828. 9 interactions.
MINTi MINT-7264083.

Chemistry

BindingDBi P67828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000029447 ; ENSOCUP00000018081 ; ENSOCUG00000006669 .
GeneIDi 100009227.

Organism-specific databases

CTDi 1452.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110518.
HOGENOMi HOG000182055.
HOVERGENi HBG000176.

Miscellaneous databases

NextBioi 20806353.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rabbit muscle casein kinase 1 alpha."
    Zhai L., DePaoli-Roach A.A., Roach P.J.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiKC1A_RABIT
AccessioniPrimary (citable) accession number: P67828
Secondary accession number(s): P35506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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