ID   KC1A_RABIT              Reviewed;         325 AA.
AC   P67828; P35506;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-SEP-2014, entry version 75.
DE   RecName: Full=Casein kinase I isoform alpha;
DE            Short=CKI-alpha;
DE            EC=2.7.11.1;
DE   AltName: Full=CK1;
GN   Name=CSNK1A1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RA   Zhai L., DePaoli-Roach A.A., Roach P.J.;
RT   "Rabbit muscle casein kinase 1 alpha.";
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Casein kinases are operationally defined by their
CC       preferential utilization of acidic proteins such as caseins as
CC       substrates. It can phosphorylate a large number of proteins.
CC       Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'.
CC       May phosphorylate PER1 and PER2. May play a role in segregating
CC       chromosomes during mitosis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Monomer. Interacts with the Axin complex. Interacts with
CC       TUT1, leading to TUT1 phosphorylation (By similarity).
CC   -!- INTERACTION:
CC       P31946:YWHAB (xeno); NbExp=3; IntAct=EBI-7540603, EBI-359815;
CC       P62260:Ywhae (xeno); NbExp=2; IntAct=EBI-7540603, EBI-356462;
CC       P61981:YWHAG (xeno); NbExp=3; IntAct=EBI-7540603, EBI-359832;
CC       Q04917:YWHAH (xeno); NbExp=8; IntAct=EBI-7540603, EBI-306940;
CC       P27348:YWHAQ (xeno); NbExp=2; IntAct=EBI-7540603, EBI-359854;
CC       P63104:YWHAZ (xeno); NbExp=4; IntAct=EBI-7540603, EBI-347088;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome (By
CC       similarity). Chromosome, centromere, kinetochore (By similarity).
CC       Nucleus speckle (By similarity). Note=Localizes to the centrosome
CC       in interphase cells, and to kinetochore fibers during mitosis (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr
CC       protein kinase family. Casein kinase I subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; U59166; AAB03992.1; -; mRNA.
DR   RefSeq; NP_001075842.1; NM_001082373.1.
DR   UniGene; Ocu.2114; -.
DR   ProteinModelPortal; P67828; -.
DR   SMR; P67828; 17-302.
DR   IntAct; P67828; 9.
DR   MINT; MINT-7264083; -.
DR   BindingDB; P67828; -.
DR   Ensembl; ENSOCUT00000029447; ENSOCUP00000018081; ENSOCUG00000006669.
DR   GeneID; 100009227; -.
DR   CTD; 1452; -.
DR   eggNOG; COG0515; -.
DR   GeneTree; ENSGT00730000110518; -.
DR   HOGENOM; HOG000182055; -.
DR   HOVERGEN; HBG000176; -.
DR   NextBio; 20806353; -.
DR   GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0030529; C:ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR   GO; GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Cell cycle; Cell division; Centromere;
KW   Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase;
KW   Kinetochore; Mitosis; Nucleotide-binding; Nucleus; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    325       Casein kinase I isoform alpha.
FT                                /FTId=PRO_0000192825.
FT   DOMAIN       17    285       Protein kinase.
FT   NP_BIND      23     31       ATP (By similarity).
FT   ACT_SITE    136    136       Proton acceptor (By similarity).
FT   BINDING      46     46       ATP (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   MOD_RES       8      8       N6-acetyllysine (By similarity).
SQ   SEQUENCE   325 AA;  37567 MW;  B84DC84BDDC17854 CRC64;
     MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE
     SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM
     ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN
     LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK
     MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM
     LKQKAAQQAA SSSGQGQQAQ TPTGF
//